In vivo brain temperature mapping using polymer optical fiber Bragg grating sensors
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In vivo brain temperature mapping using polymer optical fiber Bragg grating sensors. / Sui, Kunyang; Meneghetti, Marcello; Li, Guanghui; Ioannou, Andreas; Abdollahian, Parinaz; Kalli, Kyriacos; Nielsen, Kristian; Berg, Rune W.; Markos, Christos.
In: Optics Letters, Vol. 48, No. 16, 2023, p. 4225-4228.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - In vivo brain temperature mapping using polymer optical fiber Bragg grating sensors
AU - Sui, Kunyang
AU - Meneghetti, Marcello
AU - Li, Guanghui
AU - Ioannou, Andreas
AU - Abdollahian, Parinaz
AU - Kalli, Kyriacos
AU - Nielsen, Kristian
AU - Berg, Rune W.
AU - Markos, Christos
N1 - Publisher Copyright: © 2023 Optica Publishing Group.
PY - 2023
Y1 - 2023
N2 - Variation of the brain temperature is strongly affected by blood flow, oxygen supply, and neural cell metabolism. Localized monitoring of the brain temperature is one of the most effective ways to correlate brain functions and diseases such as stroke, epilepsy, and mood disorders. While polymer optical fibers (POFs) are considered ideal candidates for temperature sensing in the brain, they have never been used so far in vivo. Here, we developed for the first, to the best of our knowledge, time an implantable probe based on a microstructured polymer optical fiber Bragg grating (FBG) sensor for intracranial brain temperature mapping. The temperature at different depths of the brain (starting from the cerebral cortex) and the correlation between the brain and body core temperature of a rat were recorded with a sensitivity of 33 pm/°C and accuracy <0.2°C. Our in vivo experimental results suggest that the proposed device can achieve real-time and high-resolution local temperature measurement in the brain, as well as being integrated with existing neural interfaces.
AB - Variation of the brain temperature is strongly affected by blood flow, oxygen supply, and neural cell metabolism. Localized monitoring of the brain temperature is one of the most effective ways to correlate brain functions and diseases such as stroke, epilepsy, and mood disorders. While polymer optical fibers (POFs) are considered ideal candidates for temperature sensing in the brain, they have never been used so far in vivo. Here, we developed for the first, to the best of our knowledge, time an implantable probe based on a microstructured polymer optical fiber Bragg grating (FBG) sensor for intracranial brain temperature mapping. The temperature at different depths of the brain (starting from the cerebral cortex) and the correlation between the brain and body core temperature of a rat were recorded with a sensitivity of 33 pm/°C and accuracy <0.2°C. Our in vivo experimental results suggest that the proposed device can achieve real-time and high-resolution local temperature measurement in the brain, as well as being integrated with existing neural interfaces.
U2 - 10.1364/OL.498031
DO - 10.1364/OL.498031
M3 - Journal article
C2 - 37581998
AN - SCOPUS:85168061933
VL - 48
SP - 4225
EP - 4228
JO - Optics Letters
JF - Optics Letters
SN - 0146-9592
IS - 16
ER -
ID: 367703441