Impact of the erythropoietin-derived peptide mimetic Epotris on the histopathological consequences of status epilepticus

Research output: Contribution to journal › Journal article › Research › peer-review

Standard

Impact of the erythropoietin-derived peptide mimetic Epotris on the histopathological consequences of status epilepticus. / Zellinger, Christina; Seeger, Natalie; Hadamitzky, Martin; Fischborn, Sarah; Russmann, Vera; Wendt, Hannes; Pankratova, Stanislava; Bock, Elisabeth; Berezin, Vladimir; Potschka, Heidrun.

In: Epilepsy Research, 06.07.2011.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Zellinger, C, Seeger, N, Hadamitzky, M, Fischborn, S, Russmann, V, Wendt, H, Pankratova, S, Bock, E, Berezin, V & Potschka, H 2011, 'Impact of the erythropoietin-derived peptide mimetic Epotris on the histopathological consequences of status epilepticus', Epilepsy Research. https://doi.org/10.1016/j.eplepsyres.2011.06.009

APA

Zellinger, C., Seeger, N., Hadamitzky, M., Fischborn, S., Russmann, V., Wendt, H., Pankratova, S., Bock, E., Berezin, V., & Potschka, H. (2011). Impact of the erythropoietin-derived peptide mimetic Epotris on the histopathological consequences of status epilepticus. Epilepsy Research. https://doi.org/10.1016/j.eplepsyres.2011.06.009

Vancouver

Zellinger C, Seeger N, Hadamitzky M, Fischborn S, Russmann V, Wendt H et al. Impact of the erythropoietin-derived peptide mimetic Epotris on the histopathological consequences of status epilepticus. Epilepsy Research. 2011 Jul 6. https://doi.org/10.1016/j.eplepsyres.2011.06.009

Author

Zellinger, Christina ; Seeger, Natalie ; Hadamitzky, Martin ; Fischborn, Sarah ; Russmann, Vera ; Wendt, Hannes ; Pankratova, Stanislava ; Bock, Elisabeth ; Berezin, Vladimir ; Potschka, Heidrun. / Impact of the erythropoietin-derived peptide mimetic Epotris on the histopathological consequences of status epilepticus. In: Epilepsy Research. 2011.

Bibtex

@article{9b192e2d466548de9038db7b50b547e8,
title = "Impact of the erythropoietin-derived peptide mimetic Epotris on the histopathological consequences of status epilepticus",
abstract = "The design of peptide mimetics offers interesting opportunities to selectively include beneficial and exclude undesirable effects of a parent molecule. Epotris represents a novel erythropoietin mimetic, which lacks an erythropoietic activity. The present study evaluates the potential of this peptide to interfere with the histopathological consequences of electrical-induced status epilepticus in rats. The peptide attenuated status epilepticus-associated expansion of the neuronal progenitor cell population in a significant manner. Moreover, Epotris affected the number of persistent basal dendrites exhibited by neuronal progenitor cells. In contrast, hippocampal cell loss remained unaffected by administration of this peptide mimetic. Status epilepticus resulted in obvious microglial activation in different brain regions involved in seizure generation and spread. Epotris diminished the microglial response caused by prolonged seizure activity in the thalamus but not in other brain regions. The study renders support that the Epotris' sequences from binding site 2 in helix C of Epo play a role in receptor interaction and cytokine function. In addition, the data demonstrate that Epotris can exert limited in vivo effects on the cellular consequences of prolonged seizure activity. When considering further testing it should be taken in mind that Epotris administration only attenuated selected cellular consequences of status epilepticus and did not completely prevent cellular alterations.",
author = "Christina Zellinger and Natalie Seeger and Martin Hadamitzky and Sarah Fischborn and Vera Russmann and Hannes Wendt and Stanislava Pankratova and Elisabeth Bock and Vladimir Berezin and Heidrun Potschka",
note = "Copyright {\textcopyright} 2011 Elsevier B.V. All rights reserved.",
year = "2011",
month = jul,
day = "6",
doi = "10.1016/j.eplepsyres.2011.06.009",
language = "English",
journal = "Journal of Epilepsy",
issn = "0920-1211",
publisher = "Elsevier",

}

RIS

TY - JOUR

T1 - Impact of the erythropoietin-derived peptide mimetic Epotris on the histopathological consequences of status epilepticus

AU - Zellinger, Christina

AU - Seeger, Natalie

AU - Hadamitzky, Martin

AU - Fischborn, Sarah

AU - Russmann, Vera

AU - Wendt, Hannes

AU - Pankratova, Stanislava

AU - Bock, Elisabeth

AU - Berezin, Vladimir

AU - Potschka, Heidrun

N1 - Copyright © 2011 Elsevier B.V. All rights reserved.

PY - 2011/7/6

Y1 - 2011/7/6

N2 - The design of peptide mimetics offers interesting opportunities to selectively include beneficial and exclude undesirable effects of a parent molecule. Epotris represents a novel erythropoietin mimetic, which lacks an erythropoietic activity. The present study evaluates the potential of this peptide to interfere with the histopathological consequences of electrical-induced status epilepticus in rats. The peptide attenuated status epilepticus-associated expansion of the neuronal progenitor cell population in a significant manner. Moreover, Epotris affected the number of persistent basal dendrites exhibited by neuronal progenitor cells. In contrast, hippocampal cell loss remained unaffected by administration of this peptide mimetic. Status epilepticus resulted in obvious microglial activation in different brain regions involved in seizure generation and spread. Epotris diminished the microglial response caused by prolonged seizure activity in the thalamus but not in other brain regions. The study renders support that the Epotris' sequences from binding site 2 in helix C of Epo play a role in receptor interaction and cytokine function. In addition, the data demonstrate that Epotris can exert limited in vivo effects on the cellular consequences of prolonged seizure activity. When considering further testing it should be taken in mind that Epotris administration only attenuated selected cellular consequences of status epilepticus and did not completely prevent cellular alterations.

AB - The design of peptide mimetics offers interesting opportunities to selectively include beneficial and exclude undesirable effects of a parent molecule. Epotris represents a novel erythropoietin mimetic, which lacks an erythropoietic activity. The present study evaluates the potential of this peptide to interfere with the histopathological consequences of electrical-induced status epilepticus in rats. The peptide attenuated status epilepticus-associated expansion of the neuronal progenitor cell population in a significant manner. Moreover, Epotris affected the number of persistent basal dendrites exhibited by neuronal progenitor cells. In contrast, hippocampal cell loss remained unaffected by administration of this peptide mimetic. Status epilepticus resulted in obvious microglial activation in different brain regions involved in seizure generation and spread. Epotris diminished the microglial response caused by prolonged seizure activity in the thalamus but not in other brain regions. The study renders support that the Epotris' sequences from binding site 2 in helix C of Epo play a role in receptor interaction and cytokine function. In addition, the data demonstrate that Epotris can exert limited in vivo effects on the cellular consequences of prolonged seizure activity. When considering further testing it should be taken in mind that Epotris administration only attenuated selected cellular consequences of status epilepticus and did not completely prevent cellular alterations.

U2 - 10.1016/j.eplepsyres.2011.06.009

DO - 10.1016/j.eplepsyres.2011.06.009

M3 - Journal article

C2 - 21741213

JO - Journal of Epilepsy

JF - Journal of Epilepsy

SN - 0920-1211

ER -

ID: 34239269