The CNTF-derived peptide mimetic Cintrofin attenuates spatial-learning deficits in a rat post-status epilepticus model

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Standard

The CNTF-derived peptide mimetic Cintrofin attenuates spatial-learning deficits in a rat post-status epilepticus model. / Russmann, Vera; Seeger, Natalie; Zellinger, Christina; Hadamitzky, Martin; Pankratova, Stanislava; Wendt, Hannes; Bock, Elisabeth; Berezin, Vladimir; Potschka, Heidrun.

In: Neuroscience Letters, Vol. 556, 27.11.2013, p. 170-5.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Russmann, V, Seeger, N, Zellinger, C, Hadamitzky, M, Pankratova, S, Wendt, H, Bock, E, Berezin, V & Potschka, H 2013, 'The CNTF-derived peptide mimetic Cintrofin attenuates spatial-learning deficits in a rat post-status epilepticus model', Neuroscience Letters, vol. 556, pp. 170-5. https://doi.org/10.1016/j.neulet.2013.10.003

APA

Russmann, V., Seeger, N., Zellinger, C., Hadamitzky, M., Pankratova, S., Wendt, H., Bock, E., Berezin, V., & Potschka, H. (2013). The CNTF-derived peptide mimetic Cintrofin attenuates spatial-learning deficits in a rat post-status epilepticus model. Neuroscience Letters, 556, 170-5. https://doi.org/10.1016/j.neulet.2013.10.003

Vancouver

Russmann V, Seeger N, Zellinger C, Hadamitzky M, Pankratova S, Wendt H et al. The CNTF-derived peptide mimetic Cintrofin attenuates spatial-learning deficits in a rat post-status epilepticus model. Neuroscience Letters. 2013 Nov 27;556:170-5. https://doi.org/10.1016/j.neulet.2013.10.003

Author

Russmann, Vera ; Seeger, Natalie ; Zellinger, Christina ; Hadamitzky, Martin ; Pankratova, Stanislava ; Wendt, Hannes ; Bock, Elisabeth ; Berezin, Vladimir ; Potschka, Heidrun. / The CNTF-derived peptide mimetic Cintrofin attenuates spatial-learning deficits in a rat post-status epilepticus model. In: Neuroscience Letters. 2013 ; Vol. 556. pp. 170-5.

Bibtex

@article{84423924568e4590ac20f08a28c5ba75,
title = "The CNTF-derived peptide mimetic Cintrofin attenuates spatial-learning deficits in a rat post-status epilepticus model",
abstract = "Ciliary neurotrophic growth factor is considered a potential therapeutic agent for central nervous system diseases. We report first in vivo data of the ciliary neurotrophic growth factor peptide mimetic Cintrofin in a rat post-status epilepticus model. Cintrofin prevented long-term alterations in the number of doublecortin-positive neuronal progenitor cells and attenuated the persistence of basal dendrites. In contrast, Cintrofin did neither affect acute status epilepticus-associated alterations in hippocampal cell proliferation and neurogenesis nor reveal any relevant effect on seizure activity. Whereas status epilepticus caused a significant disturbance in spatial learning in reversed peptide-treated rats, the performance of Cintrofin-treated rats did not differ from controls. The study confirms that Cintrofin comprises an active sequence mimicking effects of its parent molecule. While the data argue against an antiepileptogenic effect, they indicate a putative disease-modifying impact of Cintrofin.",
keywords = "Animals, Ciliary Neurotrophic Factor, Female, Hippocampus, Learning, Microglia, Molecular Mimicry, Nerve Degeneration, Neurogenesis, Neurons, Peptide Fragments, Rats, Rats, Sprague-Dawley, Status Epilepticus",
author = "Vera Russmann and Natalie Seeger and Christina Zellinger and Martin Hadamitzky and Stanislava Pankratova and Hannes Wendt and Elisabeth Bock and Vladimir Berezin and Heidrun Potschka",
note = "Copyright {\textcopyright} 2013 Elsevier Ireland Ltd. All rights reserved.",
year = "2013",
month = nov,
day = "27",
doi = "10.1016/j.neulet.2013.10.003",
language = "English",
volume = "556",
pages = "170--5",
journal = "Neuroscience letters. Supplement",
issn = "0167-6253",
publisher = "Elsevier Ireland Ltd",

}

RIS

TY - JOUR

T1 - The CNTF-derived peptide mimetic Cintrofin attenuates spatial-learning deficits in a rat post-status epilepticus model

AU - Russmann, Vera

AU - Seeger, Natalie

AU - Zellinger, Christina

AU - Hadamitzky, Martin

AU - Pankratova, Stanislava

AU - Wendt, Hannes

AU - Bock, Elisabeth

AU - Berezin, Vladimir

AU - Potschka, Heidrun

N1 - Copyright © 2013 Elsevier Ireland Ltd. All rights reserved.

PY - 2013/11/27

Y1 - 2013/11/27

N2 - Ciliary neurotrophic growth factor is considered a potential therapeutic agent for central nervous system diseases. We report first in vivo data of the ciliary neurotrophic growth factor peptide mimetic Cintrofin in a rat post-status epilepticus model. Cintrofin prevented long-term alterations in the number of doublecortin-positive neuronal progenitor cells and attenuated the persistence of basal dendrites. In contrast, Cintrofin did neither affect acute status epilepticus-associated alterations in hippocampal cell proliferation and neurogenesis nor reveal any relevant effect on seizure activity. Whereas status epilepticus caused a significant disturbance in spatial learning in reversed peptide-treated rats, the performance of Cintrofin-treated rats did not differ from controls. The study confirms that Cintrofin comprises an active sequence mimicking effects of its parent molecule. While the data argue against an antiepileptogenic effect, they indicate a putative disease-modifying impact of Cintrofin.

AB - Ciliary neurotrophic growth factor is considered a potential therapeutic agent for central nervous system diseases. We report first in vivo data of the ciliary neurotrophic growth factor peptide mimetic Cintrofin in a rat post-status epilepticus model. Cintrofin prevented long-term alterations in the number of doublecortin-positive neuronal progenitor cells and attenuated the persistence of basal dendrites. In contrast, Cintrofin did neither affect acute status epilepticus-associated alterations in hippocampal cell proliferation and neurogenesis nor reveal any relevant effect on seizure activity. Whereas status epilepticus caused a significant disturbance in spatial learning in reversed peptide-treated rats, the performance of Cintrofin-treated rats did not differ from controls. The study confirms that Cintrofin comprises an active sequence mimicking effects of its parent molecule. While the data argue against an antiepileptogenic effect, they indicate a putative disease-modifying impact of Cintrofin.

KW - Animals

KW - Ciliary Neurotrophic Factor

KW - Female

KW - Hippocampus

KW - Learning

KW - Microglia

KW - Molecular Mimicry

KW - Nerve Degeneration

KW - Neurogenesis

KW - Neurons

KW - Peptide Fragments

KW - Rats

KW - Rats, Sprague-Dawley

KW - Status Epilepticus

U2 - 10.1016/j.neulet.2013.10.003

DO - 10.1016/j.neulet.2013.10.003

M3 - Journal article

C2 - 24120433

VL - 556

SP - 170

EP - 175

JO - Neuroscience letters. Supplement

JF - Neuroscience letters. Supplement

SN - 0167-6253

ER -

ID: 118388488