Striatal L-dopa decarboxylase activity in Parkinson's disease in vivo: implications for the regulation of dopamine synthesis.

Research output: Contribution to journal › Journal article › Research › peer-review

Standard

Striatal L-dopa decarboxylase activity in Parkinson's disease in vivo: implications for the regulation of dopamine synthesis. / Gjedde, A; Léger, G C; Cumming, P; Yasuhara, Y; Evans, A C; Guttman, M; Kuwabara, H.

In: Journal of Neurochemistry, Vol. 61, No. 4, 1993, p. 1538-41.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Gjedde, A, Léger, GC, Cumming, P, Yasuhara, Y, Evans, AC, Guttman, M & Kuwabara, H 1993, 'Striatal L-dopa decarboxylase activity in Parkinson's disease in vivo: implications for the regulation of dopamine synthesis.', Journal of Neurochemistry, vol. 61, no. 4, pp. 1538-41.

APA

Gjedde, A., Léger, G. C., Cumming, P., Yasuhara, Y., Evans, A. C., Guttman, M., & Kuwabara, H. (1993). Striatal L-dopa decarboxylase activity in Parkinson's disease in vivo: implications for the regulation of dopamine synthesis. Journal of Neurochemistry, 61(4), 1538-41.

Vancouver

Gjedde A, Léger GC, Cumming P, Yasuhara Y, Evans AC, Guttman M et al. Striatal L-dopa decarboxylase activity in Parkinson's disease in vivo: implications for the regulation of dopamine synthesis. Journal of Neurochemistry. 1993;61(4):1538-41.

Author

Gjedde, A ; Léger, G C ; Cumming, P ; Yasuhara, Y ; Evans, A C ; Guttman, M ; Kuwabara, H. / Striatal L-dopa decarboxylase activity in Parkinson's disease in vivo: implications for the regulation of dopamine synthesis. In: Journal of Neurochemistry. 1993 ; Vol. 61, No. 4. pp. 1538-41.

Bibtex

@article{14364680b31511debc73000ea68e967b,
title = "Striatal L-dopa decarboxylase activity in Parkinson's disease in vivo: implications for the regulation of dopamine synthesis.",
abstract = "L-DOPA is a large neutral amino acid subject to transport out of, as well as into, brain tissue. Competition between dopamine synthesis and L-DOPA egress from striatum must favor L-DOPA egress if decarboxylation declines relatively more than transport in Parkinson's disease. To test this hypothesis, we injected patients with Parkinson's disease with a radiolabeled analogue of L-DOPA and recorded regional brain radioactivity as a function of time by means of positron emission tomography. We simultaneously estimated the activity of the decarboxylating enzyme and the amino acid transport. In the striatum of patients, we found the L-DOPA decarboxylase activity to be reduced in the head of the caudate nucleus and the putamen. However, the rate of egress of the DOPA analogue was unaffected by the disease and thus inhibited dopamine synthesis more than predicted in the absence of L-DOPA egress.",
author = "A Gjedde and L{\'e}ger, {G C} and P Cumming and Y Yasuhara and Evans, {A C} and M Guttman and H Kuwabara",
year = "1993",
language = "English",
volume = "61",
pages = "1538--41",
journal = "Journal of Neurochemistry",
issn = "0022-3042",
publisher = "Wiley-Blackwell",
number = "4",

}

RIS

TY - JOUR

T1 - Striatal L-dopa decarboxylase activity in Parkinson's disease in vivo: implications for the regulation of dopamine synthesis.

AU - Gjedde, A

AU - Léger, G C

AU - Cumming, P

AU - Yasuhara, Y

AU - Evans, A C

AU - Guttman, M

AU - Kuwabara, H

PY - 1993

Y1 - 1993

N2 - L-DOPA is a large neutral amino acid subject to transport out of, as well as into, brain tissue. Competition between dopamine synthesis and L-DOPA egress from striatum must favor L-DOPA egress if decarboxylation declines relatively more than transport in Parkinson's disease. To test this hypothesis, we injected patients with Parkinson's disease with a radiolabeled analogue of L-DOPA and recorded regional brain radioactivity as a function of time by means of positron emission tomography. We simultaneously estimated the activity of the decarboxylating enzyme and the amino acid transport. In the striatum of patients, we found the L-DOPA decarboxylase activity to be reduced in the head of the caudate nucleus and the putamen. However, the rate of egress of the DOPA analogue was unaffected by the disease and thus inhibited dopamine synthesis more than predicted in the absence of L-DOPA egress.

AB - L-DOPA is a large neutral amino acid subject to transport out of, as well as into, brain tissue. Competition between dopamine synthesis and L-DOPA egress from striatum must favor L-DOPA egress if decarboxylation declines relatively more than transport in Parkinson's disease. To test this hypothesis, we injected patients with Parkinson's disease with a radiolabeled analogue of L-DOPA and recorded regional brain radioactivity as a function of time by means of positron emission tomography. We simultaneously estimated the activity of the decarboxylating enzyme and the amino acid transport. In the striatum of patients, we found the L-DOPA decarboxylase activity to be reduced in the head of the caudate nucleus and the putamen. However, the rate of egress of the DOPA analogue was unaffected by the disease and thus inhibited dopamine synthesis more than predicted in the absence of L-DOPA egress.

M3 - Journal article

C2 - 8377003

VL - 61

SP - 1538

EP - 1541

JO - Journal of Neurochemistry

JF - Journal of Neurochemistry

SN - 0022-3042

IS - 4

ER -

ID: 14944313