Rapid steady-state analysis of blood-brain glucose transfer in rat.

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Rapid steady-state analysis of blood-brain glucose transfer in rat. / Gjedde, A.

In: Acta physiologica Scandinavica, Vol. 108, No. 4, 1980, p. 331-9.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Gjedde, A 1980, 'Rapid steady-state analysis of blood-brain glucose transfer in rat.', Acta physiologica Scandinavica, vol. 108, no. 4, pp. 331-9.

APA

Gjedde, A. (1980). Rapid steady-state analysis of blood-brain glucose transfer in rat. Acta physiologica Scandinavica, 108(4), 331-9.

Vancouver

Gjedde A. Rapid steady-state analysis of blood-brain glucose transfer in rat. Acta physiologica Scandinavica. 1980;108(4):331-9.

Author

Gjedde, A. / Rapid steady-state analysis of blood-brain glucose transfer in rat. In: Acta physiologica Scandinavica. 1980 ; Vol. 108, No. 4. pp. 331-9.

Bibtex

@article{363d3680b31511debc73000ea68e967b,
title = "Rapid steady-state analysis of blood-brain glucose transfer in rat.",
abstract = "A new kinetic analysis of blood-brain glucose transport is described, based on a steady-state model that takes account of cerebral blood flow, mean capillary glucose concentration, and cerebral metabolic rate. The maximal rate (Tmax) and half-saturation constant (Km) of glucose transport from blood to brain were determined in rats by measuring the rate of blood-to-brain glucose transfer at different blood glucose concentrations. Each determination lasted 20 seconds. For whole-brain, Tmax and Km averaged 258 +/- 33 (S.E.) mumol L(100 g)-1 min-1 and 5.9 +/- 1.6 (S.E.) mmol 1-1, respectively. The regional variations were insignificant. The new approach permits kinetic parameters to be measured locally in brain in rapidly changing functional states.",
author = "A Gjedde",
year = "1980",
language = "English",
volume = "108",
pages = "331--9",
journal = "Acta Physiologica Scandinavica",
issn = "0001-6772",
publisher = "Blackwell Science Ltd.",
number = "4",

}

RIS

TY - JOUR

T1 - Rapid steady-state analysis of blood-brain glucose transfer in rat.

AU - Gjedde, A

PY - 1980

Y1 - 1980

N2 - A new kinetic analysis of blood-brain glucose transport is described, based on a steady-state model that takes account of cerebral blood flow, mean capillary glucose concentration, and cerebral metabolic rate. The maximal rate (Tmax) and half-saturation constant (Km) of glucose transport from blood to brain were determined in rats by measuring the rate of blood-to-brain glucose transfer at different blood glucose concentrations. Each determination lasted 20 seconds. For whole-brain, Tmax and Km averaged 258 +/- 33 (S.E.) mumol L(100 g)-1 min-1 and 5.9 +/- 1.6 (S.E.) mmol 1-1, respectively. The regional variations were insignificant. The new approach permits kinetic parameters to be measured locally in brain in rapidly changing functional states.

AB - A new kinetic analysis of blood-brain glucose transport is described, based on a steady-state model that takes account of cerebral blood flow, mean capillary glucose concentration, and cerebral metabolic rate. The maximal rate (Tmax) and half-saturation constant (Km) of glucose transport from blood to brain were determined in rats by measuring the rate of blood-to-brain glucose transfer at different blood glucose concentrations. Each determination lasted 20 seconds. For whole-brain, Tmax and Km averaged 258 +/- 33 (S.E.) mumol L(100 g)-1 min-1 and 5.9 +/- 1.6 (S.E.) mmol 1-1, respectively. The regional variations were insignificant. The new approach permits kinetic parameters to be measured locally in brain in rapidly changing functional states.

M3 - Journal article

C2 - 6998256

VL - 108

SP - 331

EP - 339

JO - Acta Physiologica Scandinavica

JF - Acta Physiologica Scandinavica

SN - 0001-6772

IS - 4

ER -

ID: 14946154