Midbrain circuits that set locomotor speed and gait selection
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Midbrain circuits that set locomotor speed and gait selection. / Caggiano, V.; Leiras, R.; Goñi-Erro, H.; Masini, D.; Bellardita, C.; Bouvier, J.; Caldeira, V.; Fisone, G.; Kiehn, O.
In: Nature, Vol. 553, No. 7689, 2018, p. 455-460.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Midbrain circuits that set locomotor speed and gait selection
AU - Caggiano, V.
AU - Leiras, R.
AU - Goñi-Erro, H.
AU - Masini, D.
AU - Bellardita, C.
AU - Bouvier, J.
AU - Caldeira, V.
AU - Fisone, G.
AU - Kiehn, O.
PY - 2018
Y1 - 2018
N2 - Locomotion is a fundamental motor function common to the animal kingdom. It is implemented episodically and adapted to behavioural needs, including exploration, which requires slow locomotion, and escape behaviour, which necessitates faster speeds. The control of these functions originates in brainstem structures, although the neuronal substrate(s) that support them have not yet been elucidated. Here we show in mice that speed and gait selection are controlled by glutamatergic excitatory neurons (GlutNs) segregated in two distinct midbrain nuclei: the cuneiform nucleus (CnF) and the pedunculopontine nucleus (PPN). GlutNs in both of these regions contribute to the control of slower, alternating-gait locomotion, whereas only GlutNs in the CnF are able to elicit high-speed, synchronous-gait locomotion. Additionally, both the activation dynamics and the input and output connectivity matrices of GlutNs in the PPN and the CnF support explorative and escape locomotion, respectively. Our results identify two regions in the midbrain that act in conjunction to select context-dependent locomotor behaviours.
AB - Locomotion is a fundamental motor function common to the animal kingdom. It is implemented episodically and adapted to behavioural needs, including exploration, which requires slow locomotion, and escape behaviour, which necessitates faster speeds. The control of these functions originates in brainstem structures, although the neuronal substrate(s) that support them have not yet been elucidated. Here we show in mice that speed and gait selection are controlled by glutamatergic excitatory neurons (GlutNs) segregated in two distinct midbrain nuclei: the cuneiform nucleus (CnF) and the pedunculopontine nucleus (PPN). GlutNs in both of these regions contribute to the control of slower, alternating-gait locomotion, whereas only GlutNs in the CnF are able to elicit high-speed, synchronous-gait locomotion. Additionally, both the activation dynamics and the input and output connectivity matrices of GlutNs in the PPN and the CnF support explorative and escape locomotion, respectively. Our results identify two regions in the midbrain that act in conjunction to select context-dependent locomotor behaviours.
U2 - 10.1038/nature25448
DO - 10.1038/nature25448
M3 - Journal article
C2 - 29342142
AN - SCOPUS:85041031041
VL - 553
SP - 455
EP - 460
JO - Nature
JF - Nature
SN - 0028-0836
IS - 7689
ER -
ID: 189356929