Molecular Imaging of the Noradrenergic System in Idiopathic Parkinson's Disease

Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review

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Molecular Imaging of the Noradrenergic System in Idiopathic Parkinson's Disease. / Nahimi, Adjmal; Kinnerup, Martin B.; Sommerauer, Michael; Gjedde, Albert; Borghammer, Per.

International Review of Neurobiology. ed. / Marios Politis. Academic Press, 2018. p. 251-274 (International Review of Neurobiology, Vol. 141).

Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review

Harvard

Nahimi, A, Kinnerup, MB, Sommerauer, M, Gjedde, A & Borghammer, P 2018, Molecular Imaging of the Noradrenergic System in Idiopathic Parkinson's Disease. in M Politis (ed.), International Review of Neurobiology. Academic Press, International Review of Neurobiology, vol. 141, pp. 251-274. https://doi.org/10.1016/bs.irn.2018.07.028

APA

Nahimi, A., Kinnerup, M. B., Sommerauer, M., Gjedde, A., & Borghammer, P. (2018). Molecular Imaging of the Noradrenergic System in Idiopathic Parkinson's Disease. In M. Politis (Ed.), International Review of Neurobiology (pp. 251-274). Academic Press. International Review of Neurobiology Vol. 141 https://doi.org/10.1016/bs.irn.2018.07.028

Vancouver

Nahimi A, Kinnerup MB, Sommerauer M, Gjedde A, Borghammer P. Molecular Imaging of the Noradrenergic System in Idiopathic Parkinson's Disease. In Politis M, editor, International Review of Neurobiology. Academic Press. 2018. p. 251-274. (International Review of Neurobiology, Vol. 141). https://doi.org/10.1016/bs.irn.2018.07.028

Author

Nahimi, Adjmal ; Kinnerup, Martin B. ; Sommerauer, Michael ; Gjedde, Albert ; Borghammer, Per. / Molecular Imaging of the Noradrenergic System in Idiopathic Parkinson's Disease. International Review of Neurobiology. editor / Marios Politis. Academic Press, 2018. pp. 251-274 (International Review of Neurobiology, Vol. 141).

Bibtex

@inbook{a3685d16ab1f413ebc08d927274a43c7,
title = "Molecular Imaging of the Noradrenergic System in Idiopathic Parkinson's Disease",
abstract = "Noradrenergic neurons in both the peripheral nervous system and in the central nervous system (CNS) undergo severe degeneration in patients with Parkinson's disease (PD). This loss of noradrenaline may play essential roles in the occurrence of a wide range of prevalent non-motor symptoms and can further complicate the lives of PD patients. In vivo molecular imaging of noradrenaline may provide insights into to the extent of degeneration of noradrenergic neurons and subsequent depletion of noradrenergic projections. Molecular imaging methods exist to quantify the noradrenergic deficiency in peripheral autonomic terminals, such as [123I]-meta-iodobenzylguanidin scintigraphy of the heart. However, the degeneration of noradrenergic nuclei in the brainstem and their projections to the CNS has only been quantified with non-selective positron emission tomography ligands in previous studies. Here, we review recent advances in in vivo molecular imaging techniques that evaluate the role of deficits of noradrenaline in PD patients in the manifestation of motor and non-motor symptoms.",
keywords = "Adrenoceptors, Non-motor symptoms, Noradrenaline, Noradrenaline transporter, Parkinson's disease, Positron emission tomography",
author = "Adjmal Nahimi and Kinnerup, {Martin B.} and Michael Sommerauer and Albert Gjedde and Per Borghammer",
year = "2018",
doi = "10.1016/bs.irn.2018.07.028",
language = "English",
isbn = "9780128154182",
series = "International Review of Neurobiology",
publisher = "Academic Press",
pages = "251--274",
editor = "Marios Politis",
booktitle = "International Review of Neurobiology",
address = "United States",

}

RIS

TY - CHAP

T1 - Molecular Imaging of the Noradrenergic System in Idiopathic Parkinson's Disease

AU - Nahimi, Adjmal

AU - Kinnerup, Martin B.

AU - Sommerauer, Michael

AU - Gjedde, Albert

AU - Borghammer, Per

PY - 2018

Y1 - 2018

N2 - Noradrenergic neurons in both the peripheral nervous system and in the central nervous system (CNS) undergo severe degeneration in patients with Parkinson's disease (PD). This loss of noradrenaline may play essential roles in the occurrence of a wide range of prevalent non-motor symptoms and can further complicate the lives of PD patients. In vivo molecular imaging of noradrenaline may provide insights into to the extent of degeneration of noradrenergic neurons and subsequent depletion of noradrenergic projections. Molecular imaging methods exist to quantify the noradrenergic deficiency in peripheral autonomic terminals, such as [123I]-meta-iodobenzylguanidin scintigraphy of the heart. However, the degeneration of noradrenergic nuclei in the brainstem and their projections to the CNS has only been quantified with non-selective positron emission tomography ligands in previous studies. Here, we review recent advances in in vivo molecular imaging techniques that evaluate the role of deficits of noradrenaline in PD patients in the manifestation of motor and non-motor symptoms.

AB - Noradrenergic neurons in both the peripheral nervous system and in the central nervous system (CNS) undergo severe degeneration in patients with Parkinson's disease (PD). This loss of noradrenaline may play essential roles in the occurrence of a wide range of prevalent non-motor symptoms and can further complicate the lives of PD patients. In vivo molecular imaging of noradrenaline may provide insights into to the extent of degeneration of noradrenergic neurons and subsequent depletion of noradrenergic projections. Molecular imaging methods exist to quantify the noradrenergic deficiency in peripheral autonomic terminals, such as [123I]-meta-iodobenzylguanidin scintigraphy of the heart. However, the degeneration of noradrenergic nuclei in the brainstem and their projections to the CNS has only been quantified with non-selective positron emission tomography ligands in previous studies. Here, we review recent advances in in vivo molecular imaging techniques that evaluate the role of deficits of noradrenaline in PD patients in the manifestation of motor and non-motor symptoms.

KW - Adrenoceptors

KW - Non-motor symptoms

KW - Noradrenaline

KW - Noradrenaline transporter

KW - Parkinson's disease

KW - Positron emission tomography

U2 - 10.1016/bs.irn.2018.07.028

DO - 10.1016/bs.irn.2018.07.028

M3 - Book chapter

C2 - 30314598

AN - SCOPUS:85052092523

SN - 9780128154182

T3 - International Review of Neurobiology

SP - 251

EP - 274

BT - International Review of Neurobiology

A2 - Politis, Marios

PB - Academic Press

ER -

ID: 209804530