Modulation of anxiety circuits by serotonergic systems

Research output: Contribution to journal › Journal article › Research › peer-review

Standard

Modulation of anxiety circuits by serotonergic systems. / Lowry, Christopher A; Johnson, Philip L; Hay-Schmidt, Anders; Mikkelsen, Jens; Shekhar, Anantha.

In: Stress: The International Journal on the Biology of Stress , Vol. 8, No. 4, 12.2005, p. 233-246.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Lowry, CA, Johnson, PL, Hay-Schmidt, A, Mikkelsen, J & Shekhar, A 2005, 'Modulation of anxiety circuits by serotonergic systems', Stress: The International Journal on the Biology of Stress , vol. 8, no. 4, pp. 233-246. https://doi.org/10.1080/10253890500492787

APA

Lowry, C. A., Johnson, P. L., Hay-Schmidt, A., Mikkelsen, J., & Shekhar, A. (2005). Modulation of anxiety circuits by serotonergic systems. Stress: The International Journal on the Biology of Stress , 8(4), 233-246. https://doi.org/10.1080/10253890500492787

Vancouver

Lowry CA, Johnson PL, Hay-Schmidt A, Mikkelsen J, Shekhar A. Modulation of anxiety circuits by serotonergic systems. Stress: The International Journal on the Biology of Stress . 2005 Dec;8(4):233-246. https://doi.org/10.1080/10253890500492787

Author

Lowry, Christopher A ; Johnson, Philip L ; Hay-Schmidt, Anders ; Mikkelsen, Jens ; Shekhar, Anantha. / Modulation of anxiety circuits by serotonergic systems. In: Stress: The International Journal on the Biology of Stress . 2005 ; Vol. 8, No. 4. pp. 233-246.

Bibtex

@article{f4be53a06c3611dcbee902004c4f4f50,
title = "Modulation of anxiety circuits by serotonergic systems",
abstract = "Anxiety is a complex emotional state associated with sustained heightened autonomic and behavioral arousal and an increase in avoidance behavior. Anxiety-related behavior is a form of risk assessment behavior that is associated with a level of uncertainty or unpredictability regarding the outcome of emotionally salient events, often when both rewarding and aversive outcomes are possible. In this review, we highlight recent advances in our understanding of the neural circuits regulating anxiety states and anxiety-related behavior with an emphasis on the role of brainstem serotonergic systems in modulating anxiety-related circuits. In particular, we explore the possibility that the regulation of anxiety states and anxiety-related behavior by serotonergic systems is dependent on a specific, topographically organized mesolimbocortical serotonergic system that originates in the mid-rostrocaudal and caudal parts of the dorsal raphe nucleus.",
keywords = "Amygdala, Animals, Anxiety, Brain Mapping, Disease Models, Animal, Mental Disorders, Models, Biological, Neurons, Rats, Rats, Wistar, Serotonin, Serotonin Agents, Serotonin Antagonists, Serotonin Receptor Agonists",
author = "Lowry, {Christopher A} and Johnson, {Philip L} and Anders Hay-Schmidt and Jens Mikkelsen and Anantha Shekhar",
year = "2005",
month = dec,
doi = "10.1080/10253890500492787",
language = "English",
volume = "8",
pages = "233--246",
journal = "Stress: The International Journal on the Biology of Stress ",
issn = "1025-3890",
publisher = "Taylor & Francis",
number = "4",

}

RIS

TY - JOUR

T1 - Modulation of anxiety circuits by serotonergic systems

AU - Lowry, Christopher A

AU - Johnson, Philip L

AU - Hay-Schmidt, Anders

AU - Mikkelsen, Jens

AU - Shekhar, Anantha

PY - 2005/12

Y1 - 2005/12

N2 - Anxiety is a complex emotional state associated with sustained heightened autonomic and behavioral arousal and an increase in avoidance behavior. Anxiety-related behavior is a form of risk assessment behavior that is associated with a level of uncertainty or unpredictability regarding the outcome of emotionally salient events, often when both rewarding and aversive outcomes are possible. In this review, we highlight recent advances in our understanding of the neural circuits regulating anxiety states and anxiety-related behavior with an emphasis on the role of brainstem serotonergic systems in modulating anxiety-related circuits. In particular, we explore the possibility that the regulation of anxiety states and anxiety-related behavior by serotonergic systems is dependent on a specific, topographically organized mesolimbocortical serotonergic system that originates in the mid-rostrocaudal and caudal parts of the dorsal raphe nucleus.

AB - Anxiety is a complex emotional state associated with sustained heightened autonomic and behavioral arousal and an increase in avoidance behavior. Anxiety-related behavior is a form of risk assessment behavior that is associated with a level of uncertainty or unpredictability regarding the outcome of emotionally salient events, often when both rewarding and aversive outcomes are possible. In this review, we highlight recent advances in our understanding of the neural circuits regulating anxiety states and anxiety-related behavior with an emphasis on the role of brainstem serotonergic systems in modulating anxiety-related circuits. In particular, we explore the possibility that the regulation of anxiety states and anxiety-related behavior by serotonergic systems is dependent on a specific, topographically organized mesolimbocortical serotonergic system that originates in the mid-rostrocaudal and caudal parts of the dorsal raphe nucleus.

KW - Amygdala

KW - Animals

KW - Anxiety

KW - Brain Mapping

KW - Disease Models, Animal

KW - Mental Disorders

KW - Models, Biological

KW - Neurons

KW - Rats

KW - Rats, Wistar

KW - Serotonin

KW - Serotonin Agents

KW - Serotonin Antagonists

KW - Serotonin Receptor Agonists

U2 - 10.1080/10253890500492787

DO - 10.1080/10253890500492787

M3 - Journal article

C2 - 16423712

VL - 8

SP - 233

EP - 246

JO - Stress: The International Journal on the Biology of Stress

JF - Stress: The International Journal on the Biology of Stress

SN - 1025-3890

IS - 4

ER -

ID: 1092437