Modulation of respiratory frequency by peptidergic input to rhythmogenic neurons in the preBötzinger complex
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Modulation of respiratory frequency by peptidergic input to rhythmogenic neurons in the preBötzinger complex. / Gray, P A; Rekling, J C; Bocchiaro, C M; Feldman, J L.
In: Science, Vol. 286, No. 5444, 1999, p. 1566-8.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Modulation of respiratory frequency by peptidergic input to rhythmogenic neurons in the preBötzinger complex
AU - Gray, P A
AU - Rekling, J C
AU - Bocchiaro, C M
AU - Feldman, J L
N1 - Keywords: Animals; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Female; Medulla Oblongata; Mice; Mice, Inbred BALB C; Neurons; Rats; Rats, Sprague-Dawley; Receptors, GABA-B; Receptors, Neurokinin-1; Receptors, Opioid, mu; Respiratory Mechanics; Substance P; Synaptic Transmission
PY - 1999
Y1 - 1999
N2 - Neurokinin-1 receptor (NK1R) and mu-opioid receptor (muOR) agonists affected respiratory rhythm when injected directly into the preBötzinger Complex (preBötC), the hypothesized site for respiratory rhythmogenesis in mammals. These effects were mediated by actions on preBötC rhythmogenic neurons. The distribution of NK1R+ neurons anatomically defined the preBötC. Type 1 neurons in the preBötC, which have rhythmogenic properties, expressed both NK1Rs and muORs, whereas type 2 neurons expressed only NK1Rs. These findings suggest that the preBötC is a definable anatomic structure with unique physiological function and that a subpopulation of neurons expressing both NK1Rs and muORs generate respiratory rhythm and modulate respiratory frequency.
AB - Neurokinin-1 receptor (NK1R) and mu-opioid receptor (muOR) agonists affected respiratory rhythm when injected directly into the preBötzinger Complex (preBötC), the hypothesized site for respiratory rhythmogenesis in mammals. These effects were mediated by actions on preBötC rhythmogenic neurons. The distribution of NK1R+ neurons anatomically defined the preBötC. Type 1 neurons in the preBötC, which have rhythmogenic properties, expressed both NK1Rs and muORs, whereas type 2 neurons expressed only NK1Rs. These findings suggest that the preBötC is a definable anatomic structure with unique physiological function and that a subpopulation of neurons expressing both NK1Rs and muORs generate respiratory rhythm and modulate respiratory frequency.
M3 - Journal article
C2 - 10567264
VL - 286
SP - 1566
EP - 1568
JO - Science
JF - Science
SN - 0036-8075
IS - 5444
ER -
ID: 9255847