Nanostars Carrying Multifunctional Neurotrophic Dendrimers Protect Neurons in Preclinical In Vitro Models of Neurodegenerative Disorders

Research output: Contribution to journal › Journal article › Research › peer-review

Standard

Nanostars Carrying Multifunctional Neurotrophic Dendrimers Protect Neurons in Preclinical In Vitro Models of Neurodegenerative Disorders. / Morfill, Corinne; Pankratova, Stanislava; Machado, Pedro; Fernando, Nathalie K.; Regoutz, Anna; Talamona, Federica; Pinna, Alessandra; Klosowski, Michal; Wilkinson, Robert J.; Fleck, Roland A.; Xie, Fang; Porter, Alexandra E.; Kiryushko, Darya.

In: ACS applied materials & interfaces, Vol. 14, No. 42, 2022, p. 47445–47460.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Morfill, C, Pankratova, S, Machado, P, Fernando, NK, Regoutz, A, Talamona, F, Pinna, A, Klosowski, M, Wilkinson, RJ, Fleck, RA, Xie, F, Porter, AE & Kiryushko, D 2022, 'Nanostars Carrying Multifunctional Neurotrophic Dendrimers Protect Neurons in Preclinical In Vitro Models of Neurodegenerative Disorders', ACS applied materials & interfaces, vol. 14, no. 42, pp. 47445–47460. https://doi.org/10.1021/acsami.2c14220

APA

Morfill, C., Pankratova, S., Machado, P., Fernando, N. K., Regoutz, A., Talamona, F., Pinna, A., Klosowski, M., Wilkinson, R. J., Fleck, R. A., Xie, F., Porter, A. E., & Kiryushko, D. (2022). Nanostars Carrying Multifunctional Neurotrophic Dendrimers Protect Neurons in Preclinical In Vitro Models of Neurodegenerative Disorders. ACS applied materials & interfaces, 14(42), 47445–47460. https://doi.org/10.1021/acsami.2c14220

Vancouver

Morfill C, Pankratova S, Machado P, Fernando NK, Regoutz A, Talamona F et al. Nanostars Carrying Multifunctional Neurotrophic Dendrimers Protect Neurons in Preclinical In Vitro Models of Neurodegenerative Disorders. ACS applied materials & interfaces. 2022;14(42):47445–47460. https://doi.org/10.1021/acsami.2c14220

Author

Morfill, Corinne ; Pankratova, Stanislava ; Machado, Pedro ; Fernando, Nathalie K. ; Regoutz, Anna ; Talamona, Federica ; Pinna, Alessandra ; Klosowski, Michal ; Wilkinson, Robert J. ; Fleck, Roland A. ; Xie, Fang ; Porter, Alexandra E. ; Kiryushko, Darya. / Nanostars Carrying Multifunctional Neurotrophic Dendrimers Protect Neurons in Preclinical In Vitro Models of Neurodegenerative Disorders. In: ACS applied materials & interfaces. 2022 ; Vol. 14, No. 42. pp. 47445–47460.

Bibtex

@article{e48c1cae696343e9a511f0e0a3d176c6,
title = "Nanostars Carrying Multifunctional Neurotrophic Dendrimers Protect Neurons in Preclinical In Vitro Models of Neurodegenerative Disorders",
abstract = "A challenge in neurology is the lack of efficient brain-penetrable neuroprotectants targeting multiple disease mechanisms. Plasmonic gold nanostars are promising candidates to deliver standard-of-care drugs inside the brain but have not been trialed as carriers for neuroprotectants. Here, we conjugated custom-made peptide dendrimers (termed H3/H6), encompassing motifs of the neurotrophic S100A4-protein, onto star-shaped and spherical gold nanostructures (H3/H6-AuNS/AuNP) and evaluated their potential as neuroprotectants and interaction with neurons. The H3/H6 nanostructures crossed a model blood-brain barrier, bound to plasma membranes, and induced neuritogenesis with the AuNS, showing higher potency/ efficacy than the AuNP. The H3-AuNS/NP protected neurons against oxidative stress, the H3AuNS being more potent, and against Parkinson's or Alzheimer's disease (PD/AD)-related cytotoxicity. Unconjugated S100A4 motifs also decreased amyloid beta-induced neurodegeneration, introducing S100A4 as a player in AD. Using custom-made dendrimers coupled to star-shaped nanoparticles is a promising route to activate multiple",
keywords = "peptides, mimetic, neuron, gold nanostar, neuroprotection, DOPAMINERGIC CELL-DEATH, MTS1 S100A4 PROTEIN, BLOOD-BRAIN-BARRIER, GOLD NANOPARTICLES, OXIDATIVE STRESS, HIPPOCAMPAL-NEURONS, ALZHEIMERS-DISEASE, ERBB4 RECEPTOR, ANIMAL-MODEL, NEUREGULIN-1",
author = "Corinne Morfill and Stanislava Pankratova and Pedro Machado and Fernando, {Nathalie K.} and Anna Regoutz and Federica Talamona and Alessandra Pinna and Michal Klosowski and Wilkinson, {Robert J.} and Fleck, {Roland A.} and Fang Xie and Porter, {Alexandra E.} and Darya Kiryushko",
year = "2022",
doi = "10.1021/acsami.2c14220",
language = "English",
volume = "14",
pages = "47445–47460",
journal = "ACS applied materials & interfaces",
issn = "1944-8244",
publisher = "American Chemical Society",
number = "42",

}

RIS

TY - JOUR

T1 - Nanostars Carrying Multifunctional Neurotrophic Dendrimers Protect Neurons in Preclinical In Vitro Models of Neurodegenerative Disorders

AU - Morfill, Corinne

AU - Pankratova, Stanislava

AU - Machado, Pedro

AU - Fernando, Nathalie K.

AU - Regoutz, Anna

AU - Talamona, Federica

AU - Pinna, Alessandra

AU - Klosowski, Michal

AU - Wilkinson, Robert J.

AU - Fleck, Roland A.

AU - Xie, Fang

AU - Porter, Alexandra E.

AU - Kiryushko, Darya

PY - 2022

Y1 - 2022

N2 - A challenge in neurology is the lack of efficient brain-penetrable neuroprotectants targeting multiple disease mechanisms. Plasmonic gold nanostars are promising candidates to deliver standard-of-care drugs inside the brain but have not been trialed as carriers for neuroprotectants. Here, we conjugated custom-made peptide dendrimers (termed H3/H6), encompassing motifs of the neurotrophic S100A4-protein, onto star-shaped and spherical gold nanostructures (H3/H6-AuNS/AuNP) and evaluated their potential as neuroprotectants and interaction with neurons. The H3/H6 nanostructures crossed a model blood-brain barrier, bound to plasma membranes, and induced neuritogenesis with the AuNS, showing higher potency/ efficacy than the AuNP. The H3-AuNS/NP protected neurons against oxidative stress, the H3AuNS being more potent, and against Parkinson's or Alzheimer's disease (PD/AD)-related cytotoxicity. Unconjugated S100A4 motifs also decreased amyloid beta-induced neurodegeneration, introducing S100A4 as a player in AD. Using custom-made dendrimers coupled to star-shaped nanoparticles is a promising route to activate multiple

AB - A challenge in neurology is the lack of efficient brain-penetrable neuroprotectants targeting multiple disease mechanisms. Plasmonic gold nanostars are promising candidates to deliver standard-of-care drugs inside the brain but have not been trialed as carriers for neuroprotectants. Here, we conjugated custom-made peptide dendrimers (termed H3/H6), encompassing motifs of the neurotrophic S100A4-protein, onto star-shaped and spherical gold nanostructures (H3/H6-AuNS/AuNP) and evaluated their potential as neuroprotectants and interaction with neurons. The H3/H6 nanostructures crossed a model blood-brain barrier, bound to plasma membranes, and induced neuritogenesis with the AuNS, showing higher potency/ efficacy than the AuNP. The H3-AuNS/NP protected neurons against oxidative stress, the H3AuNS being more potent, and against Parkinson's or Alzheimer's disease (PD/AD)-related cytotoxicity. Unconjugated S100A4 motifs also decreased amyloid beta-induced neurodegeneration, introducing S100A4 as a player in AD. Using custom-made dendrimers coupled to star-shaped nanoparticles is a promising route to activate multiple

KW - peptides

KW - mimetic

KW - neuron

KW - gold nanostar

KW - neuroprotection

KW - DOPAMINERGIC CELL-DEATH

KW - MTS1 S100A4 PROTEIN

KW - BLOOD-BRAIN-BARRIER

KW - GOLD NANOPARTICLES

KW - OXIDATIVE STRESS

KW - HIPPOCAMPAL-NEURONS

KW - ALZHEIMERS-DISEASE

KW - ERBB4 RECEPTOR

KW - ANIMAL-MODEL

KW - NEUREGULIN-1

U2 - 10.1021/acsami.2c14220

DO - 10.1021/acsami.2c14220

M3 - Journal article

C2 - 36218307

VL - 14

SP - 47445

EP - 47460

JO - ACS applied materials & interfaces

JF - ACS applied materials & interfaces

SN - 1944-8244

IS - 42

ER -

ID: 323201334