Multiple Ca2+ sensors in secretion: teammates, competitors or autocrats?
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Multiple Ca2+ sensors in secretion : teammates, competitors or autocrats? / Walter, Alexander M; Groffen, Alexander J; Sørensen, Jakob Balslev; Verhage, Matthijs.
In: Trends in Neurosciences, Vol. 34, No. 9, 2011, p. 487-97.Research output: Contribution to journal › Review › Research › peer-review
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TY - JOUR
T1 - Multiple Ca2+ sensors in secretion
T2 - teammates, competitors or autocrats?
AU - Walter, Alexander M
AU - Groffen, Alexander J
AU - Sørensen, Jakob Balslev
AU - Verhage, Matthijs
N1 - Copyright © 2011 Elsevier Ltd. All rights reserved.
PY - 2011
Y1 - 2011
N2 - Regulated neurotransmitter secretion depends on Ca(2+) sensors, C2 domain proteins that associate with phospholipids and soluble N-ethylmaleimide-sensitive fusion attachment protein receptor (SNARE) complexes to trigger release upon Ca(2+) binding. Ca(2+) sensors are thought to prevent spontaneous fusion at rest (clamping) and to promote fusion upon Ca(2+) activation. At least eight, often coexpressed, Ca(2+) sensors have been identified in mammals. Accumulating evidence suggests that multiple Ca(2+) sensors interact, rather than work autonomously, to produce the complex secretory response observed in neurons and secretory cells. In this review, we present several working models to describe how different sensors might be arranged to mediate synchronous, asynchronous and spontaneous neurotransmitter release. We discuss the scenario that different Ca(2+) sensors typically act on one shared vesicle pool and compete for binding the multiple SNARE complexes that are likely to assemble at single vesicles, to exert both clamping and fusion-promoting functions.
AB - Regulated neurotransmitter secretion depends on Ca(2+) sensors, C2 domain proteins that associate with phospholipids and soluble N-ethylmaleimide-sensitive fusion attachment protein receptor (SNARE) complexes to trigger release upon Ca(2+) binding. Ca(2+) sensors are thought to prevent spontaneous fusion at rest (clamping) and to promote fusion upon Ca(2+) activation. At least eight, often coexpressed, Ca(2+) sensors have been identified in mammals. Accumulating evidence suggests that multiple Ca(2+) sensors interact, rather than work autonomously, to produce the complex secretory response observed in neurons and secretory cells. In this review, we present several working models to describe how different sensors might be arranged to mediate synchronous, asynchronous and spontaneous neurotransmitter release. We discuss the scenario that different Ca(2+) sensors typically act on one shared vesicle pool and compete for binding the multiple SNARE complexes that are likely to assemble at single vesicles, to exert both clamping and fusion-promoting functions.
KW - Animals
KW - Calcium
KW - Humans
KW - Membrane Fusion
KW - Neurons
KW - Neurotransmitter Agents
KW - Protein Structure, Tertiary
KW - SNARE Proteins
KW - Soluble N-Ethylmaleimide-Sensitive Factor Attachment Proteins
KW - Synapses
KW - Synaptic Transmission
KW - Synaptic Vesicles
U2 - 10.1016/j.tins.2011.07.003
DO - 10.1016/j.tins.2011.07.003
M3 - Review
C2 - 21831459
VL - 34
SP - 487
EP - 497
JO - Trends in Neurosciences
JF - Trends in Neurosciences
SN - 0378-5912
IS - 9
ER -
ID: 37830487