Inhibition of motoneurons during the cutaneous silent period in the spinal cord of the turtle
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Inhibition of motoneurons during the cutaneous silent period in the spinal cord of the turtle. / Guzulaitis, Robertas; Hounsgaard, Jørn Dybkjær; Alaburda, Aidas.
In: Experimental Brain Research, Vol. 220, No. 1, 07.2012, p. 23-8.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Inhibition of motoneurons during the cutaneous silent period in the spinal cord of the turtle
AU - Guzulaitis, Robertas
AU - Hounsgaard, Jørn Dybkjær
AU - Alaburda, Aidas
PY - 2012/7
Y1 - 2012/7
N2 - The transient suppression of motor activity in the spinal cord after a cutaneous stimulus is termed the cutaneous silent period (CSP). It is not known if CSP is due to suppression of the premotor network or direct inhibition of motoneurons. This issue was examined by intracellular recordings from motoneurons in the isolated carapace-spinal cord preparation from adult turtles during rhythmic scratch-like reflex. Electrical stimulation of cutaneous nerves induced CSP-like suppression of motor nerve firing during rhythmic network activity. The stimulus that generated the CSP-like suppression of motor activity evokes a polysynaptic compound synaptic potential in motoneurons and suppressed their firing. This compound synaptic potential was hyperpolarizing near threshold for action potentials and was associated with a substantial increase in conductance during the CSP in the motor pool. These results show that direct postsynaptic inhibition of motoneurons contributes to the CSP.
AB - The transient suppression of motor activity in the spinal cord after a cutaneous stimulus is termed the cutaneous silent period (CSP). It is not known if CSP is due to suppression of the premotor network or direct inhibition of motoneurons. This issue was examined by intracellular recordings from motoneurons in the isolated carapace-spinal cord preparation from adult turtles during rhythmic scratch-like reflex. Electrical stimulation of cutaneous nerves induced CSP-like suppression of motor nerve firing during rhythmic network activity. The stimulus that generated the CSP-like suppression of motor activity evokes a polysynaptic compound synaptic potential in motoneurons and suppressed their firing. This compound synaptic potential was hyperpolarizing near threshold for action potentials and was associated with a substantial increase in conductance during the CSP in the motor pool. These results show that direct postsynaptic inhibition of motoneurons contributes to the CSP.
KW - Action Potentials
KW - Afferent Pathways
KW - Animals
KW - Biophysics
KW - Electric Stimulation
KW - Motor Neurons
KW - Neural Inhibition
KW - Patch-Clamp Techniques
KW - Physical Stimulation
KW - Reflex
KW - Refractory Period, Electrophysiological
KW - Skin
KW - Spinal Cord
KW - Turtles
U2 - 10.1007/s00221-012-3111-y
DO - 10.1007/s00221-012-3111-y
M3 - Journal article
C2 - 22580573
VL - 220
SP - 23
EP - 28
JO - Experimental Brain Research
JF - Experimental Brain Research
SN - 0014-4819
IS - 1
ER -
ID: 44756128