Transcranial alternating current stimulation of the primary motor cortex after skill acquisition improves motor memory retention in humans: A double-blinded sham-controlled study
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Transcranial alternating current stimulation of the primary motor cortex after skill acquisition improves motor memory retention in humans: A double-blinded sham-controlled study. / Yamaguchi, Tomofumi; Svane, Christian; Forman, Christian Riis; Beck, Mikkel Malling; Geertsen, Svend Sparre; Lundbye-Jensen, Jesper; Nielsen, Jens Bo.
In: Cerebral Cortex Communications, Vol. 1, No. 1, tgaa047, 2020.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Transcranial alternating current stimulation of the primary motor cortex after skill acquisition improves motor memory retention in humans: A double-blinded sham-controlled study
AU - Yamaguchi, Tomofumi
AU - Svane, Christian
AU - Forman, Christian Riis
AU - Beck, Mikkel Malling
AU - Geertsen, Svend Sparre
AU - Lundbye-Jensen, Jesper
AU - Nielsen, Jens Bo
N1 - © The Author(s) 2020. Published by Oxford University Press.
PY - 2020
Y1 - 2020
N2 - Consolidation leading to retention of motor memory following motor practice involves activity-dependent plastic processes in the corticospinal system. To investigate whether beta-band transcranial alternating current stimulation (tACS) applied immediately following skill acquisition can enhance ongoing consolidation processes and thereby motor skill retention 20 adults participated in a randomized, double-blinded, sham-controlled study. Participants received tACS at peak beta-band corticomuscular coherence (CMC) frequency or sham tACS for 10 min following practice of a visuomotor ankle dorsiflexion task. Performance was measured as the average percentage time on target. Electroencephalograhy (EMG) was measured at Cz and EMG from the right tibialis anterior muscle. CMC and intramuscular coherence (IMC) were estimated during 2-min tonic dorsiflexion. Motor skill retention was tested 1 and 7 days after motor practice. From the end of motor practice to the retention tests, motor performance improved more in the tACS group compared with the sham tACS group after 1 (P = 0.05) and 7 days (P < 0.001). At both retention tests, beta-band IMC increased in the tACS group compared with post-tACS. Beta-band CMC increased in the tACS group at retention day 1 compared with post-tACS. Changes in CMC but not IMC were correlated with performance 1 and 7 days following practice. This study shows that tACS applied at beta-band CMC frequency improves consolidation following visuomotor practice and increases beta-band CMC and IMC. We propose that oscillatory beta activity in the corticospinal system may facilitate consolidation of the motor skill.
AB - Consolidation leading to retention of motor memory following motor practice involves activity-dependent plastic processes in the corticospinal system. To investigate whether beta-band transcranial alternating current stimulation (tACS) applied immediately following skill acquisition can enhance ongoing consolidation processes and thereby motor skill retention 20 adults participated in a randomized, double-blinded, sham-controlled study. Participants received tACS at peak beta-band corticomuscular coherence (CMC) frequency or sham tACS for 10 min following practice of a visuomotor ankle dorsiflexion task. Performance was measured as the average percentage time on target. Electroencephalograhy (EMG) was measured at Cz and EMG from the right tibialis anterior muscle. CMC and intramuscular coherence (IMC) were estimated during 2-min tonic dorsiflexion. Motor skill retention was tested 1 and 7 days after motor practice. From the end of motor practice to the retention tests, motor performance improved more in the tACS group compared with the sham tACS group after 1 (P = 0.05) and 7 days (P < 0.001). At both retention tests, beta-band IMC increased in the tACS group compared with post-tACS. Beta-band CMC increased in the tACS group at retention day 1 compared with post-tACS. Changes in CMC but not IMC were correlated with performance 1 and 7 days following practice. This study shows that tACS applied at beta-band CMC frequency improves consolidation following visuomotor practice and increases beta-band CMC and IMC. We propose that oscillatory beta activity in the corticospinal system may facilitate consolidation of the motor skill.
KW - Faculty of Science
KW - Beta-band stimulation
KW - Corticomuscular coherence
KW - Intramuscular coherence
KW - Motor memory consolidation
KW - Transcranial alternating current stimulation
U2 - 10.1093/texcom/tgaa047
DO - 10.1093/texcom/tgaa047
M3 - Journal article
C2 - 34296115
VL - 1
JO - Cerebral Cortex Communications
JF - Cerebral Cortex Communications
SN - 2632-7376
IS - 1
M1 - tgaa047
ER -
ID: 275375019