The perivascular phagocyte of the mouse pineal gland: An antigen-presenting cell
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The perivascular phagocyte of the mouse pineal gland: An antigen-presenting cell. / Møller, Morten; Rath, Martin F; Klein, David C.
In: Chronobiology International, Vol. 23, No. 1-2, 01.01.2006, p. 393-401.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - The perivascular phagocyte of the mouse pineal gland: An antigen-presenting cell
AU - Møller, Morten
AU - Rath, Martin F
AU - Klein, David C
PY - 2006/1/1
Y1 - 2006/1/1
N2 - The perivascular space of the rat pineal gland is known to contain phagocytic cells that are immunoreactive for leukocyte antigens, and thus they appear to belong to the macrophage/microglial cell line. These cells also contain MHC class II proteins. We investigated this cell type in the pineal gland of mice. Actively phagocytosing cells with a prominent lysosomal system were found in the pericapillary spaces of the mouse pineal gland following intravenous injection of horseradish peroxidase. The cells also exhibited strong acid phosphatase activity. Perivascular cells were immunopositive for MHC class II protein and for CD68, a marker of monocytes/phagocytes. This study verifies that perivascular phagocytes with antigen-presenting properties are present in the mouse pineal gland.
AB - The perivascular space of the rat pineal gland is known to contain phagocytic cells that are immunoreactive for leukocyte antigens, and thus they appear to belong to the macrophage/microglial cell line. These cells also contain MHC class II proteins. We investigated this cell type in the pineal gland of mice. Actively phagocytosing cells with a prominent lysosomal system were found in the pericapillary spaces of the mouse pineal gland following intravenous injection of horseradish peroxidase. The cells also exhibited strong acid phosphatase activity. Perivascular cells were immunopositive for MHC class II protein and for CD68, a marker of monocytes/phagocytes. This study verifies that perivascular phagocytes with antigen-presenting properties are present in the mouse pineal gland.
KW - Acid Phosphatase
KW - Animals
KW - Antigen-Presenting Cells
KW - Antigens, CD
KW - Antigens, Differentiation, Myelomonocytic
KW - Immunohistochemistry
KW - Mice
KW - Mice, Inbred BALB C
KW - Mice, Inbred C57BL
KW - Microscopy, Electron
KW - Microscopy, Electron, Transmission
KW - Monocytes
KW - Phagocytes
KW - Phagocytosis
KW - Pineal Gland
U2 - 10.1080/07420520500521855
DO - 10.1080/07420520500521855
M3 - Journal article
C2 - 16687312
VL - 23
SP - 393
EP - 401
JO - Chronobiology International
JF - Chronobiology International
SN - 0742-0528
IS - 1-2
ER -
ID: 1204390