The alpha7 nicotinic receptor agonist SSR180711 increases activity regulated cytoskeleton protein (Arc) gene expression in the prefrontal cortex of the rat
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The alpha7 nicotinic receptor agonist SSR180711 increases activity regulated cytoskeleton protein (Arc) gene expression in the prefrontal cortex of the rat. / Kristensen, Søren; Thomsen, Morten Skøtt; Hansen, Henrik H; Timmermann, Daniel B; Hay-Schmidt, Anders; Mikkelsen, Jens D.
In: Neuroscience Letters, Vol. 418, No. 2, 17.05.2007, p. 154-8.Research output: Contribution to journal › Journal article › Research
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T1 - The alpha7 nicotinic receptor agonist SSR180711 increases activity regulated cytoskeleton protein (Arc) gene expression in the prefrontal cortex of the rat
AU - Kristensen, Søren
AU - Thomsen, Morten Skøtt
AU - Hansen, Henrik H
AU - Timmermann, Daniel B
AU - Hay-Schmidt, Anders
AU - Mikkelsen, Jens D
PY - 2007/5/17
Y1 - 2007/5/17
N2 - Nicotinic alpha7 acetylcholine receptors (alpha7 nAChR) have been shown to enhance attentional function and aspects of memory function in experimental models and in man. The protein Arc encoded by the effector immediate early gene arc or arg3.1 has been shown to be strongly implicated in long-term memory function. We have sought to determine if alpha7 nAChR mediate the stimulation of arc gene expression, and if so, where in the brain such activation may occur using semi-quantitative in situ hybridisation. Administration of the novel and selective alpha7 nAChR agonist, SSR180711 (1, 3 and 10 mg/kg) to adolescent rats, produced a dose- and time-dependent increase in the expression of Arc mRNA in the prefrontal cortex and the ventral orbital cortex. By contrast, no change in mRNA levels was detected in the parietal cortex and the CA1 of the hippocampus. These data show that alpha7 nAChR activates a subset of neurons in the rat prefrontal cortex and this activation likely is important for the attentional effects of this new class of drugs.
AB - Nicotinic alpha7 acetylcholine receptors (alpha7 nAChR) have been shown to enhance attentional function and aspects of memory function in experimental models and in man. The protein Arc encoded by the effector immediate early gene arc or arg3.1 has been shown to be strongly implicated in long-term memory function. We have sought to determine if alpha7 nAChR mediate the stimulation of arc gene expression, and if so, where in the brain such activation may occur using semi-quantitative in situ hybridisation. Administration of the novel and selective alpha7 nAChR agonist, SSR180711 (1, 3 and 10 mg/kg) to adolescent rats, produced a dose- and time-dependent increase in the expression of Arc mRNA in the prefrontal cortex and the ventral orbital cortex. By contrast, no change in mRNA levels was detected in the parietal cortex and the CA1 of the hippocampus. These data show that alpha7 nAChR activates a subset of neurons in the rat prefrontal cortex and this activation likely is important for the attentional effects of this new class of drugs.
KW - Acetylcholine
KW - Animals
KW - Attention
KW - Attention Deficit Disorder with Hyperactivity
KW - Bicyclo Compounds, Heterocyclic
KW - Cytoskeletal Proteins
KW - Dose-Response Relationship, Drug
KW - Gene Expression Regulation
KW - In Situ Hybridization
KW - Male
KW - Memory
KW - Memory Disorders
KW - Nerve Tissue Proteins
KW - Nicotinic Agonists
KW - Prefrontal Cortex
KW - RNA, Messenger
KW - Rats
KW - Rats, Wistar
KW - Receptors, Nicotinic
KW - Synaptic Transmission
KW - Time Factors
KW - Up-Regulation
KW - alpha7 Nicotinic Acetylcholine Receptor
U2 - 10.1016/j.neulet.2007.03.016
DO - 10.1016/j.neulet.2007.03.016
M3 - Journal article
C2 - 17379406
VL - 418
SP - 154
EP - 158
JO - Neuroscience letters. Supplement
JF - Neuroscience letters. Supplement
SN - 0167-6253
IS - 2
ER -
ID: 111182816