L-Type calcium channels but not N-methyl-D-aspartate receptor channels mediate rhythmic activity induced by cholinergic agonist in motoneurons from turtle spinal cord slices

Research output: Contribution to journal › Journal article › Research › peer-review

Standard

L-Type calcium channels but not N-methyl-D-aspartate receptor channels mediate rhythmic activity induced by cholinergic agonist in motoneurons from turtle spinal cord slices. / Guertin, P. A.; Hounsgaard, J.

In: Neuroscience Letters, Vol. 261, No. 1-2, 12.02.1999, p. 81-84.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Guertin, PA & Hounsgaard, J 1999, 'L-Type calcium channels but not N-methyl-D-aspartate receptor channels mediate rhythmic activity induced by cholinergic agonist in motoneurons from turtle spinal cord slices', Neuroscience Letters, vol. 261, no. 1-2, pp. 81-84. https://doi.org/10.1016/S0304-3940(99)00013-0

APA

Guertin, P. A., & Hounsgaard, J. (1999). L-Type calcium channels but not N-methyl-D-aspartate receptor channels mediate rhythmic activity induced by cholinergic agonist in motoneurons from turtle spinal cord slices. Neuroscience Letters, 261(1-2), 81-84. https://doi.org/10.1016/S0304-3940(99)00013-0

Vancouver

Guertin PA, Hounsgaard J. L-Type calcium channels but not N-methyl-D-aspartate receptor channels mediate rhythmic activity induced by cholinergic agonist in motoneurons from turtle spinal cord slices. Neuroscience Letters. 1999 Feb 12;261(1-2):81-84. https://doi.org/10.1016/S0304-3940(99)00013-0

Author

Guertin, P. A. ; Hounsgaard, J. / L-Type calcium channels but not N-methyl-D-aspartate receptor channels mediate rhythmic activity induced by cholinergic agonist in motoneurons from turtle spinal cord slices. In: Neuroscience Letters. 1999 ; Vol. 261, No. 1-2. pp. 81-84.

Bibtex

@article{928bc708eacf4b6ca434c85b68464942,
title = "L-Type calcium channels but not N-methyl-D-aspartate receptor channels mediate rhythmic activity induced by cholinergic agonist in motoneurons from turtle spinal cord slices",
abstract = "Rhythmic activity induced by different combinations of N-methyl-D- aspartate (NMDA), serotonin (5-HT), muscarine and D-tubocurarine was monitored intracellularly in lumbar motoneurons in a slice preparation from adult turtles. Low concentration of NMDA (7.5-15 μM) combined with 5-HT (10- 80 μM) induced rhythmic motoneuron discharge which was undefiled by intrinsic voltage oscillations resistant to tetrodotoxin. This oscillatory activity was abolished by 2-amino-5-phosphonopentanoic acid (AP5), a competitive blocker of NMDA receptors and by nifedipine a selective blocker of L-type calcium channels. In contrast, rhythmicity induced by the cholinergic agents muscarine and d-tubocurarine was abolished by nifedipine but not by AP5 nor by high [Mg2+]0. These results show that different receptor agonists induce intrinsic oscillations in mature motoneurons by independent routes. Each oscillatory mechanism depends on I-type calcium channels but only NMDA/5-HT-induced oscillations depend on voltage-sensitive NMDA-activated ionophores.",
keywords = "5-HT, Dihydropiridine, N-Methyl-d-aspartate, Spinal cord neuron",
author = "Guertin, {P. A.} and J. Hounsgaard",
year = "1999",
month = feb,
day = "12",
doi = "10.1016/S0304-3940(99)00013-0",
language = "English",
volume = "261",
pages = "81--84",
journal = "Neuroscience letters. Supplement",
issn = "0167-6253",
publisher = "Elsevier Ireland Ltd",
number = "1-2",

}

RIS

TY - JOUR

T1 - L-Type calcium channels but not N-methyl-D-aspartate receptor channels mediate rhythmic activity induced by cholinergic agonist in motoneurons from turtle spinal cord slices

AU - Guertin, P. A.

AU - Hounsgaard, J.

PY - 1999/2/12

Y1 - 1999/2/12

N2 - Rhythmic activity induced by different combinations of N-methyl-D- aspartate (NMDA), serotonin (5-HT), muscarine and D-tubocurarine was monitored intracellularly in lumbar motoneurons in a slice preparation from adult turtles. Low concentration of NMDA (7.5-15 μM) combined with 5-HT (10- 80 μM) induced rhythmic motoneuron discharge which was undefiled by intrinsic voltage oscillations resistant to tetrodotoxin. This oscillatory activity was abolished by 2-amino-5-phosphonopentanoic acid (AP5), a competitive blocker of NMDA receptors and by nifedipine a selective blocker of L-type calcium channels. In contrast, rhythmicity induced by the cholinergic agents muscarine and d-tubocurarine was abolished by nifedipine but not by AP5 nor by high [Mg2+]0. These results show that different receptor agonists induce intrinsic oscillations in mature motoneurons by independent routes. Each oscillatory mechanism depends on I-type calcium channels but only NMDA/5-HT-induced oscillations depend on voltage-sensitive NMDA-activated ionophores.

AB - Rhythmic activity induced by different combinations of N-methyl-D- aspartate (NMDA), serotonin (5-HT), muscarine and D-tubocurarine was monitored intracellularly in lumbar motoneurons in a slice preparation from adult turtles. Low concentration of NMDA (7.5-15 μM) combined with 5-HT (10- 80 μM) induced rhythmic motoneuron discharge which was undefiled by intrinsic voltage oscillations resistant to tetrodotoxin. This oscillatory activity was abolished by 2-amino-5-phosphonopentanoic acid (AP5), a competitive blocker of NMDA receptors and by nifedipine a selective blocker of L-type calcium channels. In contrast, rhythmicity induced by the cholinergic agents muscarine and d-tubocurarine was abolished by nifedipine but not by AP5 nor by high [Mg2+]0. These results show that different receptor agonists induce intrinsic oscillations in mature motoneurons by independent routes. Each oscillatory mechanism depends on I-type calcium channels but only NMDA/5-HT-induced oscillations depend on voltage-sensitive NMDA-activated ionophores.

KW - 5-HT

KW - Dihydropiridine

KW - N-Methyl-d-aspartate

KW - Spinal cord neuron

UR - http://www.scopus.com/inward/record.url?scp=0033548022&partnerID=8YFLogxK

U2 - 10.1016/S0304-3940(99)00013-0

DO - 10.1016/S0304-3940(99)00013-0

M3 - Journal article

C2 - 10081932

AN - SCOPUS:0033548022

VL - 261

SP - 81

EP - 84

JO - Neuroscience letters. Supplement

JF - Neuroscience letters. Supplement

SN - 0167-6253

IS - 1-2

ER -

ID: 237699073