On the oxygenation of hemoglobin in the human brain.

Research output: Contribution to journal › Journal article › Research › peer-review

Standard

On the oxygenation of hemoglobin in the human brain. / Gjedde, A; Poulsen, P H; Østergaard, Leif.

In: Advances in Experimental Medicine and Biology, Vol. 471, 1999, p. 67-81.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Gjedde, A, Poulsen, PH & Østergaard, L 1999, 'On the oxygenation of hemoglobin in the human brain.', Advances in Experimental Medicine and Biology, vol. 471, pp. 67-81.

APA

Gjedde, A., Poulsen, P. H., & Østergaard, L. (1999). On the oxygenation of hemoglobin in the human brain. Advances in Experimental Medicine and Biology, 471, 67-81.

Vancouver

Gjedde A, Poulsen PH, Østergaard L. On the oxygenation of hemoglobin in the human brain. Advances in Experimental Medicine and Biology. 1999;471:67-81.

Author

Gjedde, A ; Poulsen, P H ; Østergaard, Leif. / On the oxygenation of hemoglobin in the human brain. In: Advances in Experimental Medicine and Biology. 1999 ; Vol. 471. pp. 67-81.

Bibtex

@article{2f3f5b60b31511debc73000ea68e967b,
title = "On the oxygenation of hemoglobin in the human brain.",
abstract = "We test three hypotheses arising from a model of oxygen delivery to brain tissue. The hypotheses claim that mitochondrial oxygen is negligible in brain tissue such that oxygen consumption depends solely on the mean capillary oxygen tension for a given capillary density; that capillary density is adjusted to satisfy the average steady-state oxygen requirement; and that sudden changes of brain function are subserved by changes of blood flow which adjust the mean capillary oxygen tension in the required direction. The results of the tests did not reject the two former hypotheses and only partly rejected the latter: Sudden changes of blood flow are not always accompanied by increases of oxygen consumption. When they are, changes of apparent capillary density (physiological recruitment) can occur.",
author = "A Gjedde and Poulsen, {P H} and Leif {\O}stergaard",
year = "1999",
language = "English",
volume = "471",
pages = "67--81",
journal = "Advances in Experimental Medicine and Biology",
issn = "0065-2598",
publisher = "Springer",

}

RIS

TY - JOUR

T1 - On the oxygenation of hemoglobin in the human brain.

AU - Gjedde, A

AU - Poulsen, P H

AU - Østergaard, Leif

PY - 1999

Y1 - 1999

N2 - We test three hypotheses arising from a model of oxygen delivery to brain tissue. The hypotheses claim that mitochondrial oxygen is negligible in brain tissue such that oxygen consumption depends solely on the mean capillary oxygen tension for a given capillary density; that capillary density is adjusted to satisfy the average steady-state oxygen requirement; and that sudden changes of brain function are subserved by changes of blood flow which adjust the mean capillary oxygen tension in the required direction. The results of the tests did not reject the two former hypotheses and only partly rejected the latter: Sudden changes of blood flow are not always accompanied by increases of oxygen consumption. When they are, changes of apparent capillary density (physiological recruitment) can occur.

AB - We test three hypotheses arising from a model of oxygen delivery to brain tissue. The hypotheses claim that mitochondrial oxygen is negligible in brain tissue such that oxygen consumption depends solely on the mean capillary oxygen tension for a given capillary density; that capillary density is adjusted to satisfy the average steady-state oxygen requirement; and that sudden changes of brain function are subserved by changes of blood flow which adjust the mean capillary oxygen tension in the required direction. The results of the tests did not reject the two former hypotheses and only partly rejected the latter: Sudden changes of blood flow are not always accompanied by increases of oxygen consumption. When they are, changes of apparent capillary density (physiological recruitment) can occur.

M3 - Journal article

C2 - 10659133

VL - 471

SP - 67

EP - 81

JO - Advances in Experimental Medicine and Biology

JF - Advances in Experimental Medicine and Biology

SN - 0065-2598

ER -

ID: 14945744