Immunohistochemical localisation and developmental aspects of epidermal growth factor in the rat
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Immunohistochemical localisation and developmental aspects of epidermal growth factor in the rat. / Raaberg, L.; Nexo, E.; Mikkelsen, J. Damsgaard; Poulsen, S. Seier.
In: Histochemistry, Vol. 89, No. 4, 01.07.1988, p. 351-356.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Immunohistochemical localisation and developmental aspects of epidermal growth factor in the rat
AU - Raaberg, L.
AU - Nexo, E.
AU - Mikkelsen, J. Damsgaard
AU - Poulsen, S. Seier
PY - 1988/7/1
Y1 - 1988/7/1
N2 - The tissue localisation and time of first appearance of Epidermal Growth Factor (EGF) in the developing rat were investigated by means of immunohistochemistry, radioimmunoassay and radioreceptor assay. In this study we were able to show, that EGF appears prenatally in the lung and the kidney from gestational day 19. Postnatally EGF was found also in the gastrointestinal tract, first in Brunner's glands of the duodenum (at birth), next in the Paneth cells (day 7), and finally in the submandibular glands (day 25). The immunohistochemical and radioreceptor results are consistent, whereas the radioimmunoassay detects EGF later and in smaller quantities, than does the radioreceptor assay. These differences will be discussed.
AB - The tissue localisation and time of first appearance of Epidermal Growth Factor (EGF) in the developing rat were investigated by means of immunohistochemistry, radioimmunoassay and radioreceptor assay. In this study we were able to show, that EGF appears prenatally in the lung and the kidney from gestational day 19. Postnatally EGF was found also in the gastrointestinal tract, first in Brunner's glands of the duodenum (at birth), next in the Paneth cells (day 7), and finally in the submandibular glands (day 25). The immunohistochemical and radioreceptor results are consistent, whereas the radioimmunoassay detects EGF later and in smaller quantities, than does the radioreceptor assay. These differences will be discussed.
UR - http://www.scopus.com/inward/record.url?scp=0023882463&partnerID=8YFLogxK
U2 - 10.1007/BF00500636
DO - 10.1007/BF00500636
M3 - Journal article
C2 - 3261722
AN - SCOPUS:0023882463
VL - 89
SP - 351
EP - 356
JO - Histochemistry
JF - Histochemistry
SN - 0301-5564
IS - 4
ER -
ID: 199324673