Increased serum brain-derived neurotrophic factor (BDNF) levels in patients with narcolepsy

Research output: Contribution to journal › Journal article › Research › peer-review

Standard

Increased serum brain-derived neurotrophic factor (BDNF) levels in patients with narcolepsy. / Klein, Anders B; Jennum, Poul; Knudsen, Stine; Gammeltoft, Steen; Mikkelsen, Jens D.

In: Neuroscience Letters, Vol. 544, 07.06.2013, p. 31-35.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Klein, AB, Jennum, P, Knudsen, S, Gammeltoft, S & Mikkelsen, JD 2013, 'Increased serum brain-derived neurotrophic factor (BDNF) levels in patients with narcolepsy', Neuroscience Letters, vol. 544, pp. 31-35. https://doi.org/10.1016/j.neulet.2013.03.031

APA

Klein, A. B., Jennum, P., Knudsen, S., Gammeltoft, S., & Mikkelsen, J. D. (2013). Increased serum brain-derived neurotrophic factor (BDNF) levels in patients with narcolepsy. Neuroscience Letters, 544, 31-35. https://doi.org/10.1016/j.neulet.2013.03.031

Vancouver

Klein AB, Jennum P, Knudsen S, Gammeltoft S, Mikkelsen JD. Increased serum brain-derived neurotrophic factor (BDNF) levels in patients with narcolepsy. Neuroscience Letters. 2013 Jun 7;544:31-35. https://doi.org/10.1016/j.neulet.2013.03.031

Author

Klein, Anders B ; Jennum, Poul ; Knudsen, Stine ; Gammeltoft, Steen ; Mikkelsen, Jens D. / Increased serum brain-derived neurotrophic factor (BDNF) levels in patients with narcolepsy. In: Neuroscience Letters. 2013 ; Vol. 544. pp. 31-35.

Bibtex

@article{67e76dbe0e274b8bac5c6a2385712313,
title = "Increased serum brain-derived neurotrophic factor (BDNF) levels in patients with narcolepsy",
abstract = "Narcolepsy is a lifelong sleep disorder characterized by excessive daytime sleepiness, sudden loss of muscle tone (cataplexy), fragmentation of nocturnal sleep and sleep paralysis. The symptoms of the disease strongly correlate with a reduction in hypocretin levels in CSF and a reduction in hypocretin neurons in hypothalamus in post-mortem tissue. Brain-derived neurotrophic factor (BDNF) and nerve growth factor (NGF) are important for activity-dependent neuronal function and synaptic modulation and it is considered that these mechanisms are important in sleep regulation. We hypothesised that serum levels of these factors are altered in patients with narcolepsy compared to healthy controls without sleep disturbances. Polysomnography data was obtained and serum BDNF and NGF levels measured using ELISA, while hypocretin was measured using RIA. Serum BDNF levels were significantly higher in narcolepsy patients than in healthy controls (64.2±3.9ng/ml vs 47.3±2.6ng/ml, P",
author = "Klein, {Anders B} and Poul Jennum and Stine Knudsen and Steen Gammeltoft and Mikkelsen, {Jens D}",
year = "2013",
month = jun,
day = "7",
doi = "10.1016/j.neulet.2013.03.031",
language = "English",
volume = "544",
pages = "31--35",
journal = "Neuroscience letters. Supplement",
issn = "0167-6253",
publisher = "Elsevier Ireland Ltd",

}

RIS

TY - JOUR

T1 - Increased serum brain-derived neurotrophic factor (BDNF) levels in patients with narcolepsy

AU - Klein, Anders B

AU - Jennum, Poul

AU - Knudsen, Stine

AU - Gammeltoft, Steen

AU - Mikkelsen, Jens D

PY - 2013/6/7

Y1 - 2013/6/7

N2 - Narcolepsy is a lifelong sleep disorder characterized by excessive daytime sleepiness, sudden loss of muscle tone (cataplexy), fragmentation of nocturnal sleep and sleep paralysis. The symptoms of the disease strongly correlate with a reduction in hypocretin levels in CSF and a reduction in hypocretin neurons in hypothalamus in post-mortem tissue. Brain-derived neurotrophic factor (BDNF) and nerve growth factor (NGF) are important for activity-dependent neuronal function and synaptic modulation and it is considered that these mechanisms are important in sleep regulation. We hypothesised that serum levels of these factors are altered in patients with narcolepsy compared to healthy controls without sleep disturbances. Polysomnography data was obtained and serum BDNF and NGF levels measured using ELISA, while hypocretin was measured using RIA. Serum BDNF levels were significantly higher in narcolepsy patients than in healthy controls (64.2±3.9ng/ml vs 47.3±2.6ng/ml, P

AB - Narcolepsy is a lifelong sleep disorder characterized by excessive daytime sleepiness, sudden loss of muscle tone (cataplexy), fragmentation of nocturnal sleep and sleep paralysis. The symptoms of the disease strongly correlate with a reduction in hypocretin levels in CSF and a reduction in hypocretin neurons in hypothalamus in post-mortem tissue. Brain-derived neurotrophic factor (BDNF) and nerve growth factor (NGF) are important for activity-dependent neuronal function and synaptic modulation and it is considered that these mechanisms are important in sleep regulation. We hypothesised that serum levels of these factors are altered in patients with narcolepsy compared to healthy controls without sleep disturbances. Polysomnography data was obtained and serum BDNF and NGF levels measured using ELISA, while hypocretin was measured using RIA. Serum BDNF levels were significantly higher in narcolepsy patients than in healthy controls (64.2±3.9ng/ml vs 47.3±2.6ng/ml, P

U2 - 10.1016/j.neulet.2013.03.031

DO - 10.1016/j.neulet.2013.03.031

M3 - Journal article

C2 - 23570723

VL - 544

SP - 31

EP - 35

JO - Neuroscience letters. Supplement

JF - Neuroscience letters. Supplement

SN - 0167-6253

ER -

ID: 117978450