Modeling the spatial reach of the LFP
Research output: Contribution to journal › Journal article › Research › peer-review
Standard
Modeling the spatial reach of the LFP. / Lindén, Henrik; Tetzlaff, Tom; Potjans, Tobias C; Pettersen, Klas H; Grün, Sonja; Diesmann, Markus; Einevoll, Gaute T.
In: Neuron, Vol. 72, No. 5, 08.12.2011, p. 859-72.Research output: Contribution to journal › Journal article › Research › peer-review
Harvard
APA
Vancouver
Author
Bibtex
}
RIS
TY - JOUR
T1 - Modeling the spatial reach of the LFP
AU - Lindén, Henrik
AU - Tetzlaff, Tom
AU - Potjans, Tobias C
AU - Pettersen, Klas H
AU - Grün, Sonja
AU - Diesmann, Markus
AU - Einevoll, Gaute T
N1 - Copyright © 2011 Elsevier Inc. All rights reserved.
PY - 2011/12/8
Y1 - 2011/12/8
N2 - The local field potential (LFP) reflects activity of many neurons in the vicinity of the recording electrode and is therefore useful for studying local network dynamics. Much of the nature of the LFP is, however, still unknown. There are, for instance, contradicting reports on the spatial extent of the region generating the LFP. Here, we use a detailed biophysical modeling approach to investigate the size of the contributing region by simulating the LFP from a large number of neurons around the electrode. We find that the size of the generating region depends on the neuron morphology, the synapse distribution, and the correlation in synaptic activity. For uncorrelated activity, the LFP represents cells in a small region (within a radius of a few hundred micrometers). If the LFP contributions from different cells are correlated, the size of the generating region is determined by the spatial extent of the correlated activity.
AB - The local field potential (LFP) reflects activity of many neurons in the vicinity of the recording electrode and is therefore useful for studying local network dynamics. Much of the nature of the LFP is, however, still unknown. There are, for instance, contradicting reports on the spatial extent of the region generating the LFP. Here, we use a detailed biophysical modeling approach to investigate the size of the contributing region by simulating the LFP from a large number of neurons around the electrode. We find that the size of the generating region depends on the neuron morphology, the synapse distribution, and the correlation in synaptic activity. For uncorrelated activity, the LFP represents cells in a small region (within a radius of a few hundred micrometers). If the LFP contributions from different cells are correlated, the size of the generating region is determined by the spatial extent of the correlated activity.
KW - Animals
KW - Cerebral Cortex
KW - Computer Simulation
KW - Electrodes
KW - Electroencephalography
KW - Evoked Potentials
KW - Humans
KW - Models, Neurological
KW - Nerve Net
KW - Neurons
KW - Synapses
KW - Synaptic Potentials
U2 - 10.1016/j.neuron.2011.11.006
DO - 10.1016/j.neuron.2011.11.006
M3 - Journal article
C2 - 22153380
VL - 72
SP - 859
EP - 872
JO - Neuron
JF - Neuron
SN - 0896-6273
IS - 5
ER -
ID: 50204726