TRPing to the Point of Clarity: Understanding the Function of the Complex TRPV4 Ion Channel
Research output: Contribution to journal › Review › Research › peer-review
Standard
TRPing to the Point of Clarity : Understanding the Function of the Complex TRPV4 Ion Channel. / Toft-Bertelsen, Trine L.; MacAulay, Nanna.
In: Cells, Vol. 10, No. 1, 165, 2021.Research output: Contribution to journal › Review › Research › peer-review
Harvard
APA
Vancouver
Author
Bibtex
}
RIS
TY - JOUR
T1 - TRPing to the Point of Clarity
T2 - Understanding the Function of the Complex TRPV4 Ion Channel
AU - Toft-Bertelsen, Trine L.
AU - MacAulay, Nanna
PY - 2021
Y1 - 2021
N2 - The transient receptor potential vanilloid 4 channel (TRPV4) belongs to the mammalian TRP superfamily of cation channels. TRPV4 is ubiquitously expressed, activated by a disparate array of stimuli, interacts with a multitude of proteins, and is modulated by a range of post-translational modifications, the majority of which we are only just beginning to understand. Not surprisingly, a great number of physiological roles have emerged for TRPV4, as have various disease states that are attributable to the absence, or abnormal functioning, of this ion channel. This review will highlight structural features of TRPV4, endogenous and exogenous activators of the channel, and discuss the reported roles of TRPV4 in health and disease.
AB - The transient receptor potential vanilloid 4 channel (TRPV4) belongs to the mammalian TRP superfamily of cation channels. TRPV4 is ubiquitously expressed, activated by a disparate array of stimuli, interacts with a multitude of proteins, and is modulated by a range of post-translational modifications, the majority of which we are only just beginning to understand. Not surprisingly, a great number of physiological roles have emerged for TRPV4, as have various disease states that are attributable to the absence, or abnormal functioning, of this ion channel. This review will highlight structural features of TRPV4, endogenous and exogenous activators of the channel, and discuss the reported roles of TRPV4 in health and disease.
KW - TRP channels
KW - transient receptor potential vanilloid 4
KW - TRPV4
U2 - 10.3390/cells10010165
DO - 10.3390/cells10010165
M3 - Review
C2 - 33467654
VL - 10
JO - Cells
JF - Cells
SN - 2073-4409
IS - 1
M1 - 165
ER -
ID: 256314570