High- and low-affinity transport of D-glucose from blood to brain.

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Standard

High- and low-affinity transport of D-glucose from blood to brain. / Gjedde, A.

In: Journal of Neurochemistry, Vol. 36, No. 4, 1981, p. 1463-71.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Gjedde, A 1981, 'High- and low-affinity transport of D-glucose from blood to brain.', Journal of Neurochemistry, vol. 36, no. 4, pp. 1463-71.

APA

Gjedde, A. (1981). High- and low-affinity transport of D-glucose from blood to brain. Journal of Neurochemistry, 36(4), 1463-71.

Vancouver

Gjedde A. High- and low-affinity transport of D-glucose from blood to brain. Journal of Neurochemistry. 1981;36(4):1463-71.

Author

Gjedde, A. / High- and low-affinity transport of D-glucose from blood to brain. In: Journal of Neurochemistry. 1981 ; Vol. 36, No. 4. pp. 1463-71.

Bibtex

@article{00668f20b31511debc73000ea68e967b,
title = "High- and low-affinity transport of D-glucose from blood to brain.",
abstract = "Measurements of the unidirectional blood-brain glucose flux in rat were incompatible with a single set of kinetic constants for transendothelial transport. At least two transfer mechanisms were present: a high-affinity, low-capacity system, and a low-affinity, high-capacity system. The low-affinity system did not represent passive diffusion because it distinguished between D- and L-glucose. The Tmax and Km for the high-affinity system were 0.16 mmol 100 g-1 min-1 and 1 mM; for the low-affinity system, approximately 5 mmol 100 g-1 min-1 and approximately 1 M. With these values, physiological glucose concentrations were not sufficient to saturate the low-affinity system. In normoglycemia, therefore, three independent pathways of glucose transport from blood to brain appear to exist: a high-affinity facilitated diffusion pathway of apparent permeability 235 X 10(-7) cm s-1, a specific but nonsaturable diffusion pathway of permeability 85 x 10(-7) cm s-1, and a nonspecific passive diffusion pathway of permeability 2 x 10(-7) cm s-1.",
author = "A Gjedde",
year = "1981",
language = "English",
volume = "36",
pages = "1463--71",
journal = "Journal of Neurochemistry",
issn = "0022-3042",
publisher = "Wiley-Blackwell",
number = "4",

}

RIS

TY - JOUR

T1 - High- and low-affinity transport of D-glucose from blood to brain.

AU - Gjedde, A

PY - 1981

Y1 - 1981

N2 - Measurements of the unidirectional blood-brain glucose flux in rat were incompatible with a single set of kinetic constants for transendothelial transport. At least two transfer mechanisms were present: a high-affinity, low-capacity system, and a low-affinity, high-capacity system. The low-affinity system did not represent passive diffusion because it distinguished between D- and L-glucose. The Tmax and Km for the high-affinity system were 0.16 mmol 100 g-1 min-1 and 1 mM; for the low-affinity system, approximately 5 mmol 100 g-1 min-1 and approximately 1 M. With these values, physiological glucose concentrations were not sufficient to saturate the low-affinity system. In normoglycemia, therefore, three independent pathways of glucose transport from blood to brain appear to exist: a high-affinity facilitated diffusion pathway of apparent permeability 235 X 10(-7) cm s-1, a specific but nonsaturable diffusion pathway of permeability 85 x 10(-7) cm s-1, and a nonspecific passive diffusion pathway of permeability 2 x 10(-7) cm s-1.

AB - Measurements of the unidirectional blood-brain glucose flux in rat were incompatible with a single set of kinetic constants for transendothelial transport. At least two transfer mechanisms were present: a high-affinity, low-capacity system, and a low-affinity, high-capacity system. The low-affinity system did not represent passive diffusion because it distinguished between D- and L-glucose. The Tmax and Km for the high-affinity system were 0.16 mmol 100 g-1 min-1 and 1 mM; for the low-affinity system, approximately 5 mmol 100 g-1 min-1 and approximately 1 M. With these values, physiological glucose concentrations were not sufficient to saturate the low-affinity system. In normoglycemia, therefore, three independent pathways of glucose transport from blood to brain appear to exist: a high-affinity facilitated diffusion pathway of apparent permeability 235 X 10(-7) cm s-1, a specific but nonsaturable diffusion pathway of permeability 85 x 10(-7) cm s-1, and a nonspecific passive diffusion pathway of permeability 2 x 10(-7) cm s-1.

M3 - Journal article

C2 - 7264642

VL - 36

SP - 1463

EP - 1471

JO - Journal of Neurochemistry

JF - Journal of Neurochemistry

SN - 0022-3042

IS - 4

ER -

ID: 14943165