Semi-quantitative theory of bistable dendrites with potential-dependent facilitation of inward current
Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review
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Semi-quantitative theory of bistable dendrites with potential-dependent facilitation of inward current. / Gutman, Aron; Baginskas, Armantas; Hounsgaard, Jorn; Svirskiene, Natasha; Svirskis, Gytis.
Modeling in the Neurosciences: From Biological Systems to Neuromimetic Robotics. CRC Press, 2005. p. 435-457.Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review
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TY - CHAP
T1 - Semi-quantitative theory of bistable dendrites with potential-dependent facilitation of inward current
AU - Gutman, Aron
AU - Baginskas, Armantas
AU - Hounsgaard, Jorn
AU - Svirskiene, Natasha
AU - Svirskis, Gytis
PY - 2005/1/1
Y1 - 2005/1/1
N2 - In many central neurons, including motoneurons, accommodation of the spike threshold is slow, partial, or absent (Bradley and Somjen, 1961; Koike et al., 1968; Schlue et al., 1974). This means that these cells possess a subthreshold slowly-or noninactivating inward current (Gutman, 1971). Noninactivating sodium currents (Magee and Johnston, 1995; Lipowsky et al., 1996; Schwindt and Crill, 1996) and calcium currents (Hounsgaard and Kiehn, 1993; Avery and Johnston, 1996; Magee et al., 1996; Hsiao et al., 1998; Morisset and Nagy, 1999) have been found in many nerve cells. These currents mediate slow dendritic spikes in many CNS neurons (Hounsgaard and Kiehn, 1993; Kim and Connors, 1993; Andreasen and Lambert, 1995; Schwindt and Crill, 1999), and plateau potentials in motoneurons (Hounsgaard and Kiehn, 1989; Hsiao et al., 1998; Lee and Heckman, 1998), Purkinje cells (Llinás and Sugimori, 1980a, 1980b), nociceptive deep dorsal horn neurons (Russo and Hounsgaard, 1994; Morisset and Nagy, 1998), neocortex pyramidal neurons (Schwindt and Crill, 1999), and striatal neurons (Dunia et al., 1996). In neurons bistability means that there is a net slow inward current that can cause a prolonged plateau potential without stimulation or active synaptic input. In bistable neurons the input current-voltage characteristic (I-Vin) is N-shaped and has two stable points of zero current.
AB - In many central neurons, including motoneurons, accommodation of the spike threshold is slow, partial, or absent (Bradley and Somjen, 1961; Koike et al., 1968; Schlue et al., 1974). This means that these cells possess a subthreshold slowly-or noninactivating inward current (Gutman, 1971). Noninactivating sodium currents (Magee and Johnston, 1995; Lipowsky et al., 1996; Schwindt and Crill, 1996) and calcium currents (Hounsgaard and Kiehn, 1993; Avery and Johnston, 1996; Magee et al., 1996; Hsiao et al., 1998; Morisset and Nagy, 1999) have been found in many nerve cells. These currents mediate slow dendritic spikes in many CNS neurons (Hounsgaard and Kiehn, 1993; Kim and Connors, 1993; Andreasen and Lambert, 1995; Schwindt and Crill, 1999), and plateau potentials in motoneurons (Hounsgaard and Kiehn, 1989; Hsiao et al., 1998; Lee and Heckman, 1998), Purkinje cells (Llinás and Sugimori, 1980a, 1980b), nociceptive deep dorsal horn neurons (Russo and Hounsgaard, 1994; Morisset and Nagy, 1998), neocortex pyramidal neurons (Schwindt and Crill, 1999), and striatal neurons (Dunia et al., 1996). In neurons bistability means that there is a net slow inward current that can cause a prolonged plateau potential without stimulation or active synaptic input. In bistable neurons the input current-voltage characteristic (I-Vin) is N-shaped and has two stable points of zero current.
UR - http://www.scopus.com/inward/record.url?scp=76449115198&partnerID=8YFLogxK
M3 - Book chapter
AN - SCOPUS:76449115198
SN - 0415328683
SN - 9780415328685
SP - 435
EP - 457
BT - Modeling in the Neurosciences
PB - CRC Press
ER -
ID: 237698496