PET studies of domoic acid poisoning in humans: excitotoxic destruction of brain glutamatergic pathways, revealed in measurements of glucose metabolism by positron emission tomography.
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PET studies of domoic acid poisoning in humans: excitotoxic destruction of brain glutamatergic pathways, revealed in measurements of glucose metabolism by positron emission tomography. / Gjedde, A; Evans, A C.
In: Canada diseases weekly report = Rapport hebdomadaire des maladies au Canada, Vol. 16 Suppl 1E, 1990, p. 105-9.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - PET studies of domoic acid poisoning in humans: excitotoxic destruction of brain glutamatergic pathways, revealed in measurements of glucose metabolism by positron emission tomography.
AU - Gjedde, A
AU - Evans, A C
PY - 1990
Y1 - 1990
N2 - We used positron emission tomography to measure hippocampal and medial temporal lobe metabolism in brains of patients intoxicated by domoic acid from Prince Edward Island mussels. This analog of kainic acid specifically excites certain neurons in the hippocampus, and the study revealed a severe reduction of glucose metabolism in this part of the brain which paralleled the absence of long-, medium-, or short-term memory in these patients.
AB - We used positron emission tomography to measure hippocampal and medial temporal lobe metabolism in brains of patients intoxicated by domoic acid from Prince Edward Island mussels. This analog of kainic acid specifically excites certain neurons in the hippocampus, and the study revealed a severe reduction of glucose metabolism in this part of the brain which paralleled the absence of long-, medium-, or short-term memory in these patients.
M3 - Journal article
C2 - 2101731
VL - 16 Suppl 1E
SP - 105
EP - 109
JO - Canada diseases weekly report
JF - Canada diseases weekly report
SN - 0382-232X
ER -
ID: 14946246