Space-Time Dynamics of Membrane Currents Evolve to Shape Excitation, Spiking, and Inhibition in the Cortex at Small and Large Scales
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Space-Time Dynamics of Membrane Currents Evolve to Shape Excitation, Spiking, and Inhibition in the Cortex at Small and Large Scales. / Roland, Per E.
In: Neuron, Vol. 94, No. 5, 06.2017, p. 934-942.Research output: Contribution to journal › Review › Research › peer-review
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TY - JOUR
T1 - Space-Time Dynamics of Membrane Currents Evolve to Shape Excitation, Spiking, and Inhibition in the Cortex at Small and Large Scales
AU - Roland, Per E.
PY - 2017/6
Y1 - 2017/6
N2 - In the cerebral cortex, membrane currents, i.e., action potentials and other membrane currents, express many forms of space-time dynamics. In the spontaneous asynchronous irregular state, their space-time dynamics are local non-propagating fluctuations and sparse spiking appearing at unpredictable positions. After transition to active spiking states, larger structured zones with active spiking neurons appear, propagating through the cortical network, driving it into various forms of widespread excitation, and engaging the network from microscopic scales to whole cortical areas. At each engaged cortical site, the amount of excitation in the network, after a delay, becomes matched by an equal amount of space-time fine-tuned inhibition that might be instrumental in driving the dynamics toward perception and action.
AB - In the cerebral cortex, membrane currents, i.e., action potentials and other membrane currents, express many forms of space-time dynamics. In the spontaneous asynchronous irregular state, their space-time dynamics are local non-propagating fluctuations and sparse spiking appearing at unpredictable positions. After transition to active spiking states, larger structured zones with active spiking neurons appear, propagating through the cortical network, driving it into various forms of widespread excitation, and engaging the network from microscopic scales to whole cortical areas. At each engaged cortical site, the amount of excitation in the network, after a delay, becomes matched by an equal amount of space-time fine-tuned inhibition that might be instrumental in driving the dynamics toward perception and action.
KW - brain theory
KW - cerebral cortex
KW - dynamical brain states
KW - manifold
KW - network threshold
KW - object vision
KW - spike trains
KW - spontaneous activity
KW - transient network dynamics
KW - voluntary movements
U2 - 10.1016/j.neuron.2017.04.038
DO - 10.1016/j.neuron.2017.04.038
M3 - Review
C2 - 28595049
AN - SCOPUS:85020255160
VL - 94
SP - 934
EP - 942
JO - Neuron
JF - Neuron
SN - 0896-6273
IS - 5
ER -
ID: 193676396