The local field potential reflects surplus spike synchrony
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The local field potential reflects surplus spike synchrony. / Denker, Michael; Roux, Sébastien; Lindén, Henrik; Diesmann, Markus; Riehle, Alexa; Grün, Sonja.
In: Cerebral cortex (New York, N.Y. : 1991), Vol. 21, No. 12, 12.2011, p. 2681-95.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - The local field potential reflects surplus spike synchrony
AU - Denker, Michael
AU - Roux, Sébastien
AU - Lindén, Henrik
AU - Diesmann, Markus
AU - Riehle, Alexa
AU - Grün, Sonja
PY - 2011/12
Y1 - 2011/12
N2 - While oscillations of the local field potential (LFP) are commonly attributed to the synchronization of neuronal firing rate on the same time scale, their relationship to coincident spiking in the millisecond range is unknown. Here, we present experimental evidence to reconcile the notions of synchrony at the level of spiking and at the mesoscopic scale. We demonstrate that only in time intervals of significant spike synchrony that cannot be explained on the basis of firing rates, coincident spikes are better phase locked to the LFP than predicted by the locking of the individual spikes. This effect is enhanced in periods of large LFP amplitudes. A quantitative model explains the LFP dynamics by the orchestrated spiking activity in neuronal groups that contribute the observed surplus synchrony. From the correlation analysis, we infer that neurons participate in different constellations but contribute only a fraction of their spikes to temporally precise spike configurations. This finding provides direct evidence for the hypothesized relation that precise spike synchrony constitutes a major temporally and spatially organized component of the LFP.
AB - While oscillations of the local field potential (LFP) are commonly attributed to the synchronization of neuronal firing rate on the same time scale, their relationship to coincident spiking in the millisecond range is unknown. Here, we present experimental evidence to reconcile the notions of synchrony at the level of spiking and at the mesoscopic scale. We demonstrate that only in time intervals of significant spike synchrony that cannot be explained on the basis of firing rates, coincident spikes are better phase locked to the LFP than predicted by the locking of the individual spikes. This effect is enhanced in periods of large LFP amplitudes. A quantitative model explains the LFP dynamics by the orchestrated spiking activity in neuronal groups that contribute the observed surplus synchrony. From the correlation analysis, we infer that neurons participate in different constellations but contribute only a fraction of their spikes to temporally precise spike configurations. This finding provides direct evidence for the hypothesized relation that precise spike synchrony constitutes a major temporally and spatially organized component of the LFP.
KW - Action Potentials
KW - Animals
KW - Cortical Synchronization
KW - Electrophysiology
KW - Macaca mulatta
KW - Motor Cortex
KW - Neurons
KW - Signal Processing, Computer-Assisted
U2 - 10.1093/cercor/bhr040
DO - 10.1093/cercor/bhr040
M3 - Journal article
C2 - 21508303
VL - 21
SP - 2681
EP - 2695
JO - Cerebral Cortex
JF - Cerebral Cortex
SN - 1566-6816
IS - 12
ER -
ID: 50204759