Impaired Ability to Suppress Excitability of Antagonist Motoneurons at Onset of Dorsiflexion in Adults with Cerebral Palsy
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Impaired Ability to Suppress Excitability of Antagonist Motoneurons at Onset of Dorsiflexion in Adults with Cerebral Palsy. / Geertsen, Svend Sparre; Kirk, Henrik; Nielsen, Jens Bo.
In: Neural Plasticity, Vol. 2018, 1265143, 2018.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Impaired Ability to Suppress Excitability of Antagonist Motoneurons at Onset of Dorsiflexion in Adults with Cerebral Palsy
AU - Geertsen, Svend Sparre
AU - Kirk, Henrik
AU - Nielsen, Jens Bo
N1 - CURIS 2018 NEXS 348
PY - 2018
Y1 - 2018
N2 - We recently showed that impaired gait function in adults with cerebral palsy (CP) is associated with reduced rate of force development in ankle dorsiflexors. Here, we explore potential mechanisms. We investigated the suppression of antagonist excitability, calculated as the amount of soleus H-reflex depression at the onset of ankle dorsiflexion compared to rest, in 24 adults with CP (34.3 years, range 18–57; GMFCS 1.95, range 1–3) and 15 healthy, age-matched controls. Furthermore, the central common drive to dorsiflexor motoneurons during a static contraction in the two groups was examined by coherence analyses. The H-reflex was significantly reduced by 37% at the onset of dorsiflexion compared to rest in healthy adults (P < 0.001) but unchanged in adults with CP (P = 0.91). Also, the adults with CP had significantly less coherence. These findings suggest that the ability to suppress antagonist motoneuronal excitability at movement onset is impaired and that the central common drive during static contractions is reduced in adults with CP.
AB - We recently showed that impaired gait function in adults with cerebral palsy (CP) is associated with reduced rate of force development in ankle dorsiflexors. Here, we explore potential mechanisms. We investigated the suppression of antagonist excitability, calculated as the amount of soleus H-reflex depression at the onset of ankle dorsiflexion compared to rest, in 24 adults with CP (34.3 years, range 18–57; GMFCS 1.95, range 1–3) and 15 healthy, age-matched controls. Furthermore, the central common drive to dorsiflexor motoneurons during a static contraction in the two groups was examined by coherence analyses. The H-reflex was significantly reduced by 37% at the onset of dorsiflexion compared to rest in healthy adults (P < 0.001) but unchanged in adults with CP (P = 0.91). Also, the adults with CP had significantly less coherence. These findings suggest that the ability to suppress antagonist motoneuronal excitability at movement onset is impaired and that the central common drive during static contractions is reduced in adults with CP.
KW - Adolescent
KW - Adult
KW - Cerebral Palsy/diagnosis
KW - Electromyography/methods
KW - Female
KW - H-Reflex/physiology
KW - Humans
KW - Male
KW - Middle Aged
KW - Motor Neurons/physiology
KW - Muscle, Skeletal/physiopathology
KW - Range of Motion, Articular/physiology
KW - Reaction Time/physiology
KW - Young Adult
U2 - 10.1155/2018/1265143
DO - 10.1155/2018/1265143
M3 - Journal article
C2 - 30402086
VL - 2018
JO - Neural Plasticity
JF - Neural Plasticity
SN - 2090-5904
M1 - 1265143
ER -
ID: 203561248