High-intensity training in patients with lacunar stroke: A one-year follow-up
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High-intensity training in patients with lacunar stroke : A one-year follow-up. / Krawcyk, Rikke Steen; Vinther, Anders; Petersen, Nicolas Caesar; Faber, Jens; Iversen, Helle K.; Christensen, Thomas; Klausen, Tobias Wirenfeldt; Kruuse, Christina.
In: Journal of Stroke and Cerebrovascular Diseases, Vol. 32, No. 4, 106973, 2023.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - High-intensity training in patients with lacunar stroke
T2 - A one-year follow-up
AU - Krawcyk, Rikke Steen
AU - Vinther, Anders
AU - Petersen, Nicolas Caesar
AU - Faber, Jens
AU - Iversen, Helle K.
AU - Christensen, Thomas
AU - Klausen, Tobias Wirenfeldt
AU - Kruuse, Christina
N1 - Publisher Copyright: © 2022 The Authors
PY - 2023
Y1 - 2023
N2 - Objectives: Physical inactivity is a major risk factor for stroke. It is a challenge for patients to initiate and adhere to regular exercise post-stroke. Early initiation of home-based high-intensity interval training (HIIT) may engage patients in physical activity, improve cardiorespiratory fitness, and reduce risk of recurrent stroke. Materials and Methods: Post-intervention follow-up of patients with lacunar stroke, randomized to three-months HIIT including weekly motivational calls, or usual care. At follow-up (six- and 12-months post-stroke), we investigated changes in cardiorespiratory fitness, physical activity, fatigue, depression, mental well-being, stress, cognition, cardiovascular function, and recurrent stroke. Results: We included 71 patients of whom 59 patients (mean age: 63.9 ± 8.8 years) completed six- and 12-month follow-up. No change was detected in cardiorespiratory fitness between groups from baseline to 12-months follow-up. At six months, vigorous-intensity activity (median hours/week [interquartile range]) was maintained in the intervention group (baseline, 0[0;2]; post-intervention, 2[0;3]; six-month, 2[0;4]) and increased in the usual care group (baseline, 0[0;1]; post-intervention, 1[0;2]; six-month, 1[0;3]), with no difference between groups. Vigorous-intensity activity declined to baseline levels at 12-months in both groups. Secondary outcomes improved from baseline to 12-months with no significant differences between groups. Similar rate of recurrent stroke (n=3) occurred in each group with a three-month delay in the intervention group. Conclusions: Early initiated HIIT did not increase long-term cardiorespiratory fitness, but increased time spent doing vigorous-intensity activities post-stroke. Decline to baseline activity level at 12 months warrants identification of motivators to initiate and sustain physical activity post-stroke.
AB - Objectives: Physical inactivity is a major risk factor for stroke. It is a challenge for patients to initiate and adhere to regular exercise post-stroke. Early initiation of home-based high-intensity interval training (HIIT) may engage patients in physical activity, improve cardiorespiratory fitness, and reduce risk of recurrent stroke. Materials and Methods: Post-intervention follow-up of patients with lacunar stroke, randomized to three-months HIIT including weekly motivational calls, or usual care. At follow-up (six- and 12-months post-stroke), we investigated changes in cardiorespiratory fitness, physical activity, fatigue, depression, mental well-being, stress, cognition, cardiovascular function, and recurrent stroke. Results: We included 71 patients of whom 59 patients (mean age: 63.9 ± 8.8 years) completed six- and 12-month follow-up. No change was detected in cardiorespiratory fitness between groups from baseline to 12-months follow-up. At six months, vigorous-intensity activity (median hours/week [interquartile range]) was maintained in the intervention group (baseline, 0[0;2]; post-intervention, 2[0;3]; six-month, 2[0;4]) and increased in the usual care group (baseline, 0[0;1]; post-intervention, 1[0;2]; six-month, 1[0;3]), with no difference between groups. Vigorous-intensity activity declined to baseline levels at 12-months in both groups. Secondary outcomes improved from baseline to 12-months with no significant differences between groups. Similar rate of recurrent stroke (n=3) occurred in each group with a three-month delay in the intervention group. Conclusions: Early initiated HIIT did not increase long-term cardiorespiratory fitness, but increased time spent doing vigorous-intensity activities post-stroke. Decline to baseline activity level at 12 months warrants identification of motivators to initiate and sustain physical activity post-stroke.
KW - Cardiorespiratory fitness
KW - High-intensity-interval-training
KW - Lacunar stroke
KW - Long-term follow-up
KW - Physical activity
KW - Secondary stroke prevention
KW - Stroke recurrence
U2 - 10.1016/j.jstrokecerebrovasdis.2022.106973
DO - 10.1016/j.jstrokecerebrovasdis.2022.106973
M3 - Journal article
C2 - 36623990
AN - SCOPUS:85146017996
VL - 32
JO - Journal of Stroke & Cerebrovascular Diseases
JF - Journal of Stroke & Cerebrovascular Diseases
SN - 1052-3057
IS - 4
M1 - 106973
ER -
ID: 334264089