Reduction of common motoneuronal drive on the affected side during walking in hemiplegic stroke patients
Research output: Contribution to journal › Journal article › Research › peer-review
Standard
Reduction of common motoneuronal drive on the affected side during walking in hemiplegic stroke patients. / Nielsen, Jens Bo; Brittain, John-Stuart; Halliday, David M.; Marchand-Pauvert, Véronique; Mazevet, D.; Conway, Bernard A.
In: Clinical Neurophysiology, Vol. 119, No. 12, 2008, p. 2813-2818.Research output: Contribution to journal › Journal article › Research › peer-review
Harvard
APA
Vancouver
Author
Bibtex
}
RIS
TY - JOUR
T1 - Reduction of common motoneuronal drive on the affected side during walking in hemiplegic stroke patients
AU - Nielsen, Jens Bo
AU - Brittain, John-Stuart
AU - Halliday, David M.
AU - Marchand-Pauvert, Véronique
AU - Mazevet, D.
AU - Conway, Bernard A.
N1 - CURIS 2008 5200 145
PY - 2008
Y1 - 2008
N2 - OBJECTIVE: The objective of this study was to use motor unit coupling in the time and frequency domains to obtain evidence of changes in motoneuronal drive during walking in subjects with stroke. METHODS: Paired tibialis anterior (TA) EMG activity was sampled during the swing phase of treadmill walking in eight subjects with unilateral stroke. RESULTS: On the unaffected side, short-term synchronization was evident from the presence of a narrow central peak in cumulant densities and from the presence of significant coherence between these signals in the 10-25 Hz band. Such indicators of short-term synchrony were either absent or very small on the affected side. Instead, pronounced 10 Hz coupling was observed. CONCLUSIONS: It is suggested that reduced corticospinal drive to the spinal motoneurones is responsible for the reduced short-term synchrony and coherence in the 10-25 Hz frequency band on the affected side in hemiplegic patients during walking. SIGNIFICANCE: This is of importance for understanding the mechanisms responsible for reduced gait ability and development of new strategies for gait restoration.
AB - OBJECTIVE: The objective of this study was to use motor unit coupling in the time and frequency domains to obtain evidence of changes in motoneuronal drive during walking in subjects with stroke. METHODS: Paired tibialis anterior (TA) EMG activity was sampled during the swing phase of treadmill walking in eight subjects with unilateral stroke. RESULTS: On the unaffected side, short-term synchronization was evident from the presence of a narrow central peak in cumulant densities and from the presence of significant coherence between these signals in the 10-25 Hz band. Such indicators of short-term synchrony were either absent or very small on the affected side. Instead, pronounced 10 Hz coupling was observed. CONCLUSIONS: It is suggested that reduced corticospinal drive to the spinal motoneurones is responsible for the reduced short-term synchrony and coherence in the 10-25 Hz frequency band on the affected side in hemiplegic patients during walking. SIGNIFICANCE: This is of importance for understanding the mechanisms responsible for reduced gait ability and development of new strategies for gait restoration.
U2 - 10.1016/j.clinph.2008.07.283
DO - 10.1016/j.clinph.2008.07.283
M3 - Journal article
C2 - 18848803
VL - 119
SP - 2813
EP - 2818
JO - Clinical Neurophysiology
JF - Clinical Neurophysiology
SN - 1388-2457
IS - 12
ER -
ID: 9613930