Spinal plasticity mediated by postsynaptic L-type Ca2+ channels
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Spinal plasticity mediated by postsynaptic L-type Ca2+ channels. / Perrier, Jean François; Alaburda, Aidas; Hounsgaard, Jørn.
In: Brain Research, Vol. 40, No. 1-3, 10.2002, p. 223-229.Research output: Contribution to journal › Review › Research › peer-review
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TY - JOUR
T1 - Spinal plasticity mediated by postsynaptic L-type Ca2+ channels
AU - Perrier, Jean François
AU - Alaburda, Aidas
AU - Hounsgaard, Jørn
PY - 2002/10
Y1 - 2002/10
N2 - In the spinal cord, motoneurons and specific subgroups of interneurons express L-type Ca2+ channels. As elsewhere, these dihydropyridine-sensitive channels mediate a slowly activating inward current in response to depolarisation and show little or no inactivation. The slow kinetics for activation and deactivation provide voltage-sensitive properties in a time range from hundreds of milliseconds to tens of seconds and lead to plateau potentials, bistability and wind-up in neurons in both sensory and motor networks. This slow dynamics is in part due to facilitation of L-type Ca2+ channels by depolarisation. The voltage sensitivity of L-type Ca2+ channels is also regulated by a range of metabotropic transmitter receptors. Up-regulation is mediated by receptors for glutamate, acetylcholine, noradrenaline and serotonin in motoneurons and by receptors for glutamate and substance P in plateau-generating dorsal horn interneurons. In both cell types, L-type Ca2+ channels are down-regulated by activation of GABAB receptors. In this way, metabotropic regulation in cells expressing L-type Ca2+ channels provides mechanisms for flexible adjustment of excitability and of the contribution of plateau currents to the intrinsic properties. This type of regulation also steers the magnitude and compartmental distribution of Ca2+ influx during depolarisation, thus providing a signal for local synaptic plasticity.
AB - In the spinal cord, motoneurons and specific subgroups of interneurons express L-type Ca2+ channels. As elsewhere, these dihydropyridine-sensitive channels mediate a slowly activating inward current in response to depolarisation and show little or no inactivation. The slow kinetics for activation and deactivation provide voltage-sensitive properties in a time range from hundreds of milliseconds to tens of seconds and lead to plateau potentials, bistability and wind-up in neurons in both sensory and motor networks. This slow dynamics is in part due to facilitation of L-type Ca2+ channels by depolarisation. The voltage sensitivity of L-type Ca2+ channels is also regulated by a range of metabotropic transmitter receptors. Up-regulation is mediated by receptors for glutamate, acetylcholine, noradrenaline and serotonin in motoneurons and by receptors for glutamate and substance P in plateau-generating dorsal horn interneurons. In both cell types, L-type Ca2+ channels are down-regulated by activation of GABAB receptors. In this way, metabotropic regulation in cells expressing L-type Ca2+ channels provides mechanisms for flexible adjustment of excitability and of the contribution of plateau currents to the intrinsic properties. This type of regulation also steers the magnitude and compartmental distribution of Ca2+ influx during depolarisation, thus providing a signal for local synaptic plasticity.
KW - Interneuron
KW - L-type Ca channels
KW - Modulation
KW - Motoneuron
KW - Plateau potential
KW - Spinal cord
UR - http://www.scopus.com/inward/record.url?scp=0036824827&partnerID=8YFLogxK
U2 - 10.1016/S0165-0173(02)00204-7
DO - 10.1016/S0165-0173(02)00204-7
M3 - Review
C2 - 12589920
AN - SCOPUS:0036824827
VL - 40
SP - 223
EP - 229
JO - Brain Research
JF - Brain Research
SN - 0006-8993
IS - 1-3
ER -
ID: 237698745