Spatially dissociated flow-metabolism coupling in brain activation

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Spatially dissociated flow-metabolism coupling in brain activation. / Vafaee, Manouchehr S; Gjedde, Albert.

In: NeuroImage, Vol. 21, No. 2, 2004, p. 507-15.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Vafaee, MS & Gjedde, A 2004, 'Spatially dissociated flow-metabolism coupling in brain activation', NeuroImage, vol. 21, no. 2, pp. 507-15. https://doi.org/10.1016/j.neuroimage.2003.10.003

APA

Vafaee, M. S., & Gjedde, A. (2004). Spatially dissociated flow-metabolism coupling in brain activation. NeuroImage, 21(2), 507-15. https://doi.org/10.1016/j.neuroimage.2003.10.003

Vancouver

Vafaee MS, Gjedde A. Spatially dissociated flow-metabolism coupling in brain activation. NeuroImage. 2004;21(2):507-15. https://doi.org/10.1016/j.neuroimage.2003.10.003

Author

Vafaee, Manouchehr S ; Gjedde, Albert. / Spatially dissociated flow-metabolism coupling in brain activation. In: NeuroImage. 2004 ; Vol. 21, No. 2. pp. 507-15.

Bibtex

@article{f2a019b0b31411debc73000ea68e967b,
title = "Spatially dissociated flow-metabolism coupling in brain activation",
abstract = "The relationships among cerebral blood flow (CBF), oxygen consumption (CMRO(2)) and glucose use (CMR(glc)) constitute the basis of functional brain-imaging. Here we report spatially dissociated changes of CMRO(2) and CBF during motor activity that lead us to propose a revision of conventional CBF-CMRO(2) coupling models. In the left primary and supplementary motor cortices, CBF and CMRO(2) rose significantly during finger-thumb tapping. However, in the right putamen CBF did not rise, despite a significant increase in CMRO(2). We explain these observations by invoking a central command mechanism that regulates CBF in the putamen in anticipation of movement. By this mechanism, CBF rose in the putamen before the measurements of CBF and CMRO(2) while CMRO(2) rose when actual motion commenced.",
author = "Vafaee, {Manouchehr S} and Albert Gjedde",
year = "2004",
doi = "10.1016/j.neuroimage.2003.10.003",
language = "English",
volume = "21",
pages = "507--15",
journal = "NeuroImage",
issn = "1053-8119",
publisher = "Elsevier",
number = "2",

}

RIS

TY - JOUR

T1 - Spatially dissociated flow-metabolism coupling in brain activation

AU - Vafaee, Manouchehr S

AU - Gjedde, Albert

PY - 2004

Y1 - 2004

N2 - The relationships among cerebral blood flow (CBF), oxygen consumption (CMRO(2)) and glucose use (CMR(glc)) constitute the basis of functional brain-imaging. Here we report spatially dissociated changes of CMRO(2) and CBF during motor activity that lead us to propose a revision of conventional CBF-CMRO(2) coupling models. In the left primary and supplementary motor cortices, CBF and CMRO(2) rose significantly during finger-thumb tapping. However, in the right putamen CBF did not rise, despite a significant increase in CMRO(2). We explain these observations by invoking a central command mechanism that regulates CBF in the putamen in anticipation of movement. By this mechanism, CBF rose in the putamen before the measurements of CBF and CMRO(2) while CMRO(2) rose when actual motion commenced.

AB - The relationships among cerebral blood flow (CBF), oxygen consumption (CMRO(2)) and glucose use (CMR(glc)) constitute the basis of functional brain-imaging. Here we report spatially dissociated changes of CMRO(2) and CBF during motor activity that lead us to propose a revision of conventional CBF-CMRO(2) coupling models. In the left primary and supplementary motor cortices, CBF and CMRO(2) rose significantly during finger-thumb tapping. However, in the right putamen CBF did not rise, despite a significant increase in CMRO(2). We explain these observations by invoking a central command mechanism that regulates CBF in the putamen in anticipation of movement. By this mechanism, CBF rose in the putamen before the measurements of CBF and CMRO(2) while CMRO(2) rose when actual motion commenced.

U2 - 10.1016/j.neuroimage.2003.10.003

DO - 10.1016/j.neuroimage.2003.10.003

M3 - Journal article

C2 - 14980553

VL - 21

SP - 507

EP - 515

JO - NeuroImage

JF - NeuroImage

SN - 1053-8119

IS - 2

ER -

ID: 14942688