Oxygen consumption of the living human brain measured after a single inhalation of positron emitting oxygen.

Research output: Contribution to journal › Journal article › Research › peer-review

Standard

Oxygen consumption of the living human brain measured after a single inhalation of positron emitting oxygen. / Ohta, S; Meyer, E; Thompson, C J; Gjedde, A.

In: Journal of Cerebral Blood Flow and Metabolism, Vol. 12, No. 2, 1992, p. 179-92.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Ohta, S, Meyer, E, Thompson, CJ & Gjedde, A 1992, 'Oxygen consumption of the living human brain measured after a single inhalation of positron emitting oxygen.', Journal of Cerebral Blood Flow and Metabolism, vol. 12, no. 2, pp. 179-92.

APA

Ohta, S., Meyer, E., Thompson, C. J., & Gjedde, A. (1992). Oxygen consumption of the living human brain measured after a single inhalation of positron emitting oxygen. Journal of Cerebral Blood Flow and Metabolism, 12(2), 179-92.

Vancouver

Ohta S, Meyer E, Thompson CJ, Gjedde A. Oxygen consumption of the living human brain measured after a single inhalation of positron emitting oxygen. Journal of Cerebral Blood Flow and Metabolism. 1992;12(2):179-92.

Author

Ohta, S ; Meyer, E ; Thompson, C J ; Gjedde, A. / Oxygen consumption of the living human brain measured after a single inhalation of positron emitting oxygen. In: Journal of Cerebral Blood Flow and Metabolism. 1992 ; Vol. 12, No. 2. pp. 179-92.

Bibtex

@article{43c82990b31511debc73000ea68e967b,
title = "Oxygen consumption of the living human brain measured after a single inhalation of positron emitting oxygen.",
abstract = "We measured the rate of washout of 15O-labeled water generated from labeled oxygen accumulated in brain after bolus [15O]O2 inhalation, and compared the washout with that of labeled water measured with H215O. Contrary to the original expectation, the radioactive water generated from labeled oxygen failed to leave the brain tissue at the rate predicted by exogenous water. Therefore, the use of a separately measured value for exogenous water clearance led to an error in the calculation of oxygen consumption. A new method presented in this paper eliminated the error by yielding oxygen consumption in a single oxygen study. We used time-weighted integration to estimate three parameters, including the unidirectional clearance from blood to brain (KO2(1)), the fractional clearance of the distribution volume in brain (kO2(2)), and the vascular volume correction (VO). We showed that the clearance of oxygen from blood to brain can be estimated with acceptable precision by this new approach, and that the new method yields a reliable measure of oxygen consumption.",
author = "S Ohta and E Meyer and Thompson, {C J} and A Gjedde",
year = "1992",
language = "English",
volume = "12",
pages = "179--92",
journal = "Journal of Cerebral Blood Flow and Metabolism",
issn = "0271-678X",
publisher = "SAGE Publications",
number = "2",

}

RIS

TY - JOUR

T1 - Oxygen consumption of the living human brain measured after a single inhalation of positron emitting oxygen.

AU - Ohta, S

AU - Meyer, E

AU - Thompson, C J

AU - Gjedde, A

PY - 1992

Y1 - 1992

N2 - We measured the rate of washout of 15O-labeled water generated from labeled oxygen accumulated in brain after bolus [15O]O2 inhalation, and compared the washout with that of labeled water measured with H215O. Contrary to the original expectation, the radioactive water generated from labeled oxygen failed to leave the brain tissue at the rate predicted by exogenous water. Therefore, the use of a separately measured value for exogenous water clearance led to an error in the calculation of oxygen consumption. A new method presented in this paper eliminated the error by yielding oxygen consumption in a single oxygen study. We used time-weighted integration to estimate three parameters, including the unidirectional clearance from blood to brain (KO2(1)), the fractional clearance of the distribution volume in brain (kO2(2)), and the vascular volume correction (VO). We showed that the clearance of oxygen from blood to brain can be estimated with acceptable precision by this new approach, and that the new method yields a reliable measure of oxygen consumption.

AB - We measured the rate of washout of 15O-labeled water generated from labeled oxygen accumulated in brain after bolus [15O]O2 inhalation, and compared the washout with that of labeled water measured with H215O. Contrary to the original expectation, the radioactive water generated from labeled oxygen failed to leave the brain tissue at the rate predicted by exogenous water. Therefore, the use of a separately measured value for exogenous water clearance led to an error in the calculation of oxygen consumption. A new method presented in this paper eliminated the error by yielding oxygen consumption in a single oxygen study. We used time-weighted integration to estimate three parameters, including the unidirectional clearance from blood to brain (KO2(1)), the fractional clearance of the distribution volume in brain (kO2(2)), and the vascular volume correction (VO). We showed that the clearance of oxygen from blood to brain can be estimated with acceptable precision by this new approach, and that the new method yields a reliable measure of oxygen consumption.

M3 - Journal article

C2 - 1548291

VL - 12

SP - 179

EP - 192

JO - Journal of Cerebral Blood Flow and Metabolism

JF - Journal of Cerebral Blood Flow and Metabolism

SN - 0271-678X

IS - 2

ER -

ID: 14946882