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SynGO : An Evidence-Based, Expert-Curated Knowledge Base for the Synapse. / Koopmans, Frank; van Nierop, Pim; Andres-Alonso, Maria; Byrnes, Andrea; Cijsouw, Tony; Coba, Marcelo P; Cornelisse, L Niels; Farrell, Ryan J; Goldschmidt, Hana L; Howrigan, Daniel P; Hussain, Natasha K; Imig, Cordelia; de Jong, Arthur P H; Jung, Hwajin; Kohansalnodehi, Mahdokht; Kramarz, Barbara; Lipstein, Noa; Lovering, Ruth C; MacGillavry, Harold; Mariano, Vittoria; Mi, Huaiyu; Ninov, Momchil; Osumi-Sutherland, David; Pielot, Rainer; Smalla, Karl-Heinz; Tang, Haiming; Tashman, Katherine; Toonen, Ruud F G; Verpelli, Chiara; Reig-Viader, Rita; Watanabe, Kyoko; van Weering, Jan; Achsel, Tilmann; Ashrafi, Ghazaleh; Asi, Nimra; Brown, Tyler C; De Camilli, Pietro; Feuermann, Marc; Foulger, Rebecca E; Gaudet, Pascale; Joglekar, Anoushka; Kanellopoulos, Alexandros; Malenka, Robert; Nicoll, Roger A; Pulido, Camila; de Juan-Sanz, Jaime; Sheng, Morgan; Südhof, Thomas C; Tilgner, Hagen U; Bagni, Claudia; Bayés, Àlex; Biederer, Thomas; Brose, Nils; Chua, John Jia En; Dieterich, Daniela C; Gundelfinger, Eckart D; Hoogenraad, Casper; Huganir, Richard L; Jahn, Reinhard; Kaeser, Pascal S; Kim, Eunjoon; Kreutz, Michael R; McPherson, Peter S; Neale, Ben M; O'Connor, Vincent; Posthuma, Danielle; Ryan, Timothy A; Sala, Carlo; Feng, Guoping; Hyman, Steven E; Thomas, Paul D; Smit, August B; Verhage, Matthijs.
In:
Neuron, Vol. 103, No. 2, 17.07.2019, p. 217-234.e4.
Research output: Contribution to journal › Journal article › Research › peer-review
Harvard
Koopmans, F, van Nierop, P, Andres-Alonso, M, Byrnes, A, Cijsouw, T, Coba, MP, Cornelisse, LN, Farrell, RJ, Goldschmidt, HL, Howrigan, DP, Hussain, NK
, Imig, C, de Jong, APH, Jung, H, Kohansalnodehi, M, Kramarz, B, Lipstein, N, Lovering, RC, MacGillavry, H, Mariano, V, Mi, H, Ninov, M, Osumi-Sutherland, D, Pielot, R, Smalla, K-H, Tang, H, Tashman, K, Toonen, RFG, Verpelli, C, Reig-Viader, R, Watanabe, K, van Weering, J, Achsel, T, Ashrafi, G, Asi, N, Brown, TC, De Camilli, P, Feuermann, M, Foulger, RE, Gaudet, P, Joglekar, A, Kanellopoulos, A, Malenka, R, Nicoll, RA, Pulido, C, de Juan-Sanz, J, Sheng, M, Südhof, TC, Tilgner, HU, Bagni, C, Bayés, À, Biederer, T, Brose, N, Chua, JJE, Dieterich, DC, Gundelfinger, ED, Hoogenraad, C, Huganir, RL, Jahn, R, Kaeser, PS, Kim, E, Kreutz, MR, McPherson, PS, Neale, BM, O'Connor, V, Posthuma, D, Ryan, TA, Sala, C, Feng, G, Hyman, SE, Thomas, PD, Smit, AB & Verhage, M 2019, '
SynGO: An Evidence-Based, Expert-Curated Knowledge Base for the Synapse',
Neuron, vol. 103, no. 2, pp. 217-234.e4.
https://doi.org/10.1016/j.neuron.2019.05.002APA
Koopmans, F., van Nierop, P., Andres-Alonso, M., Byrnes, A., Cijsouw, T., Coba, M. P., Cornelisse, L. N., Farrell, R. J., Goldschmidt, H. L., Howrigan, D. P., Hussain, N. K.
, Imig, C., de Jong, A. P. H., Jung, H., Kohansalnodehi, M., Kramarz, B., Lipstein, N., Lovering, R. C., MacGillavry, H., ... Verhage, M. (2019).
SynGO: An Evidence-Based, Expert-Curated Knowledge Base for the Synapse.
Neuron,
103(2), 217-234.e4.
https://doi.org/10.1016/j.neuron.2019.05.002Vancouver
Koopmans F, van Nierop P, Andres-Alonso M, Byrnes A, Cijsouw T, Coba MP et al.
SynGO: An Evidence-Based, Expert-Curated Knowledge Base for the Synapse.
Neuron. 2019 Jul 17;103(2):217-234.e4.
https://doi.org/10.1016/j.neuron.2019.05.002Author
Koopmans, Frank ; van Nierop, Pim ; Andres-Alonso, Maria ; Byrnes, Andrea ; Cijsouw, Tony ; Coba, Marcelo P ; Cornelisse, L Niels ; Farrell, Ryan J ; Goldschmidt, Hana L ; Howrigan, Daniel P ; Hussain, Natasha K ; Imig, Cordelia ; de Jong, Arthur P H ; Jung, Hwajin ; Kohansalnodehi, Mahdokht ; Kramarz, Barbara ; Lipstein, Noa ; Lovering, Ruth C ; MacGillavry, Harold ; Mariano, Vittoria ; Mi, Huaiyu ; Ninov, Momchil ; Osumi-Sutherland, David ; Pielot, Rainer ; Smalla, Karl-Heinz ; Tang, Haiming ; Tashman, Katherine ; Toonen, Ruud F G ; Verpelli, Chiara ; Reig-Viader, Rita ; Watanabe, Kyoko ; van Weering, Jan ; Achsel, Tilmann ; Ashrafi, Ghazaleh ; Asi, Nimra ; Brown, Tyler C ; De Camilli, Pietro ; Feuermann, Marc ; Foulger, Rebecca E ; Gaudet, Pascale ; Joglekar, Anoushka ; Kanellopoulos, Alexandros ; Malenka, Robert ; Nicoll, Roger A ; Pulido, Camila ; de Juan-Sanz, Jaime ; Sheng, Morgan ; Südhof, Thomas C ; Tilgner, Hagen U ; Bagni, Claudia ; Bayés, Àlex ; Biederer, Thomas ; Brose, Nils ; Chua, John Jia En ; Dieterich, Daniela C ; Gundelfinger, Eckart D ; Hoogenraad, Casper ; Huganir, Richard L ; Jahn, Reinhard ; Kaeser, Pascal S ; Kim, Eunjoon ; Kreutz, Michael R ; McPherson, Peter S ; Neale, Ben M ; O'Connor, Vincent ; Posthuma, Danielle ; Ryan, Timothy A ; Sala, Carlo ; Feng, Guoping ; Hyman, Steven E ; Thomas, Paul D ; Smit, August B ; Verhage, Matthijs. / SynGO : An Evidence-Based, Expert-Curated Knowledge Base for the Synapse. In: Neuron. 2019 ; Vol. 103, No. 2. pp. 217-234.e4.
Bibtex
@article{cdeb39b5b9b340b1a89790e65e1bf22c,
title = "SynGO: An Evidence-Based, Expert-Curated Knowledge Base for the Synapse",
abstract = "Synapses are fundamental information-processing units of the brain, and synaptic dysregulation is central to many brain disorders ({"}synaptopathies{"}). However, systematic annotation of synaptic genes and ontology of synaptic processes are currently lacking. We established SynGO, an interactive knowledge base that accumulates available research about synapse biology using Gene Ontology (GO) annotations to novel ontology terms: 87 synaptic locations and 179 synaptic processes. SynGO annotations are exclusively based on published, expert-curated evidence. Using 2,922 annotations for 1,112 genes, we show that synaptic genes are exceptionally well conserved and less tolerant to mutations than other genes. Many SynGO terms are significantly overrepresented among gene variations associated with intelligence, educational attainment, ADHD, autism, and bipolar disorder and among de novo variants associated with neurodevelopmental disorders, including schizophrenia. SynGO is a public, universal reference for synapse research and an online analysis platform for interpretation of large-scale -omics data (https://syngoportal.org and http://geneontology.org).",
keywords = "Animals, Brain/cytology, Databases, Genetic, Gene Ontology, Humans, Knowledge Bases, Proteomics, Software, Synapses/physiology, Synaptic Potentials/physiology, Synaptosomes",
author = "Frank Koopmans and {van Nierop}, Pim and Maria Andres-Alonso and Andrea Byrnes and Tony Cijsouw and Coba, {Marcelo P} and Cornelisse, {L Niels} and Farrell, {Ryan J} and Goldschmidt, {Hana L} and Howrigan, {Daniel P} and Hussain, {Natasha K} and Cordelia Imig and {de Jong}, {Arthur P H} and Hwajin Jung and Mahdokht Kohansalnodehi and Barbara Kramarz and Noa Lipstein and Lovering, {Ruth C} and Harold MacGillavry and Vittoria Mariano and Huaiyu Mi and Momchil Ninov and David Osumi-Sutherland and Rainer Pielot and Karl-Heinz Smalla and Haiming Tang and Katherine Tashman and Toonen, {Ruud F G} and Chiara Verpelli and Rita Reig-Viader and Kyoko Watanabe and {van Weering}, Jan and Tilmann Achsel and Ghazaleh Ashrafi and Nimra Asi and Brown, {Tyler C} and {De Camilli}, Pietro and Marc Feuermann and Foulger, {Rebecca E} and Pascale Gaudet and Anoushka Joglekar and Alexandros Kanellopoulos and Robert Malenka and Nicoll, {Roger A} and Camila Pulido and {de Juan-Sanz}, Jaime and Morgan Sheng and S{\"u}dhof, {Thomas C} and Tilgner, {Hagen U} and Claudia Bagni and {\`A}lex Bay{\'e}s and Thomas Biederer and Nils Brose and Chua, {John Jia En} and Dieterich, {Daniela C} and Gundelfinger, {Eckart D} and Casper Hoogenraad and Huganir, {Richard L} and Reinhard Jahn and Kaeser, {Pascal S} and Eunjoon Kim and Kreutz, {Michael R} and McPherson, {Peter S} and Neale, {Ben M} and Vincent O'Connor and Danielle Posthuma and Ryan, {Timothy A} and Carlo Sala and Guoping Feng and Hyman, {Steven E} and Thomas, {Paul D} and Smit, {August B} and Matthijs Verhage",
note = "Copyright {\textcopyright} 2019 Elsevier Inc. All rights reserved.",
year = "2019",
month = jul,
day = "17",
doi = "10.1016/j.neuron.2019.05.002",
language = "English",
volume = "103",
pages = "217--234.e4",
journal = "Neuron",
issn = "0896-6273",
publisher = "Cell Press",
number = "2",
}
RIS
TY - JOUR
T1 - SynGO
T2 - An Evidence-Based, Expert-Curated Knowledge Base for the Synapse
AU - Koopmans, Frank
AU - van Nierop, Pim
AU - Andres-Alonso, Maria
AU - Byrnes, Andrea
AU - Cijsouw, Tony
AU - Coba, Marcelo P
AU - Cornelisse, L Niels
AU - Farrell, Ryan J
AU - Goldschmidt, Hana L
AU - Howrigan, Daniel P
AU - Hussain, Natasha K
AU - Imig, Cordelia
AU - de Jong, Arthur P H
AU - Jung, Hwajin
AU - Kohansalnodehi, Mahdokht
AU - Kramarz, Barbara
AU - Lipstein, Noa
AU - Lovering, Ruth C
AU - MacGillavry, Harold
AU - Mariano, Vittoria
AU - Mi, Huaiyu
AU - Ninov, Momchil
AU - Osumi-Sutherland, David
AU - Pielot, Rainer
AU - Smalla, Karl-Heinz
AU - Tang, Haiming
AU - Tashman, Katherine
AU - Toonen, Ruud F G
AU - Verpelli, Chiara
AU - Reig-Viader, Rita
AU - Watanabe, Kyoko
AU - van Weering, Jan
AU - Achsel, Tilmann
AU - Ashrafi, Ghazaleh
AU - Asi, Nimra
AU - Brown, Tyler C
AU - De Camilli, Pietro
AU - Feuermann, Marc
AU - Foulger, Rebecca E
AU - Gaudet, Pascale
AU - Joglekar, Anoushka
AU - Kanellopoulos, Alexandros
AU - Malenka, Robert
AU - Nicoll, Roger A
AU - Pulido, Camila
AU - de Juan-Sanz, Jaime
AU - Sheng, Morgan
AU - Südhof, Thomas C
AU - Tilgner, Hagen U
AU - Bagni, Claudia
AU - Bayés, Àlex
AU - Biederer, Thomas
AU - Brose, Nils
AU - Chua, John Jia En
AU - Dieterich, Daniela C
AU - Gundelfinger, Eckart D
AU - Hoogenraad, Casper
AU - Huganir, Richard L
AU - Jahn, Reinhard
AU - Kaeser, Pascal S
AU - Kim, Eunjoon
AU - Kreutz, Michael R
AU - McPherson, Peter S
AU - Neale, Ben M
AU - O'Connor, Vincent
AU - Posthuma, Danielle
AU - Ryan, Timothy A
AU - Sala, Carlo
AU - Feng, Guoping
AU - Hyman, Steven E
AU - Thomas, Paul D
AU - Smit, August B
AU - Verhage, Matthijs
N1 - Copyright © 2019 Elsevier Inc. All rights reserved.
PY - 2019/7/17
Y1 - 2019/7/17
N2 - Synapses are fundamental information-processing units of the brain, and synaptic dysregulation is central to many brain disorders ("synaptopathies"). However, systematic annotation of synaptic genes and ontology of synaptic processes are currently lacking. We established SynGO, an interactive knowledge base that accumulates available research about synapse biology using Gene Ontology (GO) annotations to novel ontology terms: 87 synaptic locations and 179 synaptic processes. SynGO annotations are exclusively based on published, expert-curated evidence. Using 2,922 annotations for 1,112 genes, we show that synaptic genes are exceptionally well conserved and less tolerant to mutations than other genes. Many SynGO terms are significantly overrepresented among gene variations associated with intelligence, educational attainment, ADHD, autism, and bipolar disorder and among de novo variants associated with neurodevelopmental disorders, including schizophrenia. SynGO is a public, universal reference for synapse research and an online analysis platform for interpretation of large-scale -omics data (https://syngoportal.org and http://geneontology.org).
AB - Synapses are fundamental information-processing units of the brain, and synaptic dysregulation is central to many brain disorders ("synaptopathies"). However, systematic annotation of synaptic genes and ontology of synaptic processes are currently lacking. We established SynGO, an interactive knowledge base that accumulates available research about synapse biology using Gene Ontology (GO) annotations to novel ontology terms: 87 synaptic locations and 179 synaptic processes. SynGO annotations are exclusively based on published, expert-curated evidence. Using 2,922 annotations for 1,112 genes, we show that synaptic genes are exceptionally well conserved and less tolerant to mutations than other genes. Many SynGO terms are significantly overrepresented among gene variations associated with intelligence, educational attainment, ADHD, autism, and bipolar disorder and among de novo variants associated with neurodevelopmental disorders, including schizophrenia. SynGO is a public, universal reference for synapse research and an online analysis platform for interpretation of large-scale -omics data (https://syngoportal.org and http://geneontology.org).
KW - Animals
KW - Brain/cytology
KW - Databases, Genetic
KW - Gene Ontology
KW - Humans
KW - Knowledge Bases
KW - Proteomics
KW - Software
KW - Synapses/physiology
KW - Synaptic Potentials/physiology
KW - Synaptosomes
U2 - 10.1016/j.neuron.2019.05.002
DO - 10.1016/j.neuron.2019.05.002
M3 - Journal article
C2 - 31171447
VL - 103
SP - 217-234.e4
JO - Neuron
JF - Neuron
SN - 0896-6273
IS - 2
ER -
