Multiple actions of iontophoretically applied serotonin on motorneurones in the turtle spinal cord in vitro

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Multiple actions of iontophoretically applied serotonin on motorneurones in the turtle spinal cord in vitro. / Skydsgaard, Morten Arnika; Hounsgaard, J.

In: Acta physiologica Scandinavica, Vol. 158, No. 4, 01.12.1996, p. 301-10.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Skydsgaard, MA & Hounsgaard, J 1996, 'Multiple actions of iontophoretically applied serotonin on motorneurones in the turtle spinal cord in vitro', Acta physiologica Scandinavica, vol. 158, no. 4, pp. 301-10.

APA

Skydsgaard, M. A., & Hounsgaard, J. (1996). Multiple actions of iontophoretically applied serotonin on motorneurones in the turtle spinal cord in vitro. Acta physiologica Scandinavica, 158(4), 301-10.

Vancouver

Skydsgaard MA, Hounsgaard J. Multiple actions of iontophoretically applied serotonin on motorneurones in the turtle spinal cord in vitro. Acta physiologica Scandinavica. 1996 Dec 1;158(4):301-10.

Author

Skydsgaard, Morten Arnika ; Hounsgaard, J. / Multiple actions of iontophoretically applied serotonin on motorneurones in the turtle spinal cord in vitro. In: Acta physiologica Scandinavica. 1996 ; Vol. 158, No. 4. pp. 301-10.

Bibtex

@article{88d21a9972934585845490df5fbd07fd,
title = "Multiple actions of iontophoretically applied serotonin on motorneurones in the turtle spinal cord in vitro",
abstract = "The effects of focal activation of serotonergic receptors in motorneurones were investigated in a slice preparation of the turtle spinal cord. The test response to glutamate evoked from a dendrite by iontophoresis was attenuated by serotonin or 8-hydroxy-dipropyl-aminotetralin (8-OH-DPAT) applied from an independent pipette within 100 microns of the glutamate pipette. This effect was not associated with a conductance change and did not affect glutamate responses evoked more than 100 microns from the serotonin pipette. The effect of serotonin was not reproduced by H+ ions. Plateau potentials were rarely facilitated by serotonin when applied in the dendritic field. Plateau potentials were readily facilitated by serotonin applied near the soma. This effect was preceded by attenuation of the slow after-hyperpolarization following an action potential. Applied near the soma, serotonin inhibited the response to a depolarizing current pulse of moderate strength and enhanced the response to a current pulse of high amplitude. These effects were associated with a conductance increase. We conclude that serotonin has spatially diverse effects on motorneurones.",
keywords = "Animals, Dendrites, Drug Interactions, Glutamic Acid, Iontophoresis, Motor Neurons, Serotonin, Spinal Cord",
author = "Skydsgaard, {Morten Arnika} and J Hounsgaard",
year = "1996",
month = dec,
day = "1",
language = "English",
volume = "158",
pages = "301--10",
journal = "Acta Physiologica Scandinavica",
issn = "0001-6772",
publisher = "Blackwell Science Ltd.",
number = "4",

}

RIS

TY - JOUR

T1 - Multiple actions of iontophoretically applied serotonin on motorneurones in the turtle spinal cord in vitro

AU - Skydsgaard, Morten Arnika

AU - Hounsgaard, J

PY - 1996/12/1

Y1 - 1996/12/1

N2 - The effects of focal activation of serotonergic receptors in motorneurones were investigated in a slice preparation of the turtle spinal cord. The test response to glutamate evoked from a dendrite by iontophoresis was attenuated by serotonin or 8-hydroxy-dipropyl-aminotetralin (8-OH-DPAT) applied from an independent pipette within 100 microns of the glutamate pipette. This effect was not associated with a conductance change and did not affect glutamate responses evoked more than 100 microns from the serotonin pipette. The effect of serotonin was not reproduced by H+ ions. Plateau potentials were rarely facilitated by serotonin when applied in the dendritic field. Plateau potentials were readily facilitated by serotonin applied near the soma. This effect was preceded by attenuation of the slow after-hyperpolarization following an action potential. Applied near the soma, serotonin inhibited the response to a depolarizing current pulse of moderate strength and enhanced the response to a current pulse of high amplitude. These effects were associated with a conductance increase. We conclude that serotonin has spatially diverse effects on motorneurones.

AB - The effects of focal activation of serotonergic receptors in motorneurones were investigated in a slice preparation of the turtle spinal cord. The test response to glutamate evoked from a dendrite by iontophoresis was attenuated by serotonin or 8-hydroxy-dipropyl-aminotetralin (8-OH-DPAT) applied from an independent pipette within 100 microns of the glutamate pipette. This effect was not associated with a conductance change and did not affect glutamate responses evoked more than 100 microns from the serotonin pipette. The effect of serotonin was not reproduced by H+ ions. Plateau potentials were rarely facilitated by serotonin when applied in the dendritic field. Plateau potentials were readily facilitated by serotonin applied near the soma. This effect was preceded by attenuation of the slow after-hyperpolarization following an action potential. Applied near the soma, serotonin inhibited the response to a depolarizing current pulse of moderate strength and enhanced the response to a current pulse of high amplitude. These effects were associated with a conductance increase. We conclude that serotonin has spatially diverse effects on motorneurones.

KW - Animals

KW - Dendrites

KW - Drug Interactions

KW - Glutamic Acid

KW - Iontophoresis

KW - Motor Neurons

KW - Serotonin

KW - Spinal Cord

M3 - Journal article

C2 - 8971250

VL - 158

SP - 301

EP - 310

JO - Acta Physiologica Scandinavica

JF - Acta Physiologica Scandinavica

SN - 0001-6772

IS - 4

ER -

ID: 33729529