Scotopic vision in the monkey is modulated by the G protein-coupled receptor 55

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Standard

Scotopic vision in the monkey is modulated by the G protein-coupled receptor 55. / Bouskila, Joseph; Harrar, Vanessa; Javadi, Pasha; Casanova, Christian; Hirabayashi, Yoshio; Matsuo, Ichiro; Ohyama, Jyunpei; Bouchard, Jean-Francois; Ptito, Maurice.

In: Visual Neuroscience, Vol. 33, E006, 01.2016.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Bouskila, J, Harrar, V, Javadi, P, Casanova, C, Hirabayashi, Y, Matsuo, I, Ohyama, J, Bouchard, J-F & Ptito, M 2016, 'Scotopic vision in the monkey is modulated by the G protein-coupled receptor 55', Visual Neuroscience, vol. 33, E006. https://doi.org/10.1017/S095252381600002X

APA

Bouskila, J., Harrar, V., Javadi, P., Casanova, C., Hirabayashi, Y., Matsuo, I., Ohyama, J., Bouchard, J-F., & Ptito, M. (2016). Scotopic vision in the monkey is modulated by the G protein-coupled receptor 55. Visual Neuroscience, 33, [E006]. https://doi.org/10.1017/S095252381600002X

Vancouver

Bouskila J, Harrar V, Javadi P, Casanova C, Hirabayashi Y, Matsuo I et al. Scotopic vision in the monkey is modulated by the G protein-coupled receptor 55. Visual Neuroscience. 2016 Jan;33. E006. https://doi.org/10.1017/S095252381600002X

Author

Bouskila, Joseph ; Harrar, Vanessa ; Javadi, Pasha ; Casanova, Christian ; Hirabayashi, Yoshio ; Matsuo, Ichiro ; Ohyama, Jyunpei ; Bouchard, Jean-Francois ; Ptito, Maurice. / Scotopic vision in the monkey is modulated by the G protein-coupled receptor 55. In: Visual Neuroscience. 2016 ; Vol. 33.

Bibtex

@article{8b3b36ef0c1747239da471b2403dce62,
title = "Scotopic vision in the monkey is modulated by the G protein-coupled receptor 55",
abstract = "The endogenous cannabinoid system plays important roles in the retina of mice and monkeys via their classic CB1 and CB2 receptors. We have previously reported that the G protein-coupled receptor 55 (GPR55), a putative cannabinoid receptor, is exclusively expressed in rod photoreceptors in the monkey retina, suggesting its possible role in scotopic vision. To test this hypothesis, we recorded full-field electroretinograms (ERGs) after the intravitreal injection of the GPR55 agonist lysophosphatidylglucoside (LPG) or the selective GPR55 antagonist CID16020046 (CID), under light- and dark-adapted conditions. Thirteen vervet monkeys (Chlorocebus sabaeus) were used in this study: four controls (injected with the vehicle dimethyl sulfoxide, DMSO), four injected with LPG and five with CID. We analyzed amplitudes and latencies of the a-wave (photoreceptor responses) and the b-wave (rod and cone system responses) of the ERG. Our results showed that after injection of LPG, the amplitude of the scotopic b-wave was significantly higher, whereas after the injection of CID, it was significantly decreased, compared to the vehicle (DMSO). On the other hand, the a-wave amplitude, and the a-wave and b-wave latencies, of the scotopic ERG responses were not significantly affected by the injection of either compound. Furthermore, the photopic ERG waveforms were not affected by either drug. These results support the hypothesis that GPR55 plays an instrumental role in mediating scotopic vision.",
keywords = "G protein-coupled receptor 55, LPG, CID16020046, Retina, Electroretinogram, Monkey",
author = "Joseph Bouskila and Vanessa Harrar and Pasha Javadi and Christian Casanova and Yoshio Hirabayashi and Ichiro Matsuo and Jyunpei Ohyama and Jean-Francois Bouchard and Maurice Ptito",
year = "2016",
month = jan,
doi = "10.1017/S095252381600002X",
language = "English",
volume = "33",
journal = "Visual Neuroscience",
issn = "0952-5238",
publisher = "Cambridge University Press",

}

RIS

TY - JOUR

T1 - Scotopic vision in the monkey is modulated by the G protein-coupled receptor 55

AU - Bouskila, Joseph

AU - Harrar, Vanessa

AU - Javadi, Pasha

AU - Casanova, Christian

AU - Hirabayashi, Yoshio

AU - Matsuo, Ichiro

AU - Ohyama, Jyunpei

AU - Bouchard, Jean-Francois

AU - Ptito, Maurice

PY - 2016/1

Y1 - 2016/1

N2 - The endogenous cannabinoid system plays important roles in the retina of mice and monkeys via their classic CB1 and CB2 receptors. We have previously reported that the G protein-coupled receptor 55 (GPR55), a putative cannabinoid receptor, is exclusively expressed in rod photoreceptors in the monkey retina, suggesting its possible role in scotopic vision. To test this hypothesis, we recorded full-field electroretinograms (ERGs) after the intravitreal injection of the GPR55 agonist lysophosphatidylglucoside (LPG) or the selective GPR55 antagonist CID16020046 (CID), under light- and dark-adapted conditions. Thirteen vervet monkeys (Chlorocebus sabaeus) were used in this study: four controls (injected with the vehicle dimethyl sulfoxide, DMSO), four injected with LPG and five with CID. We analyzed amplitudes and latencies of the a-wave (photoreceptor responses) and the b-wave (rod and cone system responses) of the ERG. Our results showed that after injection of LPG, the amplitude of the scotopic b-wave was significantly higher, whereas after the injection of CID, it was significantly decreased, compared to the vehicle (DMSO). On the other hand, the a-wave amplitude, and the a-wave and b-wave latencies, of the scotopic ERG responses were not significantly affected by the injection of either compound. Furthermore, the photopic ERG waveforms were not affected by either drug. These results support the hypothesis that GPR55 plays an instrumental role in mediating scotopic vision.

AB - The endogenous cannabinoid system plays important roles in the retina of mice and monkeys via their classic CB1 and CB2 receptors. We have previously reported that the G protein-coupled receptor 55 (GPR55), a putative cannabinoid receptor, is exclusively expressed in rod photoreceptors in the monkey retina, suggesting its possible role in scotopic vision. To test this hypothesis, we recorded full-field electroretinograms (ERGs) after the intravitreal injection of the GPR55 agonist lysophosphatidylglucoside (LPG) or the selective GPR55 antagonist CID16020046 (CID), under light- and dark-adapted conditions. Thirteen vervet monkeys (Chlorocebus sabaeus) were used in this study: four controls (injected with the vehicle dimethyl sulfoxide, DMSO), four injected with LPG and five with CID. We analyzed amplitudes and latencies of the a-wave (photoreceptor responses) and the b-wave (rod and cone system responses) of the ERG. Our results showed that after injection of LPG, the amplitude of the scotopic b-wave was significantly higher, whereas after the injection of CID, it was significantly decreased, compared to the vehicle (DMSO). On the other hand, the a-wave amplitude, and the a-wave and b-wave latencies, of the scotopic ERG responses were not significantly affected by the injection of either compound. Furthermore, the photopic ERG waveforms were not affected by either drug. These results support the hypothesis that GPR55 plays an instrumental role in mediating scotopic vision.

KW - G protein-coupled receptor 55

KW - LPG

KW - CID16020046

KW - Retina

KW - Electroretinogram

KW - Monkey

U2 - 10.1017/S095252381600002X

DO - 10.1017/S095252381600002X

M3 - Journal article

C2 - 27485069

VL - 33

JO - Visual Neuroscience

JF - Visual Neuroscience

SN - 0952-5238

M1 - E006

ER -

ID: 171660015