How plastic are human spinal cord motor circuitries?

Research output: Contribution to journal › Review › Research › peer-review

Standard

How plastic are human spinal cord motor circuitries? / Christiansen, Lasse; Lundbye-Jensen, Jesper; Perez, Monica A; Nielsen, Jens Bo.

In: Experimental Brain Research, Vol. 235, No. 11, 2017, p. 3243-3249.

Research output: Contribution to journal › Review › Research › peer-review

Harvard

Christiansen, L, Lundbye-Jensen, J, Perez, MA & Nielsen, JB 2017, 'How plastic are human spinal cord motor circuitries?', Experimental Brain Research, vol. 235, no. 11, pp. 3243-3249. https://doi.org/10.1007/s00221-017-5037-x

APA

Christiansen, L., Lundbye-Jensen, J., Perez, M. A., & Nielsen, J. B. (2017). How plastic are human spinal cord motor circuitries? Experimental Brain Research, 235(11), 3243-3249. https://doi.org/10.1007/s00221-017-5037-x

Vancouver

Christiansen L, Lundbye-Jensen J, Perez MA, Nielsen JB. How plastic are human spinal cord motor circuitries? Experimental Brain Research. 2017;235(11):3243-3249. https://doi.org/10.1007/s00221-017-5037-x

Author

Christiansen, Lasse ; Lundbye-Jensen, Jesper ; Perez, Monica A ; Nielsen, Jens Bo. / How plastic are human spinal cord motor circuitries?. In: Experimental Brain Research. 2017 ; Vol. 235, No. 11. pp. 3243-3249.

Bibtex

@article{fecea88e833642d58dd0c384555d565d,
title = "How plastic are human spinal cord motor circuitries?",
abstract = "Human and animal studies have documented that neural circuitries in the spinal cord show adaptive changes caused by altered supraspinal and/or afferent input to the spinal circuitry in relation to learning, immobilization, injury and neurorehabilitation. Reversible adaptations following, e.g. the acquisition or refinement of a motor skill rely heavily on the functional integration between supraspinal and sensory inputs to the spinal cord networks. Accordingly, what is frequently conceived as a change in the spinal circuitry may be a change in either descending or afferent input or in the relative integration of these, i.e. a change in the neuronal weighting. This is evident from findings documenting only task-specific functional changes after periods of altered inputs whereas resting responses remain unaffected. In fact, the proximity of the spinal circuitry to the outer world may demand a more rigid organization compared to the highly flexible cortical circuits. The understanding of all of this is important for the planning and execution of neurorehabilitation.",
keywords = "Humans, Motor control, Plasticity, Reflexes, Spinal cord",
author = "Lasse Christiansen and Jesper Lundbye-Jensen and Perez, {Monica A} and Nielsen, {Jens Bo}",
note = "CURIS 2017 NEXS 186",
year = "2017",
doi = "10.1007/s00221-017-5037-x",
language = "English",
volume = "235",
pages = "3243--3249",
journal = "Experimental Brain Research",
issn = "0014-4819",
publisher = "Springer",
number = "11",

}

RIS

TY - JOUR

T1 - How plastic are human spinal cord motor circuitries?

AU - Christiansen, Lasse

AU - Lundbye-Jensen, Jesper

AU - Perez, Monica A

AU - Nielsen, Jens Bo

N1 - CURIS 2017 NEXS 186

PY - 2017

Y1 - 2017

N2 - Human and animal studies have documented that neural circuitries in the spinal cord show adaptive changes caused by altered supraspinal and/or afferent input to the spinal circuitry in relation to learning, immobilization, injury and neurorehabilitation. Reversible adaptations following, e.g. the acquisition or refinement of a motor skill rely heavily on the functional integration between supraspinal and sensory inputs to the spinal cord networks. Accordingly, what is frequently conceived as a change in the spinal circuitry may be a change in either descending or afferent input or in the relative integration of these, i.e. a change in the neuronal weighting. This is evident from findings documenting only task-specific functional changes after periods of altered inputs whereas resting responses remain unaffected. In fact, the proximity of the spinal circuitry to the outer world may demand a more rigid organization compared to the highly flexible cortical circuits. The understanding of all of this is important for the planning and execution of neurorehabilitation.

AB - Human and animal studies have documented that neural circuitries in the spinal cord show adaptive changes caused by altered supraspinal and/or afferent input to the spinal circuitry in relation to learning, immobilization, injury and neurorehabilitation. Reversible adaptations following, e.g. the acquisition or refinement of a motor skill rely heavily on the functional integration between supraspinal and sensory inputs to the spinal cord networks. Accordingly, what is frequently conceived as a change in the spinal circuitry may be a change in either descending or afferent input or in the relative integration of these, i.e. a change in the neuronal weighting. This is evident from findings documenting only task-specific functional changes after periods of altered inputs whereas resting responses remain unaffected. In fact, the proximity of the spinal circuitry to the outer world may demand a more rigid organization compared to the highly flexible cortical circuits. The understanding of all of this is important for the planning and execution of neurorehabilitation.

KW - Humans

KW - Motor control

KW - Plasticity

KW - Reflexes

KW - Spinal cord

U2 - 10.1007/s00221-017-5037-x

DO - 10.1007/s00221-017-5037-x

M3 - Review

C2 - 28776155

VL - 235

SP - 3243

EP - 3249

JO - Experimental Brain Research

JF - Experimental Brain Research

SN - 0014-4819

IS - 11

ER -

ID: 181902554