Melatonin and cortisol profiles in the absence of light perception
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Melatonin and cortisol profiles in the absence of light perception. / Aubin, S.; Kupers, R.; Ptito, M.; Jennum, P.
In: Behavioural Brain Research, Vol. 317, 15.01.2017, p. 515-521.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Melatonin and cortisol profiles in the absence of light perception
AU - Aubin, S.
AU - Kupers, R.
AU - Ptito, M.
AU - Jennum, P.
PY - 2017/1/15
Y1 - 2017/1/15
N2 - As light plays an important role in the synchronisation of the internal biological clock to the environmental day/night schedule, we compared the 24-h profiles of biological circadian markers in blind and normal sighted individuals. Salivary melatonin and cortisol concentrations were collected every two hours in eleven blind subjects, reporting no conscious light perception, and eleven age- and sex-matched normal sighted controls. Timing of melatonin onset and associated cortisol quiescence period confirm an increased incidence of abnormal circadian patterns in blindness. Additionally, blind subjects showed a greater overall melatonin concentration throughout the 24-h period. Cortisol profiles, including concentration and morning cortisol peaks, on the other hand, did not differ between blind and sighted individuals. These findings support previous reports of an increase in abnormal circadian rhythms and the absence of the entrainment properties of light in blindness.
AB - As light plays an important role in the synchronisation of the internal biological clock to the environmental day/night schedule, we compared the 24-h profiles of biological circadian markers in blind and normal sighted individuals. Salivary melatonin and cortisol concentrations were collected every two hours in eleven blind subjects, reporting no conscious light perception, and eleven age- and sex-matched normal sighted controls. Timing of melatonin onset and associated cortisol quiescence period confirm an increased incidence of abnormal circadian patterns in blindness. Additionally, blind subjects showed a greater overall melatonin concentration throughout the 24-h period. Cortisol profiles, including concentration and morning cortisol peaks, on the other hand, did not differ between blind and sighted individuals. These findings support previous reports of an increase in abnormal circadian rhythms and the absence of the entrainment properties of light in blindness.
KW - Blindness
KW - Cortisol
KW - Melatonin
KW - Circadian phase
KW - Sleep
U2 - 10.1016/j.bbr.2016.09.060
DO - 10.1016/j.bbr.2016.09.060
M3 - Journal article
C2 - 27693853
VL - 317
SP - 515
EP - 521
JO - Behavioural Brain Research
JF - Behavioural Brain Research
SN - 0166-4328
ER -
ID: 170736361