Pentobarbital anesthesia reduces blood-brain glucose transfer in the rat

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Standard

Pentobarbital anesthesia reduces blood-brain glucose transfer in the rat. / Gjedde, Albert; Rasmussen, Mette.

In: Journal of Neurochemistry, Vol. 35, No. 6, 1980, p. 1382-7.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Gjedde, A & Rasmussen, M 1980, 'Pentobarbital anesthesia reduces blood-brain glucose transfer in the rat', Journal of Neurochemistry, vol. 35, no. 6, pp. 1382-7.

APA

Gjedde, A., & Rasmussen, M. (1980). Pentobarbital anesthesia reduces blood-brain glucose transfer in the rat. Journal of Neurochemistry, 35(6), 1382-7.

Vancouver

Gjedde A, Rasmussen M. Pentobarbital anesthesia reduces blood-brain glucose transfer in the rat. Journal of Neurochemistry. 1980;35(6):1382-7.

Author

Gjedde, Albert ; Rasmussen, Mette. / Pentobarbital anesthesia reduces blood-brain glucose transfer in the rat. In: Journal of Neurochemistry. 1980 ; Vol. 35, No. 6. pp. 1382-7.

Bibtex

@article{1363db50b31511debc73000ea68e967b,
title = "Pentobarbital anesthesia reduces blood-brain glucose transfer in the rat",
abstract = "Pentobarbital anesthesia (40 mg kg-1) was accompanied by a 50% decrease of blood flow and a 40% decrease of unidirectional blood-brain glucose transfer in the parietal cortex of the rat brain. The correlation was explained by a decrease of the number of perfused capillaries. The maximal transport capacity, Tmax, decreased from 409 to 235 mumol 100 g-1 min-1 and the half-saturation constant, Km, from 8.8 to 4.9 mM. At 8.3-8.7 mM-glucose in arterial plasma, the transfer constant (clearance) for unidirectional blood-brain transfer decreased from 0.195 +/- 0.011 in awake rats to 0.132 +/- 0.005 ml g-1 min-1 in anesthetized rats. Half of the decrease was due to less complete diffusion-limitation of glucose uptake at the low plasma flow rate in brain, the other half to the decreased Tmax.",
author = "Albert Gjedde and Mette Rasmussen",
year = "1980",
language = "English",
volume = "35",
pages = "1382--7",
journal = "Journal of Neurochemistry",
issn = "0022-3042",
publisher = "Wiley-Blackwell",
number = "6",

}

RIS

TY - JOUR

T1 - Pentobarbital anesthesia reduces blood-brain glucose transfer in the rat

AU - Gjedde, Albert

AU - Rasmussen, Mette

PY - 1980

Y1 - 1980

N2 - Pentobarbital anesthesia (40 mg kg-1) was accompanied by a 50% decrease of blood flow and a 40% decrease of unidirectional blood-brain glucose transfer in the parietal cortex of the rat brain. The correlation was explained by a decrease of the number of perfused capillaries. The maximal transport capacity, Tmax, decreased from 409 to 235 mumol 100 g-1 min-1 and the half-saturation constant, Km, from 8.8 to 4.9 mM. At 8.3-8.7 mM-glucose in arterial plasma, the transfer constant (clearance) for unidirectional blood-brain transfer decreased from 0.195 +/- 0.011 in awake rats to 0.132 +/- 0.005 ml g-1 min-1 in anesthetized rats. Half of the decrease was due to less complete diffusion-limitation of glucose uptake at the low plasma flow rate in brain, the other half to the decreased Tmax.

AB - Pentobarbital anesthesia (40 mg kg-1) was accompanied by a 50% decrease of blood flow and a 40% decrease of unidirectional blood-brain glucose transfer in the parietal cortex of the rat brain. The correlation was explained by a decrease of the number of perfused capillaries. The maximal transport capacity, Tmax, decreased from 409 to 235 mumol 100 g-1 min-1 and the half-saturation constant, Km, from 8.8 to 4.9 mM. At 8.3-8.7 mM-glucose in arterial plasma, the transfer constant (clearance) for unidirectional blood-brain transfer decreased from 0.195 +/- 0.011 in awake rats to 0.132 +/- 0.005 ml g-1 min-1 in anesthetized rats. Half of the decrease was due to less complete diffusion-limitation of glucose uptake at the low plasma flow rate in brain, the other half to the decreased Tmax.

M3 - Journal article

C2 - 7441256

VL - 35

SP - 1382

EP - 1387

JO - Journal of Neurochemistry

JF - Journal of Neurochemistry

SN - 0022-3042

IS - 6

ER -

ID: 14944283