Increased turnover of dopamine in caudate nucleus of detoxified alcoholic patients
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Increased turnover of dopamine in caudate nucleus of detoxified alcoholic patients. / Kumakura, Yoshitaka; Gjedde, Albert; Caprioli, Daniele; Kienast, Thorsten; Beck, Anne; Plotkin, Michail; Schlagenhauf, Florian; Vernaleken, Ingo; Gründer, Gerhard; Bartenstein, Peter; Heinz, Andreas; Cumming, Paul.
In: PloS one, Vol. 8, No. 9, e73903, 2013, p. 1-7.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Increased turnover of dopamine in caudate nucleus of detoxified alcoholic patients
AU - Kumakura, Yoshitaka
AU - Gjedde, Albert
AU - Caprioli, Daniele
AU - Kienast, Thorsten
AU - Beck, Anne
AU - Plotkin, Michail
AU - Schlagenhauf, Florian
AU - Vernaleken, Ingo
AU - Gründer, Gerhard
AU - Bartenstein, Peter
AU - Heinz, Andreas
AU - Cumming, Paul
PY - 2013
Y1 - 2013
N2 - A previous study of the DOPA decarboxylase substrate 6-[(18)F]fluoro-L-DOPA (FDOPA) with positron emission tomography (PET) detected no difference of the net blood-brain transfer rate (Kin(app)) between detoxified alcoholic patients and healthy controls. Instead, the study revealed an inverse correlation between Kin (app) in left ventral striatum and alcohol craving scores. To resolve the influx and efflux phases of radiolabeled molecules, we independently estimated the unidirectional blood-brain FDOPA clearance rate (K) and the washout rate of [(18)F]fluorodopamine and its deaminated metabolites (k(loss)), and we also calculated the total distribution volume of decarboxylated metabolites and unmetabolized FDOPA as a steady-state index of the dopamine storage capacity (V(d)) in brain. The craving scores in the 12 alcoholics correlated positively with the rate of loss (k(loss)) in the left ventral striatum. We conclude that craving is most pronounced in the individuals with relatively rapid dopamine turnover in the left ventral striatum. The blood-brain clearance rate (K), corrected for subsequent loss of radiolabeled molecules from brain, was completely normal throughout the brain of the alcoholics, in whom the volume of distribution (V(d)) was found to be significantly lower in the left caudate nucleus. The magnitude of Vd in the left caudate head was reduced by 43% relative to the 16 controls, consistent with a 58% increase of k(loss). We interpret the findings as indicating that a trait for rapid dopamine turnover in the ventral striatum subserves craving and reward-dependence, leading to an acquired state of increased dopamine turnover in the dorsal striatum of detoxified alcoholic patients.
AB - A previous study of the DOPA decarboxylase substrate 6-[(18)F]fluoro-L-DOPA (FDOPA) with positron emission tomography (PET) detected no difference of the net blood-brain transfer rate (Kin(app)) between detoxified alcoholic patients and healthy controls. Instead, the study revealed an inverse correlation between Kin (app) in left ventral striatum and alcohol craving scores. To resolve the influx and efflux phases of radiolabeled molecules, we independently estimated the unidirectional blood-brain FDOPA clearance rate (K) and the washout rate of [(18)F]fluorodopamine and its deaminated metabolites (k(loss)), and we also calculated the total distribution volume of decarboxylated metabolites and unmetabolized FDOPA as a steady-state index of the dopamine storage capacity (V(d)) in brain. The craving scores in the 12 alcoholics correlated positively with the rate of loss (k(loss)) in the left ventral striatum. We conclude that craving is most pronounced in the individuals with relatively rapid dopamine turnover in the left ventral striatum. The blood-brain clearance rate (K), corrected for subsequent loss of radiolabeled molecules from brain, was completely normal throughout the brain of the alcoholics, in whom the volume of distribution (V(d)) was found to be significantly lower in the left caudate nucleus. The magnitude of Vd in the left caudate head was reduced by 43% relative to the 16 controls, consistent with a 58% increase of k(loss). We interpret the findings as indicating that a trait for rapid dopamine turnover in the ventral striatum subserves craving and reward-dependence, leading to an acquired state of increased dopamine turnover in the dorsal striatum of detoxified alcoholic patients.
KW - Adult
KW - Alcoholism
KW - Brain Mapping
KW - Caudate Nucleus
KW - Dopamine
KW - Functional Laterality
KW - Humans
KW - Male
KW - Middle Aged
KW - Positron-Emission Tomography
U2 - 10.1371/journal.pone.0073903
DO - 10.1371/journal.pone.0073903
M3 - Journal article
C2 - 24040111
VL - 8
SP - 1
EP - 7
JO - PLoS ONE
JF - PLoS ONE
SN - 1932-6203
IS - 9
M1 - e73903
ER -
ID: 118394528