Quantitative MRI and Clinical Assessment of Muscle Function in Adults With Cerebral Palsy
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Quantitative MRI and Clinical Assessment of Muscle Function in Adults With Cerebral Palsy. / Svane, Christian; Forman, Christian Riis; Rasul, Aqella; Nielsen, Christian Hammer; Nielsen, Jens Bo; Lorentzen, Jakob.
In: Frontiers in Neurology, Vol. 12, 771375, 2021.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Quantitative MRI and Clinical Assessment of Muscle Function in Adults With Cerebral Palsy
AU - Svane, Christian
AU - Forman, Christian Riis
AU - Rasul, Aqella
AU - Nielsen, Christian Hammer
AU - Nielsen, Jens Bo
AU - Lorentzen, Jakob
N1 - Copyright © 2021 Svane, Forman, Rasul, Nielsen, Nielsen and Lorentzen.
PY - 2021
Y1 - 2021
N2 - Aim: To relate quantitative magnetic resonance imaging (MRI) of ankle plantar flexor muscles to clinical functional tests in adults with cerebral palsy (CP) and neurologically intact (NI) adults. Methods: Eleven adults with CP (aged 41 ± 12, GMFCS level I-II) and 11 NI adults (aged 35 ± 10) participated in this case-control study. We used MRI to assess muscle volume and composition of the triceps surae muscles. We quantified muscle function as maximal voluntary plantarflexion (MVC) torque and countermovement jump (CMJ) height. Results: Compared to NI adults, the MRI intramuscular fat fraction estimate was significantly higher and MRI muscle volume and functional abilities (MVC and CMJ) significantly lower in adults with CP. In NI adults, but not adults with CP, MRI muscle volume correlated significantly with MVC and CMJ. In adults with CP, the estimate of intramuscular fat levels correlated significantly with jump height in a CMJ. Discussion: This study shows reduced muscle volume and altered muscle composition in adults with CP. Muscle composition appears to provide a better marker than muscle volume of reduced muscle function and impaired performance in this population. Measurements of muscle composition could be used in the assessment of neuromuscular impairments and in the determination of rehabilitation protocols in individuals with neurological disorders.
AB - Aim: To relate quantitative magnetic resonance imaging (MRI) of ankle plantar flexor muscles to clinical functional tests in adults with cerebral palsy (CP) and neurologically intact (NI) adults. Methods: Eleven adults with CP (aged 41 ± 12, GMFCS level I-II) and 11 NI adults (aged 35 ± 10) participated in this case-control study. We used MRI to assess muscle volume and composition of the triceps surae muscles. We quantified muscle function as maximal voluntary plantarflexion (MVC) torque and countermovement jump (CMJ) height. Results: Compared to NI adults, the MRI intramuscular fat fraction estimate was significantly higher and MRI muscle volume and functional abilities (MVC and CMJ) significantly lower in adults with CP. In NI adults, but not adults with CP, MRI muscle volume correlated significantly with MVC and CMJ. In adults with CP, the estimate of intramuscular fat levels correlated significantly with jump height in a CMJ. Discussion: This study shows reduced muscle volume and altered muscle composition in adults with CP. Muscle composition appears to provide a better marker than muscle volume of reduced muscle function and impaired performance in this population. Measurements of muscle composition could be used in the assessment of neuromuscular impairments and in the determination of rehabilitation protocols in individuals with neurological disorders.
U2 - 10.3389/fneur.2021.771375
DO - 10.3389/fneur.2021.771375
M3 - Journal article
C2 - 34858318
VL - 12
JO - Frontiers in Neurology
JF - Frontiers in Neurology
SN - 1664-2295
M1 - 771375
ER -
ID: 286993923