The pathway for oxygen in brain

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The pathway for oxygen in brain. / Gjedde, Albert.

In: APMIS : Acta pathologica, microbiologica et immunologica Scandinavica. Supplementum, No. 109, 2003, p. 146-53.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Gjedde, A 2003, 'The pathway for oxygen in brain', APMIS : Acta pathologica, microbiologica et immunologica Scandinavica. Supplementum, no. 109, pp. 146-53.

APA

Gjedde, A. (2003). The pathway for oxygen in brain. APMIS : Acta pathologica, microbiologica et immunologica Scandinavica. Supplementum, (109), 146-53.

Vancouver

Gjedde A. The pathway for oxygen in brain. APMIS : Acta pathologica, microbiologica et immunologica Scandinavica. Supplementum. 2003;(109):146-53.

Author

Gjedde, Albert. / The pathway for oxygen in brain. In: APMIS : Acta pathologica, microbiologica et immunologica Scandinavica. Supplementum. 2003 ; No. 109. pp. 146-53.

Bibtex

@article{3f8528b0b31511debc73000ea68e967b,
title = "The pathway for oxygen in brain",
abstract = "Blood-brain transfer of oxygen is a fundamental function of regional oxygen consumption. This function yielded a novel description of the mechanism of flow-metabolism coupling. The description revealed that constant oxygen consumption is not maintained by saturation of cytochrome oxidase but by adjustment of the enzyme's affinity towards oxygen. Interactions of oxygen and a factor that could be nitric oxide, at both cytochrome oxidase and nitric oxide synthase, match the affinities of both enzymes towards their respective substrates to the oxygen requirement of the tissue and, in doing so, explain several properties of flow-metabolism coupling.",
author = "Albert Gjedde",
year = "2003",
language = "English",
pages = "146--53",
journal = "APMIS. Supplementum",
issn = "0903-465X",
publisher = "Wiley-Blackwell",
number = "109",

}

RIS

TY - JOUR

T1 - The pathway for oxygen in brain

AU - Gjedde, Albert

PY - 2003

Y1 - 2003

N2 - Blood-brain transfer of oxygen is a fundamental function of regional oxygen consumption. This function yielded a novel description of the mechanism of flow-metabolism coupling. The description revealed that constant oxygen consumption is not maintained by saturation of cytochrome oxidase but by adjustment of the enzyme's affinity towards oxygen. Interactions of oxygen and a factor that could be nitric oxide, at both cytochrome oxidase and nitric oxide synthase, match the affinities of both enzymes towards their respective substrates to the oxygen requirement of the tissue and, in doing so, explain several properties of flow-metabolism coupling.

AB - Blood-brain transfer of oxygen is a fundamental function of regional oxygen consumption. This function yielded a novel description of the mechanism of flow-metabolism coupling. The description revealed that constant oxygen consumption is not maintained by saturation of cytochrome oxidase but by adjustment of the enzyme's affinity towards oxygen. Interactions of oxygen and a factor that could be nitric oxide, at both cytochrome oxidase and nitric oxide synthase, match the affinities of both enzymes towards their respective substrates to the oxygen requirement of the tissue and, in doing so, explain several properties of flow-metabolism coupling.

M3 - Journal article

C2 - 12874967

SP - 146

EP - 153

JO - APMIS. Supplementum

JF - APMIS. Supplementum

SN - 0903-465X

IS - 109

ER -

ID: 14946647