Presynaptic inhibitory action of acetylcholine in area CA1 of the hippocampus

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Standard

Presynaptic inhibitory action of acetylcholine in area CA1 of the hippocampus. / Hounsgaard, Jørn.

In: Experimental Neurology, Vol. 62, No. 3, 12.1978, p. 787-797.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Hounsgaard, J 1978, 'Presynaptic inhibitory action of acetylcholine in area CA1 of the hippocampus', Experimental Neurology, vol. 62, no. 3, pp. 787-797. https://doi.org/10.1016/0014-4886(78)90284-4

APA

Hounsgaard, J. (1978). Presynaptic inhibitory action of acetylcholine in area CA1 of the hippocampus. Experimental Neurology, 62(3), 787-797. https://doi.org/10.1016/0014-4886(78)90284-4

Vancouver

Hounsgaard J. Presynaptic inhibitory action of acetylcholine in area CA1 of the hippocampus. Experimental Neurology. 1978 Dec;62(3):787-797. https://doi.org/10.1016/0014-4886(78)90284-4

Author

Hounsgaard, Jørn. / Presynaptic inhibitory action of acetylcholine in area CA1 of the hippocampus. In: Experimental Neurology. 1978 ; Vol. 62, No. 3. pp. 787-797.

Bibtex

@article{24994772e9b14e5a87f0a09cc206d78d,
title = "Presynaptic inhibitory action of acetylcholine in area CA1 of the hippocampus",
abstract = "The effect of iontophoretically applied acetylcholin (ACh) was investigated in area CA1 of transverse hippocampal slices maintained in vitro. In synaptically activated regions of the dendritic field, ACh reduced the amplitude of the population spike recorded from the pyramidal layer. In dendritic regions which were not synaptically activated, ACh increased the amplitude of the population spike or it had no effect. The depressing effect of ACh was abolished in denervated dendritic regions. The intracellularly recorded excitatory postsynaptic potential (EPSP) decreased in amplitude when ACh was applied at the synaptic site. The resting membrane potential, the time course of the EPSP, and the membrane resistance were unaffected. ACh increased the excitability of afferent fibers and this was independent of synaptic transmission. We conclude that ACh in addition to its postsynaptic effects has a presynaptic site of action.",
author = "J{\o}rn Hounsgaard",
year = "1978",
month = dec,
doi = "10.1016/0014-4886(78)90284-4",
language = "English",
volume = "62",
pages = "787--797",
journal = "Experimental Neurology",
issn = "0014-4886",
publisher = "Academic Press",
number = "3",

}

RIS

TY - JOUR

T1 - Presynaptic inhibitory action of acetylcholine in area CA1 of the hippocampus

AU - Hounsgaard, Jørn

PY - 1978/12

Y1 - 1978/12

N2 - The effect of iontophoretically applied acetylcholin (ACh) was investigated in area CA1 of transverse hippocampal slices maintained in vitro. In synaptically activated regions of the dendritic field, ACh reduced the amplitude of the population spike recorded from the pyramidal layer. In dendritic regions which were not synaptically activated, ACh increased the amplitude of the population spike or it had no effect. The depressing effect of ACh was abolished in denervated dendritic regions. The intracellularly recorded excitatory postsynaptic potential (EPSP) decreased in amplitude when ACh was applied at the synaptic site. The resting membrane potential, the time course of the EPSP, and the membrane resistance were unaffected. ACh increased the excitability of afferent fibers and this was independent of synaptic transmission. We conclude that ACh in addition to its postsynaptic effects has a presynaptic site of action.

AB - The effect of iontophoretically applied acetylcholin (ACh) was investigated in area CA1 of transverse hippocampal slices maintained in vitro. In synaptically activated regions of the dendritic field, ACh reduced the amplitude of the population spike recorded from the pyramidal layer. In dendritic regions which were not synaptically activated, ACh increased the amplitude of the population spike or it had no effect. The depressing effect of ACh was abolished in denervated dendritic regions. The intracellularly recorded excitatory postsynaptic potential (EPSP) decreased in amplitude when ACh was applied at the synaptic site. The resting membrane potential, the time course of the EPSP, and the membrane resistance were unaffected. ACh increased the excitability of afferent fibers and this was independent of synaptic transmission. We conclude that ACh in addition to its postsynaptic effects has a presynaptic site of action.

UR - http://www.scopus.com/inward/record.url?scp=0018230405&partnerID=8YFLogxK

U2 - 10.1016/0014-4886(78)90284-4

DO - 10.1016/0014-4886(78)90284-4

M3 - Journal article

C2 - 750222

AN - SCOPUS:0018230405

VL - 62

SP - 787

EP - 797

JO - Experimental Neurology

JF - Experimental Neurology

SN - 0014-4886

IS - 3

ER -

ID: 237700765