Muscle growth is reduced in 15-month-old children with cerebral palsy
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Muscle growth is reduced in 15-month-old children with cerebral palsy. / Herskind, Anna; Ritterband-Rosenbaum, Anina; Willerslev-Olsen, Maria; Lorentzen, Jakob; Hanson, Lars; Lichtwark, Glen; Nielsen, Jens Bo.
In: Developmental Medicine and Child Neurology, Vol. 58, No. 5, 2016, p. 485-491.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Muscle growth is reduced in 15-month-old children with cerebral palsy
AU - Herskind, Anna
AU - Ritterband-Rosenbaum, Anina
AU - Willerslev-Olsen, Maria
AU - Lorentzen, Jakob
AU - Hanson, Lars
AU - Lichtwark, Glen
AU - Nielsen, Jens Bo
N1 - CURIS 2016 NEXS 112
PY - 2016
Y1 - 2016
N2 - AIM: Lack of muscle growth relative to bone growth may be responsible for development of contractures in children with cerebral palsy (CP). Here, we used ultrasonography to compare growth of the medial gastrocnemius muscle in children with and without CP.METHOD: Twenty-six children with spastic CP (15 males, 11 females; mean age 35mo, range 8-65mo) and 101 typically developing children (47 males, 54 females; mean age 29mo, range 1-69mo) were included. Functional abilities of children with CP equalled levels I to III in the Gross Motor Function Classification System. Medial gastrocnemius muscle volume was constructed from serial, transverse, two-dimensional ultrasonography images.RESULTS: In typically developing children, medial gastrocnemius volume increased linearly with age. Among children with CP, medial gastrocnemius volume increased less with age and deviated significantly from typically developing children at 15 months of age (p<0.05). Bone length increased with age without significant difference (p=0.49).INTERPRETATION: Muscle growth in children with CP initially follows that of typically developing children, but decreases at 15 months of age. This may be related to reduced physical activity and neural activation of the muscle. Interventions stimulating muscle growth in young children with CP may be important to prevent contractures.
AB - AIM: Lack of muscle growth relative to bone growth may be responsible for development of contractures in children with cerebral palsy (CP). Here, we used ultrasonography to compare growth of the medial gastrocnemius muscle in children with and without CP.METHOD: Twenty-six children with spastic CP (15 males, 11 females; mean age 35mo, range 8-65mo) and 101 typically developing children (47 males, 54 females; mean age 29mo, range 1-69mo) were included. Functional abilities of children with CP equalled levels I to III in the Gross Motor Function Classification System. Medial gastrocnemius muscle volume was constructed from serial, transverse, two-dimensional ultrasonography images.RESULTS: In typically developing children, medial gastrocnemius volume increased linearly with age. Among children with CP, medial gastrocnemius volume increased less with age and deviated significantly from typically developing children at 15 months of age (p<0.05). Bone length increased with age without significant difference (p=0.49).INTERPRETATION: Muscle growth in children with CP initially follows that of typically developing children, but decreases at 15 months of age. This may be related to reduced physical activity and neural activation of the muscle. Interventions stimulating muscle growth in young children with CP may be important to prevent contractures.
U2 - 10.1111/dmcn.12950
DO - 10.1111/dmcn.12950
M3 - Journal article
C2 - 26510820
VL - 58
SP - 485
EP - 491
JO - Developmental medicine and child neurology. Supplement
JF - Developmental medicine and child neurology. Supplement
SN - 0419-0238
IS - 5
ER -
ID: 147129392