Optogenetic control of human neurons in organotypic brain cultures
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Optogenetic control of human neurons in organotypic brain cultures. / Andersson, My; Avaliani, Natalia; Svensson, Andreas; Wickham, Jenny; Pinborg, Lars H; Jespersen, Bo; Christiansen, Søren H; Bengzon, Johan; Woldbye, David P D; Kokaia, Merab.
In: Scientific Reports, Vol. 6, 24818, 21.04.2016.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Optogenetic control of human neurons in organotypic brain cultures
AU - Andersson, My
AU - Avaliani, Natalia
AU - Svensson, Andreas
AU - Wickham, Jenny
AU - Pinborg, Lars H
AU - Jespersen, Bo
AU - Christiansen, Søren H
AU - Bengzon, Johan
AU - Woldbye, David P D
AU - Kokaia, Merab
PY - 2016/4/21
Y1 - 2016/4/21
N2 - Optogenetics is one of the most powerful tools in neuroscience, allowing for selective control of specific neuronal populations in the brain of experimental animals, including mammals. We report, for the first time, the application of optogenetic tools to human brain tissue providing a proof-of-concept for the use of optogenetics in neuromodulation of human cortical and hippocampal neurons as a possible tool to explore network mechanisms and develop future therapeutic strategies.
AB - Optogenetics is one of the most powerful tools in neuroscience, allowing for selective control of specific neuronal populations in the brain of experimental animals, including mammals. We report, for the first time, the application of optogenetic tools to human brain tissue providing a proof-of-concept for the use of optogenetics in neuromodulation of human cortical and hippocampal neurons as a possible tool to explore network mechanisms and develop future therapeutic strategies.
KW - Journal Article
KW - Research Support, Non-U.S. Gov't
U2 - 10.1038/srep24818
DO - 10.1038/srep24818
M3 - Journal article
C2 - 27098488
VL - 6
JO - Scientific Reports
JF - Scientific Reports
SN - 2045-2322
M1 - 24818
ER -
ID: 172391782