The structure and function of endophilin proteins
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The structure and function of endophilin proteins. / Kjaerulff, Ole; Brodin, Lennart; Jung, Anita.
In: Cell Biochemistry and Biophysics, Vol. 60, No. 3, 01.07.2011, p. 137-54.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - The structure and function of endophilin proteins
AU - Kjaerulff, Ole
AU - Brodin, Lennart
AU - Jung, Anita
PY - 2011/7/1
Y1 - 2011/7/1
N2 - Members of the BAR domain protein superfamily are essential elements of cellular traffic. Endophilins are among the best studied BAR domain proteins. They have a prominent function in synaptic vesicle endocytosis (SVE), receptor trafficking and apoptosis, and in other processes that require remodeling of the membrane structure. Here, we discuss the role of endophilins in these processes and summarize novel insights into the molecular aspects of endophilin function. Also, we discuss phosphorylation of endophilins and how this and other mechanisms may contribute to disease.
AB - Members of the BAR domain protein superfamily are essential elements of cellular traffic. Endophilins are among the best studied BAR domain proteins. They have a prominent function in synaptic vesicle endocytosis (SVE), receptor trafficking and apoptosis, and in other processes that require remodeling of the membrane structure. Here, we discuss the role of endophilins in these processes and summarize novel insights into the molecular aspects of endophilin function. Also, we discuss phosphorylation of endophilins and how this and other mechanisms may contribute to disease.
U2 - 10.1007/s12013-010-9137-5
DO - 10.1007/s12013-010-9137-5
M3 - Journal article
C2 - 21184288
VL - 60
SP - 137
EP - 154
JO - Cell Biochemistry and Biophysics
JF - Cell Biochemistry and Biophysics
SN - 1085-9195
IS - 3
ER -
ID: 33793885