Night/day changes in pineal expression of >600 genes: central role of adrenergic/cAMP signaling
Research output: Contribution to journal › Journal article › Research › peer-review
The pineal gland plays an essential role in vertebrate chronobiology by converting time into a hormonal signal, melatonin, which is always elevated at night. Here we have analyzed the rodent pineal transcriptome using Affymetrix GeneChip(R) technology to obtain a more complete description of pineal cell biology. The effort revealed that 604 genes (1,268 probe sets) with Entrez Gene identifiers are differentially expressed greater than 2-fold between midnight and mid-day (false discovery rate
| Original language | English |
|---|---|
| Journal | Journal of Biological Chemistry |
| Volume | 284 |
| Issue number | 12 |
| Pages (from-to) | 7606-22 |
| Number of pages | 17 |
| ISSN | 0021-9258 |
| DOIs | |
| Publication status | Published - 2009 |
- Animals, Circadian Rhythm, Cyclic AMP, Gene Expression Profiling, Gene Expression Regulation, Norepinephrine, Oligonucleotide Array Sequence Analysis, Organ Specificity, Pineal Gland, Rats, Rats, Sprague-Dawley, Retina
Research areas
ID: 18316349