Regional brain volumes, diffusivity, and metabolite changes after electroconvulsive therapy for severe depression
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Regional brain volumes, diffusivity, and metabolite changes after electroconvulsive therapy for severe depression. / Jorgensen, A.; Magnusson, P; Hanson, Lars G.; Kirkegaard, T; Benveniste, H; Lee, H; Svarer, C; Mikkelsen, J D; Fink-Jensen, A; Knudsen, G M; Paulson, O B; Bolwig, T G; Jørgensen, Martin Balslev.
In: Acta Psychiatrica Scandinavica, Vol. 133, No. 2, 02.2016, p. 154-164.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Regional brain volumes, diffusivity, and metabolite changes after electroconvulsive therapy for severe depression
AU - Jorgensen, A.
AU - Magnusson, P
AU - Hanson, Lars G.
AU - Kirkegaard, T
AU - Benveniste, H
AU - Lee, H
AU - Svarer, C
AU - Mikkelsen, J D
AU - Fink-Jensen, A
AU - Knudsen, G M
AU - Paulson, O B
AU - Bolwig, T G
AU - Jørgensen, Martin Balslev
N1 - © 2015 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.
PY - 2016/2
Y1 - 2016/2
N2 - OBJECTIVE: To investigate the role of hippocampal plasticity in the antidepressant effect of electroconvulsive therapy (ECT).METHOD: We used magnetic resonance (MR) imaging including diffusion tensor imaging (DTI) and proton MR spectroscopy ((1) H-MRS) to investigate hippocampal volume, diffusivity, and metabolite changes in 19 patients receiving ECT for severe depression. Other regions of interest included the amygdala, dorsolateral prefrontal cortex (DLPFC), orbitofrontal cortex, and hypothalamus. Patients received a 3T MR scan before ECT (TP1), 1 week (TP2), and 4 weeks (TP3) after ECT.RESULTS: Hippocampal and amygdala volume increased significantly at TP2 and continued to be increased at TP3. DLPFC exhibited a transient volume reduction at TP2. DTI revealed a reduced anisotropy and diffusivity of the hippocampus at TP2. We found no significant post-ECT changes in brain metabolite concentrations, and we were unable to identify a spectral signature at ≈1.30 ppm previously suggested to reflect neurogenesis induced by ECT. None of the brain imaging measures correlated to the clinical response.CONCLUSION: Our findings show that ECT causes a remodeling of brain structures involved in affective regulation, but due to their lack of correlation with the antidepressant effect, this remodeling does not appear to be directly underlying the antidepressant action of ECT.
AB - OBJECTIVE: To investigate the role of hippocampal plasticity in the antidepressant effect of electroconvulsive therapy (ECT).METHOD: We used magnetic resonance (MR) imaging including diffusion tensor imaging (DTI) and proton MR spectroscopy ((1) H-MRS) to investigate hippocampal volume, diffusivity, and metabolite changes in 19 patients receiving ECT for severe depression. Other regions of interest included the amygdala, dorsolateral prefrontal cortex (DLPFC), orbitofrontal cortex, and hypothalamus. Patients received a 3T MR scan before ECT (TP1), 1 week (TP2), and 4 weeks (TP3) after ECT.RESULTS: Hippocampal and amygdala volume increased significantly at TP2 and continued to be increased at TP3. DLPFC exhibited a transient volume reduction at TP2. DTI revealed a reduced anisotropy and diffusivity of the hippocampus at TP2. We found no significant post-ECT changes in brain metabolite concentrations, and we were unable to identify a spectral signature at ≈1.30 ppm previously suggested to reflect neurogenesis induced by ECT. None of the brain imaging measures correlated to the clinical response.CONCLUSION: Our findings show that ECT causes a remodeling of brain structures involved in affective regulation, but due to their lack of correlation with the antidepressant effect, this remodeling does not appear to be directly underlying the antidepressant action of ECT.
U2 - 10.1111/acps.12462
DO - 10.1111/acps.12462
M3 - Journal article
C2 - 26138003
VL - 133
SP - 154
EP - 164
JO - Acta Psychiatrica Scandinavica
JF - Acta Psychiatrica Scandinavica
SN - 0001-690X
IS - 2
ER -
ID: 161988175