Motor Neurons
Research output: Contribution to journal › Journal article › Research › peer-review
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Motor Neurons. / Hounsgaard, Jorn.
In: Comprehensive Physiology, Vol. 7, No. 2, 2017, p. 463-484.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Motor Neurons
AU - Hounsgaard, Jorn
PY - 2017
Y1 - 2017
N2 - Motor neurons translate synaptic input from widely distributed premotor networks into patterns of action potentials that orchestrate motor unit force and motor behavior. Intercalated between the CNS and muscles, motor neurons add to and adjust the final motor command. The identity and functional properties of this facility in the path from synaptic sites to the motor axon is reviewed with emphasis on voltage sensitive ion channels and regulatory metabotropic transmitter pathways. The catalog of the intrinsic response properties, their underlying mechanisms, and regulation obtained from motoneurons in in vitro preparations is far from complete. Nevertheless, a foundation has been provided for pursuing functional significance of intrinsic response properties in motoneurons in vivo during motor behavior at levels from molecules to systems.
AB - Motor neurons translate synaptic input from widely distributed premotor networks into patterns of action potentials that orchestrate motor unit force and motor behavior. Intercalated between the CNS and muscles, motor neurons add to and adjust the final motor command. The identity and functional properties of this facility in the path from synaptic sites to the motor axon is reviewed with emphasis on voltage sensitive ion channels and regulatory metabotropic transmitter pathways. The catalog of the intrinsic response properties, their underlying mechanisms, and regulation obtained from motoneurons in in vitro preparations is far from complete. Nevertheless, a foundation has been provided for pursuing functional significance of intrinsic response properties in motoneurons in vivo during motor behavior at levels from molecules to systems.
U2 - 10.1002/cphy.c160025
DO - 10.1002/cphy.c160025
M3 - Journal article
C2 - 28333379
VL - 7
SP - 463
EP - 484
JO - Comprehensive Physiology
JF - Comprehensive Physiology
SN - 2040-4603
IS - 2
ER -
ID: 182544050