Smoking normalizes cerebral blood flow and oxygen consumption after 12-hour abstention
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Smoking normalizes cerebral blood flow and oxygen consumption after 12-hour abstention. / Seyedi Vafaee, Manouchehr; Gjedde, Albert; Imamirad, Nasrin; Vang, Kim; Chakravarty, Mallar M.; Lerch, Jason P.; Cumming, Paul.
In: Journal of Cerebral Blood Flow and Metabolism, Vol. 35, No. 4, 04.2015, p. 699-705.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Smoking normalizes cerebral blood flow and oxygen consumption after 12-hour abstention
AU - Seyedi Vafaee, Manouchehr
AU - Gjedde, Albert
AU - Imamirad, Nasrin
AU - Vang, Kim
AU - Chakravarty, Mallar M.
AU - Lerch, Jason P.
AU - Cumming, Paul
PY - 2015/4
Y1 - 2015/4
N2 - Acute nicotine administration stimulates [14C]deoxyglucose trapping in thalamus and other regions of rat brain, but acute effects of nicotine and smoking on energy metabolism have rarely been investigated in human brain by positron emission tomography (PET). We obtained quantitative PET measurements of cerebral blood flow (CBF) and metabolic rate of oxygen (CMRO2) in 12 smokers who had refrained from smoking overnight, and in a historical group of nonsmokers, testing the prediction that overnight abstinence results in widespread, coupled reductions of CBF and CMRO2. At the end of the abstention period, global grey-matter CBF and CMRO2 were both reduced by 17% relative to nonsmokers. At 15 minutes after renewed smoking, global CBF had increased insignificantly, while global CMRO2 had increased by 11%. Regional analysis showed that CMRO2 had increased in the left putamen and thalamus, and in right posterior cortical regions at this time. At 60 and 105 minutes after smoking resumption, CBF had increased by 8% and CMRO2 had increased by 11–12%. Thus, we find substantial and global impairment of CBF/CMRO2 in abstaining smokers, and acute restoration by resumption of smoking. The reduced CBF and CMRO2 during acute abstention may mediate the cognitive changes described in chronic smokers.
AB - Acute nicotine administration stimulates [14C]deoxyglucose trapping in thalamus and other regions of rat brain, but acute effects of nicotine and smoking on energy metabolism have rarely been investigated in human brain by positron emission tomography (PET). We obtained quantitative PET measurements of cerebral blood flow (CBF) and metabolic rate of oxygen (CMRO2) in 12 smokers who had refrained from smoking overnight, and in a historical group of nonsmokers, testing the prediction that overnight abstinence results in widespread, coupled reductions of CBF and CMRO2. At the end of the abstention period, global grey-matter CBF and CMRO2 were both reduced by 17% relative to nonsmokers. At 15 minutes after renewed smoking, global CBF had increased insignificantly, while global CMRO2 had increased by 11%. Regional analysis showed that CMRO2 had increased in the left putamen and thalamus, and in right posterior cortical regions at this time. At 60 and 105 minutes after smoking resumption, CBF had increased by 8% and CMRO2 had increased by 11–12%. Thus, we find substantial and global impairment of CBF/CMRO2 in abstaining smokers, and acute restoration by resumption of smoking. The reduced CBF and CMRO2 during acute abstention may mediate the cognitive changes described in chronic smokers.
KW - metabolism
KW - nicotine
KW - oxygen
U2 - 10.1038/jcbfm.2014.246
DO - 10.1038/jcbfm.2014.246
M3 - Journal article
C2 - 25605288
VL - 35
SP - 699
EP - 705
JO - Journal of Cerebral Blood Flow and Metabolism
JF - Journal of Cerebral Blood Flow and Metabolism
SN - 0271-678X
IS - 4
ER -
ID: 160924822