Towards an electroencephalographic measure of awareness based on the reactivity of oscillatory macrostates to hearing a subject's own name
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Towards an electroencephalographic measure of awareness based on the reactivity of oscillatory macrostates to hearing a subject's own name. / Șerban, Cosmin Andrei; Barborică, Andrei; Roceanu, Adina Maria; Mîndruță, Ioana Raluca; Ciurea, Jan; Stancu, Mihai; Pâslaru, Alexandru C.; Zăgrean, Ana Maria; Zăgrean, Leon; Moldovan, Mihai.
In: European Journal of Neuroscience, Vol. 59, No. 5, 2024, p. 771-785.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Towards an electroencephalographic measure of awareness based on the reactivity of oscillatory macrostates to hearing a subject's own name
AU - Șerban, Cosmin Andrei
AU - Barborică, Andrei
AU - Roceanu, Adina Maria
AU - Mîndruță, Ioana Raluca
AU - Ciurea, Jan
AU - Stancu, Mihai
AU - Pâslaru, Alexandru C.
AU - Zăgrean, Ana Maria
AU - Zăgrean, Leon
AU - Moldovan, Mihai
N1 - Publisher Copyright: © 2023 Federation of European Neuroscience Societies and John Wiley & Sons Ltd.
PY - 2024
Y1 - 2024
N2 - We proposed that the brain's electrical activity is composed of a sequence of alternating states with repeating topographic spectral distributions on scalp electroencephalogram (EEG), referred to as oscillatory macrostates. The macrostate showing the largest decrease in the probability of occurrence, measured as a percentage (reactivity), during sensory stimulation was labelled as the default EEG macrostate (DEM). This study aimed to assess the influence of awareness on DEM reactivity (DER). We included 11 middle cerebral artery ischaemic stroke patients with impaired awareness having a median Glasgow Coma Scale (GCS) of 6/15 and a group of 11 matched healthy controls. EEG recordings were carried out during auditory 1 min stimulation epochs repeating either the subject's own name (SON) or the SON in reverse (rSON). The DEM was identified across three SON epochs alternating with three rSON epochs. Compared with the patients, the DEM of controls contained more posterior theta activity reflecting source dipoles that could be mapped in the posterior cingulate cortex. The DER was measured from the 1 min quiet baseline preceding each stimulation epoch. The difference in mean DER between the SON and rSON epochs was measured by the salient EEG reactivity (SER) theoretically ranging from −100% to 100%. The SER was 12.4 ± 2.7% (Mean ± standard error of the mean) in controls and only 1.3 ± 1.9% in the patient group (P < 0.01). The patient SER decreased with the Glasgow Coma Scale. Our data suggest that awareness increases DER to SON as measured by SER.
AB - We proposed that the brain's electrical activity is composed of a sequence of alternating states with repeating topographic spectral distributions on scalp electroencephalogram (EEG), referred to as oscillatory macrostates. The macrostate showing the largest decrease in the probability of occurrence, measured as a percentage (reactivity), during sensory stimulation was labelled as the default EEG macrostate (DEM). This study aimed to assess the influence of awareness on DEM reactivity (DER). We included 11 middle cerebral artery ischaemic stroke patients with impaired awareness having a median Glasgow Coma Scale (GCS) of 6/15 and a group of 11 matched healthy controls. EEG recordings were carried out during auditory 1 min stimulation epochs repeating either the subject's own name (SON) or the SON in reverse (rSON). The DEM was identified across three SON epochs alternating with three rSON epochs. Compared with the patients, the DEM of controls contained more posterior theta activity reflecting source dipoles that could be mapped in the posterior cingulate cortex. The DER was measured from the 1 min quiet baseline preceding each stimulation epoch. The difference in mean DER between the SON and rSON epochs was measured by the salient EEG reactivity (SER) theoretically ranging from −100% to 100%. The SER was 12.4 ± 2.7% (Mean ± standard error of the mean) in controls and only 1.3 ± 1.9% in the patient group (P < 0.01). The patient SER decreased with the Glasgow Coma Scale. Our data suggest that awareness increases DER to SON as measured by SER.
KW - (un)consciousness
KW - brain oscillations
KW - clinical neurophysiology
KW - coma
KW - stroke
U2 - 10.1111/ejn.16138
DO - 10.1111/ejn.16138
M3 - Journal article
C2 - 37675619
AN - SCOPUS:85169929987
VL - 59
SP - 771
EP - 785
JO - European Journal of Neuroscience
JF - European Journal of Neuroscience
SN - 0953-816X
IS - 5
ER -
ID: 366989452